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A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms
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Multiple genome-wide association studies did not find an association between Lp(a) levels and common variants at the LDLR locus.
“Multiple genome-wide association studies (GWAS) did not find an association between Lp(a) levels and common variants at the LDLR locus10,46,47, but a recent GWAS of 371,212 individuals in the UK Biobank did48.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [47]
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Cites
A method and server for predicting damaging missense mutations.
Adzhubei, I. A., Schmidt, S., Peshkin, L., Ramensky, V. E., Gerasimova, A., Bork, P., Kondrashov, A. S., & Sunyaev, S. R. (2010) · Nature Methods · doi:10.1038/nmeth0410-248 · Cited by 13,194
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
The GTEx Consortium, Ardlie, K. G., Deluca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., Maller, J. B., Tukiainen, T., et al. (2015) · Science · doi:10.1126/science.1262110 · Cited by 5,062
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
the CARDIoGRAMplusC4D Consortium (2015) · Nature Genetics · doi:10.1038/ng.3396 · Cited by 2,447
Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
Kamstrup, P. R. (2009) · JAMA · doi:10.1001/jama.2009.801 · Cited by 1,357 · cited 1×
“This is in line with several previous studies, which were performed primarily on the highly cited variants, rs10455872, rs3798220, and rs41272114 (10, 60, 61).”
ResultViney, N. J., van Capelleveen, J. C., Geary, R. S., Xia, S., Tami, J. A., Yu, R. Z., Marcovina, S. M., Hughes, S. G., Graham, M. J., Crooke, R. M., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31009-1 · Cited by 754 · cited 1×
“This is even more important in the light of emerging therapies, such as PCSK9-inhibitors or specific oligonucleotide therapies, that are able to lower Lp(a) levels by up to 30% and 90%, respectively (62, 63).”
BackgroundHan, B., & Eskin, E. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.04.014 · Cited by 680
Lipoprotein(a): resurrected by genetics
Kronenberg, F., & Utermann, G. (2013) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02592.x · Cited by 521
Self-citationA genome-wide association study identifies protein quantitative trait loci (pQTLs)
Melzer, D., Perry, J. R. B., Hernandez, D., Corsi, A.-M., Stevens, K., Rafferty, I., Lauretani, F., Murray, A., Gibbs, J. R., Paolisso, G., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000072 · Cited by 480
Apolipoprotein E isoforms and lipoprotein metabolism
Phillips, M. C. (2014) · IUBMB Life · doi:10.1002/iub.1314 · Cited by 328
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Metadata
- Authors
- Mack, S., Coassin, S., Rueedi, R., Yousri, N. A., Seppälä, I., Gieger, C., Schönherr, S., Forer, L., Erhart, G., Marques-Vidal, P., Ried, J. S., Waeber, G., Bergmann, S., Dähnhardt, D., Stöckl, A., Raitakari, O. T., Kähönen, M., Peters, A., Meitinger, T., Strauch, K., Kedenko, L., Paulweber, B., Lehtimäki, T., Hunt, S. C., Vollenweider, P., Lamina, C., & Kronenberg, F.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 58
- Issue
- 9
- Pages
- 1834-1844
- ISSN
- 0022-2275
- PMC
- PMC5580897
- Cited by
- 186
- References
- 9
- Language
- en
- Licence
- Funders
- Austrian Science Fund (P 26660-B13)
- Qatar Foundation
- National Heart, Lung, and Blood Institute (U01 HL67893, U01 HL67894, U01 HL67895, U01 HL67896, U01 HL67897, U01 HL67898, U01 HL67899, U01 HL67900, U01 HL67901, U01 HL67902)
- Swiss National Science Foundation (33CSCO-122661, 33CS30-139468, 33CS30-148401)
- Federal Ministry of Education and Research
- Academy of Finland (286284, 134309, 126925, 121584, 124282, 129378, 117787, 41071)
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Cultural Foundation
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- Yrjö Jahnsson Foundation
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