The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia
Open accessAbstract
Background: Both traditional and atypical antipsychotics have been hypothesised to be effective in schizophrenia through limbic and cortical D 2 dopamine receptor blockade. Aims: To investigate this hypothesis with the D 2/D 3-selective positron emission tomography (PET) probe [76 Br]-FLB457. Method: PETscans were performed on 6 controls and 18 patients with schizophreniatreated with haloperidol or with risperidone, clozapine, amisulpride or olanzapine. Results: The D 2 dopamine receptor blockade was high in the temporal cortex with both haloperidol and atypical antipsychotics. The atypicals, however, induced a significantly lower D 2 binding index than haloperidol in the thalamus and in the striatum. Conclusions: Results suggest that cortical D 2 dopamine receptors are a common target of traditional and atypical antipsychotics for therapeutic action. Higher in vivo binding to the D 2 receptors in the cortex than in the basal ganglia is suggested as an indicator of favourable profile for a putative antipsychotic compound.
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Coukell, A. J., Spencer, C. M., & Benfield, P. (1996) · CNS Drugs · doi:10.2165/00023210-199606030-00006 · Cited by 108
Cited by
Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988
Half a century of antipsychotics and still a central role for dopamine D2 receptors
Kapur, S., & Mamo, D. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.004 · Cited by 638
Miyamoto, S., Miyake, N., Jarskog, L. F., Fleischhacker, W. W., & Lieberman, J. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.47 · Cited by 573
Abi-Dargham, A., & Laruelle, M. (2005) · European Psychiatry · doi:10.1016/j.eurpsy.2004.11.003 · Cited by 179
KUROKI, T., NAGAO, N., & NAKAHARA, T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00910-2 · Cited by 146
Metadata
- Authors
- Xiberas, X., Martinot, J. L., Mallet, L., Artiges, E., Loc'h, C., Mazière, B., & Paillère-Martinot, M. L.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2001-12
- Volume
- 179
- Issue
- 6
- Pages
- 503-508
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2117669265
- Cited by
- 171
- References
- 1
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xiberas, X., Martinot, J. L., Mallet, L., Artiges, E., Loc'h, C., Mazière, B., & Paillère-Martinot, M. L. (2001). Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia. British Journal of Psychiatry. https://doi.org/10.1192/bjp.179.6.503
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
