The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Cyclooxygenases: structural and functional insights
Open accessAbstract
Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever, inflammation, and tumorigenesis. The ubiquitous constitutive expression of COX-1 and inducible expression of COX-2 have led to the widely held belief that COX-1 produces homeostatic PGs, while PGs produced by COX-2 are primarily pathophysiological. However, recent discoveries call this paradigm into question and reveal as yet underappreciated functions for both enzymes. This review focuses on some of these new insights.
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Cites
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Cited by
In situ click chemistry generation of cyclooxygenase-2 inhibitors
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Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective
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Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
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Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
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Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis
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Metadata
- Authors
- Rouzer, C. A., & Marnett, L. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S29-S34
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2127161627
- Cited by
- 688
- References
- 42
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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