Association of cannabis use with prodromal symptoms of psychosis in adolescence
Open accessAbstract
Summary: Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.6% of the total sample) were more likely to present three or more prodromal symptoms even after controlling for confounders including previous behavioural symptoms (OR=2.23; 95% CI 1.70-2.94). A dose-response effect was seen. We conclude that cannabis use is associated with prodromal symptoms of psychosis in adolescence.
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Evidence from most case-control and cross-sectional studies supports an association between cannabis use and psychotic symptoms.
“Evidence from most case-control and cross-sectional studies support an association between cannabis use and schizophrenia (4-6) and psychotic symptoms (7)(8)(9).”
From Association Between Cannabis and Psychosis: Epidemiologic Evidence (2016) · cites this paper as [9]
The Discussion (page not provided) reports an association between cannabis use and prodromal symptoms of psychosis. But this paper describes its own study as a prospective birth-cohort study; our copy does not establish that most case-control and cross-sectional studies support the association. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThere is some evidence that residual confounding could still be present in some studies of cannabis and psychosis, as studies that adjusted for more confounders showed greater attenuation of unadjusted estimates than those that adjusted for fewer, with attenuation of 60-80% of the unadjusted estimate in the 3 studies that adjusted most comprehensively for confounding.
“There is some evidence that residual confounding could still be present in some of studies conducted to date, as studies of cannabis and psychosis that adjusted for more confounders showed greater attenuation of unadjusted estimates than those that adjusted for fewer, with attenuation of 60-80% of the unadjusted estimate in the 3 studies that adjusted most comprehensively for confounding (9).”
From Association Between Cannabis and Psychosis: Epidemiologic Evidence (2016) · cites this paper as [9]
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References 11 · Cited by 85
- Authors
- Miettunen, J., Törmänen, S., Murray, G. K., Jones, P. B., Mäki, P., Ebeling, H., Moilanen, I., Taanila, A., Heinimaa, M., Joukamaa, M., & Veijola, J.
- Affiliations
- Research Council of Finland (FI)
- Oulu University Hospital (FI)
- University of Cambridge (GB)
- University of Turku (FI)
- Tampere University Hospital (FI)
- Corresponding author
- Miettunen, Jouko
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2008-06
- Volume
- 192
- Issue
- 6
- Pages
- 470-471
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2160205326
- Cited by
- 85
- References
- 11
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland
- Signe ja Ane Gyllenbergin Säätiö
- Oulun Yliopisto
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- cannabis use, psychosis, prodromal symptoms, adolescents, psychosis risk, dose-response relationship, behavioural symptoms
- MeSH terms
- Adolescent, Child, Disease Susceptibility, Female, Humans, Male, Marijuana Smoking, Psychotic Disorders, Risk Factors, Cohort Studies, Confounding Factors, Epidemiologic
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