Neural response to emotional prosody in schizophrenia and in bipolar affective disorder
Open accessAbstract
Background: Evidence suggests a reversal of the normal left-lateralised response to speech in schizophrenia. Aims: To test the brain's response to emotional prosody in schizophrenia and bipolar disorder. Method: BOLD contrast functional magnetic resonance imaging of subjects while they passively listened or attended to sentences that differed in emotional prosody. Results: Patients with schizophrenia exhibited normal right-lateralisation of the passive response to ‘pure’ emotional prosody and relative left-lateralisation of the response to unfiltered emotional prosody. When attending to emotional prosody, patients with schizophrenia activated the left insula more than healthy controls. When listening passively, patients with bipolar disorder demonstrated less activation of the bilateral superior temporal gyri in response to pure emotional prosody, and greater activation of the left superior temporal gyrus in response to unfiltered emotional prosody. In both passive experiments, the patient groups activated different lateral temporal lobe regions. Conclusions: Patients with schizophrenia and bipolar disorder may display some left-lateralisation of the normal right-lateralised temporal lobe response to emotional prosody.
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The lack of activation found in the right-sided prefrontal and temporal areas implicated in affective prosody recognition suggests a reduced neural capacity to process this type of emotional stimuli.
“The lack of activation found in the right-sided prefrontal and temporal areas implicated in affective prosody recognition (see the section discussing neural correlates of affective processing recognition) suggests a reduced neural capacity to process this type of emotional stimuli.”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [78]
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References 32 · Cited by 128
- Authors
- Mitchell, R. L. C., Elliott, R., Barry, M., Cruttenden, A., & Woodruff, P. W. R.
- Affiliations
- University of Reading (GB)
- University of Manchester (GB)
- University of Sheffield (GB)
- Corresponding author
- Mitchell, Rachel L. C.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2004-03
- Volume
- 184
- Issue
- 3
- Pages
- 223-230
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2093798197
- Cited by
- 128
- References
- 32
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 3 · 2014: 3 · 2013: 14 · 2012: 10
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Durham Research Online (Durham University) (acceptedVersion)
- CentAUR (University of Reading) (submittedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- emotional prosody, schizophrenia, bipolar disorder, hemispheric lateralization, insula, superior temporal gyrus, auditory processing, speech perception, passive listening, auditory attention
- MeSH terms
- Adult, Bipolar Disorder, Dominance, Cerebral, Emotions, Empathy, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Schizophrenia, Schizophrenic Language, Schizophrenic Psychology, Semantics, Speech Perception, Temporal Lobe
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