Disorder, not just state of risk: Meta-analysis of functioning and quality of life in people at high risk of psychosis
Open accessAbstract
Background: The nosology of the psychosis high-risk state is controversial. Traditionally conceived as an ‘at risk’ state for the development of psychotic disorders, it is also conceptualised as a clinical syndrome associated with functional impairment. Aims: To investigate meta-analytically the functional status of patients at high clinical risk for psychosis and its association with longitudinal outcomes. Method: Three meta-analyses compared level of functioning ( n = 3012) and quality of life (QoL) ( n = 945) between a high-risk group, a healthy control group and group with psychosis, and baseline functioning in people in the high-risk group who did or did not have a transition to psychosis at follow-up ( n = 654). Results: People at high risk had a large impairment in functioning ( P <0.001) and worse QoL ( P = 0.001) than the healthy control group, but only small to moderately better functioning ( P = 0.012) and similar QoL ( P = 0.958) compared with the psychosis group. Among the high-risk group, those who did not develop psychosis reported better functioning ( P = 0.001) than those who did. Conclusions: Our results indicate that the high-risk state is characterised by consistent and large impairments of functioning and reduction in QoL similar to those in other coded psychiatric disorders.
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CHR-P individuals have functional impairments.
“functional impairments of CHR-P individuals 77”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [77]
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References 90 · Cited by 272
Research works printed but not linked: 4
- Ruhrmann S, Paruch J, Bechdolf A, Pukrop R, Wagner M, Berning J, et al. Reduced subjective quality of life in persons at risk for psychosis. Acta Psychiatr Scand 2008; 117: 357-68.
- Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-12.
- Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E, et al. Prediction of psychosis in youth at high clinical risk. Arch Gen Psychiatry 2008; 65: 28-37.
- Serrani D. Neurocognitive assessment of ultra high risk of psychosis states using the MATRICS battery (Measurement and Treatment Research to Improve Cognition in Schizophrenia). Rev Psiquiatr Clı ´n 2011; 38: 130-4.
- Authors
- Fusar-Poli, P., Rocchetti, M., Sardella, A., Avila, A., Brandizzi, M., Caverzasi, E., Politi, P., Ruhrmann, S., & McGuire, P.
- Affiliations
- University of Cologne (DE)
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2015-09
- Volume
- 207
- Issue
- 3
- Pages
- 198-206
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2202104541
- Cited by
- 272
- References
- 90
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 19 · 2023: 15 · 2022: 24 · 2021: 25 · 2020: 47 · 2019: 44 · 2018: 30 · 2017: 17 · 2016: 17 · 2015: 4
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- King's College London
- Sapienza Università di Roma
- Università degli Studi di Pavia
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- functional disability, quality of life, transition to psychosis, longitudinal outcomes, functional status
- MeSH terms
- Behavior, Female, Humans, Male, Psychotic Disorders, Quality of Life, Risk Factors, Case-Control Studies, Young Adult
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