Lithium in the Treatment of Aggression in Mentally Handicapped Patients: A Double-Blind Trial
Abstract
In a double-blind trial lasting 4 months in 42 mentally handicapped patients, the effect of lithium on aggression was assessed in comparison with placebo. In the lithium-treated group, 73% of patients showed a reduction in aggression during treatment. There were significant differences in mean weekly aggression scores and in the frequency of aggressive episodes between the lithium and placebo groups. Side-effects were noted in 36% of the lithium group (and 20% of the placebo group), but were mainly transitory. There were no episodes of toxicity, and no patients had to be withdrawn from the trial. Lithium appears to be worth a 2-month trial in such patients, where repeated aggression has not been relieved by more appropriate placement, occupation or company.
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There are two double-blind controlled trials showing beneficial effects of lithium compared with placebo in treating aggression in people with intellectual disability.
“There are two double-blind controlled trials show ing beneficial effects of lithium compared with placebo in treating aggression in people with intellectual disability.”
From Interventions for challenging behaviour in intellectual disability (2014) · cites this paper as Craft et al (1987)
The participants in the two studies were hospital inpatients.
“The participants in the two studies were hospital inpatients”
From Interventions for challenging behaviour in intellectual disability (2014) · cites this paper as Craft et al (1987)
In Craft et al (1987), a study of 42 patients randomised to lithium or placebo, 16 (73%) of the 22 receiving lithium showed a reduction in aggression over a 12-week period.
“Craft et al (1987), in a study of 42 patients randomised to lithium or placebo, found that 16 (73%) of the 22 receiving lithium showed a reduction in aggression over a 12-week period.”
From Interventions for challenging behaviour in intellectual disability (2014) · cites this paper as Craft et al (1987)
In Craft et al (1987), side-effects were reported in 8 (36%) of the patients on lithium compared with 4 (20%) on placebo.
“Side-effects were reported in 8 (36%) of the patients on lithium compared with 4 (20%) on placebo.”
From Interventions for challenging behaviour in intellectual disability (2014) · cites this paper as Craft et al (1987)
Most of the participants in the two lithium studies had not responded to other treatments.
“Most of the participants had not responded to other treatments.”
From Interventions for challenging behaviour in intellectual disability (2014) · cites this paper as Craft et al (1987)
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References 18 · Cited by 114
- Authors
- Craft, M., Ismail, I. A., Krishnamurti, D., Mathews, J., Regan, A., Seth, R. V., & North, P. M.
- Affiliations
- Leicester Frith Hospital (GB)
- University of Kent (GB)
- Corresponding author
- North, P. M.
- ORCID
- Ismail, I. A.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1987-05
- Volume
- 150
- Issue
- 5
- Pages
- 685-689
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2142199188
- Cited by
- 114
- References
- 18
- Citations by year
- 2024: 4 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 6
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- lithium, aggression, intellectual disability, mental disability, lithium side effects, lithium toxicity
- MeSH terms
- Adult, Aged, Aggression, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Lithium, Male, Intellectual Disability, Middle Aged, Time Factors, Lithium Carbonate
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