Prescription of antipsychotics in people with dementia
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Summary Gerhard et al clarify our understanding of mortality associated with antipsychotic use in people with dementia, by demonstrating a clear dose relationship and highlighting key questions regarding the relative mortality risk of different atypical antipsychotics. The study also suggests that antipsychotics may confer risks of increased mortality in older people without dementia.
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Antipsychotics for behavioral and psychological symptoms of dementia are associated with substantial side-effects and short-term and long-term risks for morbidity and mortality.
“in some cases (eg, antipsychotics), is associated with substantial side-effects and short-term and long-term risks for morbidity and mortality.55”
From The Alzheimer’s Disease Clinical Spectrum (2019) · cites this paper as [55]
Treatment of behavioral and psychological symptoms of dementia using pharmacology alone has low treatment benefit effect sizes (Cohen's d 0.2).
“Treatment of BPSD using pharmacology alone has low treatment benefit effect sizes (Cohen's d 0.2)”
From The Alzheimer’s Disease Clinical Spectrum (2019) · cites this paper as [55]
Antipsychotics carry a US Food and Drug Administration black-box warning in dementia.
“Antipsychotics carry a US Food and Drug Administration (FDA) black-box warning in dementia; they must be used with extreme caution, ongoing monitoring, and only when strict conditions are met.55,56”
From The Alzheimer’s Disease Clinical Spectrum (2019) · cites this paper as [55]
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References 7 · Cited by 27
- Authors
- Ballard, C., Corbett, A., & Howard, R.
- Affiliations
- King's College London (GB)
- Corresponding author
- Ballard, Clive
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2014-07
- Volume
- 205
- Issue
- 1
- Pages
- 4-5
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W1990031205
- Cited by
- 27
- References
- 7
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2022: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- South London and Maudsley NHS Foundation Trust
- National Institute for Health and Care Research
- King's College London
- Menzies Centre for Australian Studies, King's College London, University of London
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- antipsychotic drugs, dementia, mortality risk, dose-response relationship, atypical antipsychotics, older adults, drug prescribing
- MeSH terms
- Female, Humans, Male, Psychotic Disorders, Antipsychotic Agents
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