Mood changes after delivery: role of the serotonin transporter gene
Open accessAbstract
Background: Polymorphic variations in the serotonin transporter gene (5-HTT) moderate the depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction in brain tryptophan availability, thus polymorphic variations in 5-HTT may play a similar role in the post-partum period. Aims: To study the role of 5-HTT polymorphic variations in mood changes after delivery. Method: One thousand, eight hundred and four depression-free Spanish women were studied post-partum. We evaluated depressive symptoms at 2–3 days, 8 weeks and 32 weeks post-partum. We used diagnostic interview to confirm major depression for all probable cases. Based on two polymorphisms of 5-HTT(5-HTTLPR and STin2 VNTR), three genotype combinations were created to reflect different levels of 5-HTT expression. Results: One hundred and seventy-three women (12.7%) experienced major depression during the 32-week post-partum period. Depressive symptoms were associated with the high-expression 5-HTT genotypes in a dose–response fashion at 8 weeks post-partum, but not at 32 weeks. Conclusions: High-expression 5-HTT genotypes may render women more vulnerable to depressive symptoms after childbirth.
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Post-birth decompensation in women with bipolar disorder is caused by genetic factors and by massive gonadal steroid withdrawal after birth in women who are neurobiologically sensitive to hormonal change.
“The causes of post-birth decompensation in women with bipolar disorder include genetic factors [31–33] and massive gonadal steroid withdrawal after birth in women who are neurobiologically sensitive to hormonal change [34].”
From Perinatal mental illness: Definition, description and aetiology (2014) · cites this paper as [33]
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References 49 · Cited by 109
- Authors
- Sanjuan, J., Martin-Santos, R., Garcia-Esteve, L., Carot, J. M., Guillamat, R., Gutierrez-Zotes, A., Gornemann, I., Canellas, F., Baca-Garcia, E., Jover, M., Navines, R., Valles, V., Vilella, E., de Diego, Y., Castro, J. A., Ivorra, J. L., Gelabert, E., Guitart, M., Labad, A., Mayoral, F., Roca, M., Gratacos, M., Costas, J., van Os, J., & de Frutos, R.
- Affiliations
- Corporació Sanitària Parc Taulí (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Institut Pere Mata (ES)
- Municipal Institute for Medical Research (ES)
- Hospital Universitario Son Dureta (ES)
- Servicio Gallego de Salud (ES)
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2008-11
- Volume
- 193
- Issue
- 5
- Pages
- 383-388
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2100119957
- Cited by
- 109
- References
- 49
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 2 · 2019: 10 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 13 · 2014: 10 · 2013: 10 · 2012: 10
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- postpartum depression, serotonin transporter gene, 5-HTT polymorphism, 5-HTTLPR, tryptophan depletion, dose-response relationship, major depressive disorder
- MeSH terms
- Female, Follow-Up Studies, Humans, Polymorphism, Genetic, Pregnancy, Prospective Studies, Risk Factors, Spain, Tryptophan, Gene Expression, Depression, Postpartum, Serotonin Plasma Membrane Transport Proteins
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