Quality of life of people with schizophrenia, bipolar disorder and other psychotic disorders
Open accessAbstract
BACKGROUND: Health utility and quality of life (QoL) are increasingly important outcome measures in healthcare and health economics. AIMS: To compare the loss of subjective QoL and utility-based health-related quality of life (HRQoL) associated with psychotic disorders. METHOD: A representative sample of 8028 Finns was screened for psychotic disorders and bipolar I disorder. Lifetime psychotic disorders were diagnosed using the Structured Clinical Interview for DSM-IV and/or case records. Health-related quality of life was measured with EQ-5D and 15D, and QoL was measured with a 10-point scale. RESULTS: Schizoaffective disorder was associated with the largest losses of QoL and HRQoL, with bipolar I disorder associated with similar or smaller losses than schizophrenia. Current depressive symptoms explained most of the losses. CONCLUSIONS: Depressive symptoms are the strongest predictors of poor QoL/HRQoL in psychotic disorders. Subjective loss of QoL associated with psychotic disorders may be smaller than objective loss of functioning suggests. The EQ-5D is problematic as an outcome measure in psychotic disorders.
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Depression contributes to poorer quality of life amongst individuals with psychosis and schizophrenia.
“Depression contributes to poorer quality of life amongst individuals with psychosis and schizophrenia (Saarni et al., 2010).”
From A parallel group randomised open blinded evaluation of A cceptance and Commitment Therapy for d epression a fter p sychosis: Pilot t rial outcomes (ADAPT) (2017) · cites this paper as Saarni et al., 2010
Depression is a major contributor to loss of quality of life in schizophrenia and other psychotic disorders.
“Depression is a major contributor to loss of quality of life in schizophrenia and other psychotic disorders (Saarni et al., 2010)”
From A parallel group randomised open blinded evaluation of A cceptance and Commitment Therapy for d epression a fter p sychosis: Pilot t rial outcomes (ADAPT) (2017) · cites this paper as Saarni et al., 2010
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References 50 · Cited by 251
Research works printed but not linked: 1
- First MB, Anthony JC, Tepper S, Dryman A. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-patient Edition (SCID-I/NP). Biometrics Research, New York State Psychiatric Institute, 1997.
- Authors
- Saarni, S. I., Viertiö, S., Perälä, J., Koskinen, S., Lönnqvist, J., & Suvisaari, J.
- Affiliations
- University of Helsinki (FI)
- Finnish Institute for Health and Welfare (FI)
- Corresponding author
- Saarni, Samuli I.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2010-11
- Volume
- 197
- Issue
- 5
- Pages
- 386-394
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2145372395
- Cited by
- 251
- References
- 50
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 13 · 2023: 16 · 2022: 15 · 2021: 24 · 2020: 23 · 2019: 10 · 2018: 13 · 2017: 20 · 2016: 22 · 2015: 17 · 2014: 12 · 2013: 22 · 2012: 15
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- quality of life, health-related quality of life, psychosis, schizophrenia, bipolar I disorder, schizoaffective disorder, depressive symptoms, EQ-5D, 15D, health utility, outcome measures
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Bipolar Disorder, Depression, Epidemiologic Methods, Female, Finland, Health Status, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychotic Disorders, Quality of Life, Review Literature as Topic, Schizophrenia, Schizophrenic Psychology, Self-Assessment, Socioeconomic Factors, Outcome Assessment, Health Care, Cost of Illness
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