Immune abnormalities across psychiatric disorders: clinical relevance
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Summary: It is well established that the immune system can modulate brain functioning and influence behavioural processes. Awareness of communication between the immune and nervous systems has, over the years, progressively heightened interest in the relationship between psychiatric disorders and immune function. By reviewing findings from studies investigating inflammation in the periphery and in the central nervous systems, we summarise here the evidence linking inflammation to the development of depression, schizophrenia and bipolar disorder. We discuss how a pathophysiological role for inflammation has now been recognised across different psychiatric disorders, at least in a significant subpopulation of patients. Finally, we discuss a possible role for these findings in the development of future diagnostic classifications of psychiatric disorders as well as of new treatment strategies.
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Abnormal inflammatory responses have been observed in depression, bipolar disorder, and schizophrenia, classifying these disorders as chronic low-grade inflammatory diseases.
“Abnormal inflammatory responses have been observed in conditions such as depression, bipolar disorder, and schizophrenia, classifying these disorders as chronic low-grade inflammatory diseases [5].”
From Inflammatory ratios as predictors of length of hospitalization in psychiatric patients: A multicenter study (2025) · cites this paper as [5]
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References 51 · Cited by 17
- Authors
- Mondelli, V., Dazzan, P., & Pariante, C. M.
- Affiliations
- King's College London (GB)
- Venue
- BJPsych Advances
- Publisher
- Royal College of Psychiatrists
- Published
- 2015-05
- Volume
- 21
- Issue
- 3
- Pages
- 150-156
- ISSN
- 2056-4678 (ISSN-L)
- 2056-4686
- OpenAlex
- W2271500644
- Cited by
- 17
- References
- 51
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BJPsych Advances (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- South London and Maudsley NHS Foundation Trust
- National Institute for Health and Care Research
- King's College London
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- immune abnormalities, inflammation, mental illness, depression, schizophrenia, bipolar disorder, neuroinflammation, peripheral inflammation, psychiatric diagnosis, treatment options
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