Time course of regional brain activation associated with onset of auditory/verbal hallucinations
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The time course of brain activation prior to onset of auditory/verbal hallucinations was characterised using functional magnetic resonance imaging in six dextral patients with schizophrenia. Composite maps of pre-hallucination periods revealed activation in the left anterior insula and in the right middle temporal gyrus, partially replicating two previous case reports, as well as deactivation in the anterior cingulate and parahippocampal gyri. These findings may reflect brain events that trigger or increase vulnerability to auditory/verbal hallucinations.
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In a prior fMRI study, sites in left posterior BA22 and right BA21/22 activated concurrent with AVH events in a non-overlapping patient group.
“A bilateral Wernicke’s seed region comprised of sites in left posterior BA22 and a right homologous site in BA21/22 (Figure 1A) was delineated based on an earlier fMRI study showing activation in these sites concurrent with AVH events in a non-overlapping patient group (21).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [21]
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References 11 · Cited by 96
- Authors
- Hoffman, R. E., Anderson, A. W., Varanko, M., Gore, J. C., & Hampson, M.
- Affiliations
- Yale University (US)
- Vanderbilt University (US)
- Corresponding author
- Hoffman, Ralph E.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2008-11
- Volume
- 193
- Issue
- 5
- Pages
- 424-425
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC2801815
- OpenAlex
- W2134294863
- Cited by
- 96
- References
- 11
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 18
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dana Foundation
- Deutsches Krebsforschungszentrum
- University of Cambridge
- National Institutes of Health
- National Institute of Mental Health (R01MH067073)
- National Center for Research Resources (M01RR000125, RR00125)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- auditory verbal hallucinations, schizophrenia, anterior cingulate cortex, parahippocampal gyrus, brain deactivation
- MeSH terms
- Auditory Cortex, Brain, Gyrus Cinguli, Hallucinations, Humans, Schizophrenic Psychology, Time Factors, Parahippocampal Gyrus
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