Antipsychotics and diabetes: review of non-prospective data
Open accessAbstract
Background: Much of the existing data regarding the relationship between antipsychotic medications and diabetes mellitus are non-prospective. Aims: To review critically non-prospective studies examining antipsychotic medications as risk factors for diabetes mellitus. Method: Database and manual searches. Results: Anecdotal reports indicate that conventional and atypical antipsychotics can cause diabetes mellitus. However, retrospective studies cannot reliably quantify this association, as they do not adequately control for confounding risk factors for diabetes, or for variation in detection and diagnosis of this illness. Most studies report a higher rate of diabetes in patients who use antipsychotic medication than in non-users, and in patients taking atypical v. conventional antipsychotics. Studies assessing the relative risks of diabetes between individual atypical antipsychotics are contradictory. Conclusions: Retrospective data are of limited value. Well-designed prospective studies, which account for potential confounders, are needed to investigate the true association between antipsychotic medications and diabetes.
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The adverse effects of antipsychotics include tardive dyskinesia, weight gain, and impaired glucose tolerance.
“The adverse effects of antipsychotics include tardive dyskinesia (Kane 2006), weight gain (Allison 1997), and impaired glucose tolerance (Haddad 2004).”
From Pharmacological interventions for those who have sexually offended or are at risk of offending (2015) · cites this paper as Haddad 2004
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Koro, C. E., Fedder, D. O., L'Italien, G. J., Weiss, S., Magder, L., Kreyenbuhl, J., Revicki, D., & Buchanan, R. (2002) · BMJ · doi:10.1136/bmj.325.7358.243 · Cited by 421 · see citing works
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- Braceland, F. J., Meduna, L. J.,Vaichulis, J. A. (1946) Delayed action of insulin in schizophrenia. Delayed action of insulin in schizophrenia. American American Journal of Psychiatry Journal of Psychiatry, , 102 102, 108^109. , 108^109.
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Pharmacological interventions for those who have sexually offended or are at risk of offending
Khan, O., Ferriter, M., Huband, N., Powney, M. J., Dennis, J. A., & Duggan, C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007989.pub2 · Cited by 144 · see citing works
- Authors
- Haddad, P. M.
- Corresponding author
- Haddad, Peter M.
- ORCID
- Haddad, Peter M.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2004-04
- Volume
- 184
- Issue
- S47
- Pages
- s80-s86
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2120802149
- Cited by
- 71
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- antipsychotic drugs, diabetes mellitus, atypical antipsychotics, typical antipsychotics, drug-induced diabetes, retrospective analysis, relative risk, prospective study
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Retrospective Studies, Risk Factors, Schizophrenia, Antipsychotic Agents, Prevalence
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