The DOI matches its Crossref record; 8 of the 9 references it cites were found in a registry or an index.
Plasma Levels of Fluphenazine Decanoate: Effects of site of injection, massage and muscle activity
Abstract
Depot neuroleptics are now commonly used for maintenance therapy of schizophrenia. Their physicochemical composition makes them ideal for such use because they are long-acting and show stable blood levels for prolonged periods. Their absorption from the site of injection may, however, be affected by local muscle factors. This paper describes three such factors in relation to fluphenazine decanoate: varying the site of injection; massage of the injection site; and effects of muscular exercise. Our results suggest that fluphenazine pharmacokinetics are not significantly affected by any of these factors.
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“Fluphenazine plasma concentrations are similar regardless of the injection site (buttock vs. thigh area), whether the injection site is massaged (vs. not), and whether the injection site undergoes muscular exercise (vs. not) [51].”
From Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview (2021) · cites this paper as [51]
Citations
Cites
Intramuscular or Intralipomatous Injections?
Cockshott, W. P., Thompson, G. T., Howlett, L. J., & Seeley, E. T. (1982) · New England Journal of Medicine · doi:10.1056/nejm198208053070607 · Cited by 146
Wode‐Helgodt, B., Borg, S., FYRÖ, B., & Sedvall, G. (1978) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1978.tb06929.x · Cited by 99
Plasma levels of lidocaine after intramuscular administration
Cohen, L. S., Rosenthal, J. E., Horner, D. W., Atkins, J. M., Matthews, O. A., & Sarnoff, S. J. (1972) · The American Journal of Cardiology · doi:10.1016/0002-9149(72)90442-0 · Cited by 62
Wiles, D., & Gelder, M. G. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb01045.x · Cited by 53
Self-citationAntiarrhythmic Effectiveness of Intramuscular Lidocaine: Influence of Different Injection Sites
Schwartz, M. L., Meyer, M. B., Covino, B. G., Narang, R. M., Sethi, V., SCHWARTZ, A. J., & KAMP, P. (1974) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1974.tb02293.x · Cited by 52
Radioimmunoassay for fluphenazine in human plasma.
Wiles, D., & Franklin, M. (1978) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1978.tb01636.x · Cited by 50
Self-citationHansen, T. I., & Kristensen, J. H. (1973) · PubMed · Cited by 43
Svendsen, O., Dencker, S. J., Fog, R., Gravem, A., & Kristjansen, P. (1980) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1980.tb01856.x · Cited by 9
Cited by
Correll, C. U., Kim, E., Sliwa, J. K., Hamm, W., Gopal, S., Mathews, M., Venkatasubramanian, R., & Saklad, S. R. (2021) · CNS Drugs · doi:10.1007/s40263-020-00779-5 · Cited by 205
Lipid based intramuscular long-acting injectables: Current state of the art
Wilkinson, J. M., Ajulo, D., Tamburrini, V., Gall, G. L., Kimpe, K., Holm, R., Belton, P., & Qi, S. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106253 · Cited by 57
Alcohol abuse in chronic schizophrenics: implications for management in the community
Soni, S. D., & Brownlee, M. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03143.x · Cited by 47
Self-citationFundamental understanding of drug absorption from a parenteral oil depot
Kalicharan, R. W., Schot, P., & Vromans, H. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.12.011 · Cited by 25
Spatial distribution of oil depots monitored in human muscle using MRI
Kalicharan, R. W., Baron, P., Oussoren, C., Bartels, L. W., & Vromans, H. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.03.064 · Cited by 21
“However, several other factors such as the injection site (Minto et al., 1997; Shaik et al., 2015; Soni et al., 1988), injection volume (Minto et al., 1997), the rate of bioconversion of the prodrug into the parent drug, the absorption and distribution of the oil vehicle and the extent of spreading…”
Metadata
- Authors
- Soni, S. D., Wiles, D., Schiff, A. A., & Bamrah, J. S.
- Affiliations
- Crichton Royal Hospital (GB)
- Greater Manchester Mental Health NHS Foundation Trust (GB)
- Corresponding author
- Soni, Som D.
- ORCID
- Bamrah, J. S.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 1988-09
- Volume
- 153
- Issue
- 3
- Pages
- 382-384
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2140436172
- Cited by
- 12
- References
- 9
- Citations by year
- 2022: 1 · 2021: 2 · 2016: 5 · 2015: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- fluphenazine decanoate, depot neuroleptics, long-acting antipsychotics, pharmacokinetics, plasma drug concentration, injection site, muscular exercise
- MeSH terms
- Adolescent, Adult, Chronic Disease, Delayed-Action Preparations, Physical Exertion, Fluphenazine, Humans, Injections, Intramuscular, Massage, Middle Aged, Schizophrenia
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