The DOI matches its Crossref record; 12 of the 13 references it cites were found in a registry or an index.
Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
Open accessAbstract
Cannabis contains various cannabinoids, two of which have almost opposing actions: Delta9-tetrahydrocannabinol (Delta9-THC) is psychotomimetic, whereas cannabidiol (CBD) has antipsychotic effects. Hair samples were analysed to examine levels of Delta9-THC and CBD in 140 individuals. Three clear groups emerged: ;THC only', ;THC+CBD' and those with no cannabinoid in hair. The THC only group showed higher levels of positive schizophrenia-like symptoms compared with the no cannabinoid and THC+CBD groups, and higher levels of delusions compared with the no cannabinoid group. This provides evidence of the divergent properties of cannabinoids and has important implications for research into the link between cannabis use and psychosis.
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“A number of studies indicate that cannabis strains containing higher THC:CBD ratios may result in greater risk of psychotic outcomes, and that CBD might have anti-psychotic properties (27)(28)(29)47).”
From Association Between Cannabis and Psychosis: Epidemiologic Evidence (2016) · cites this paper as [27]
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Cites
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Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
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Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo, E. B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01238.x · Cited by 1,535
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Cannabidiol as a Potential Treatment for Anxiety Disorders
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Metadata
- Authors
- Morgan, C. J. A., & Curran, H. V.
- Affiliations
- University College London (GB)
- Corresponding author
- Morgan, Celia J. A.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2008-04
- Volume
- 192
- Issue
- 4
- Pages
- 306-307
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2151439032
- Cited by
- 300
- References
- 13
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 26 · 2019: 17 · 2018: 19 · 2017: 20 · 2016: 22 · 2015: 25 · 2014: 18 · 2013: 23 · 2012: 18
- FWCI
- 14.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Economic and Social Research Council (RES-000-23-0945, RES-000-)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- cannabidiol, delta-9-tetrahydrocannabinol, cannabis use, schizophrenia-like symptoms, psychosis, delusions, hair analysis, cannabinoids, antipsychotic effects, psychotomimetic effects
- MeSH terms
- Adult, Analysis of Variance, Cannabidiol, Marijuana Abuse, Delusions, Female, Hair, Humans, Male, Predictive Value of Tests, Psychoses, Substance-Induced, Dronabinol
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