Cited by 185Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

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Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia

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Théberge, Jean, Williamson, Kate E., Aoyama, Naoko, Drost, Dick J., Manchanda, Rahul, Malla, Ashok K., Northcott, Sandra, Menon, Ravi S., Neufeld, Richard W. J., Rajakumar, Nagalingam, Pavlosky, William, Densmore, Maria, Schaefer, Betsy, Williamson, Peter C.·2007·British Journal of Psychiatry

DOI 10.1192/bjp.bp.106.033670

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Abstract

BACKGROUND: Progressive volumetric changes in the brains of people with schizophrenia have been attributed to a number of factors. AIMS: To determine whether glutamatergic changes in patients with schizophrenia correlated with grey-matter losses during the first years of illness. METHOD: Left anterior cingulate and thalamic glutamatergic metabolite levels and grey-matter volumes were examined in 16 patients with first-episode schizophrenia before and after 10 months and 30 months of antipsychotic treatment and in 16 healthy participants on two occasions 30 months apart. RESULTS: Higher than normal glutamine levels were found in the anterior cingulate and thalamus of never-treated patients. Thalamic levels of glutamine were significantly reduced after 30 months. Limited grey-matter reductions were seen in patients at 10 months followed by widespread grey-matter loss at 30 months. Parietal and temporal lobe grey-matter loss was correlated with thalamic glutamine loss. CONCLUSIONS: Elevated glutamine levels in never-treated patients followed by decreased thalamic glutamine and grey-matter loss in connected regions could indicate either neurodegeneration or a plastic response to reduced subcortical activity.

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Self-citation

Authors: Théberge, J., Williamson, K. E., Aoyama, N., Drost, D. J., Manchanda, R., Malla, A. K., Northcott, S., Menon, R. S., Neufeld, R. W. J., Rajakumar, N., Pavlosky, W., Densmore, M., Schaefer, B., & Williamson, P. C.
Affiliations: Western University (CA)
McGill University (CA)
St Joseph's Health Care (CA)
Corresponding author: Théberge, Jean
ORCID: Théberge, Jean
Manchanda, Rahul
Malla, Ashok K.
Menon, Ravi S.
Neufeld, Richard W. J.
Rajakumar, Nagalingam
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2007-10
Volume: 191
Issue: 4
Pages: 325-334
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.106.033670
OpenAlex: W2066003443
Cited by: 185
References: 42
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 10 · 2015: 13 · 2014: 16 · 2013: 12 · 2012: 18
FWCI: 5.64
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 3746 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (12078, MT-12078)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: first-episode schizophrenia, gray matter loss, glutamine, thalamus, anterior cingulate cortex, antipsychotic drugs, neurodegeneration, brain volumetric changes, longitudinal brain changes
MeSH terms: Adult, Female, Glutamine, Gyrus Cinguli, Humans, Functional Laterality, Longitudinal Studies, Magnetic Resonance Imaging, Male, Magnetic Resonance Spectroscopy, Schizophrenia, Thalamus, Time Factors, Case-Control Studies, Glutamic Acid

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Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia

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