Oxidative Stress to Dopaminergic Neurons as Models of Parkinson's Disease
Abstract
A bstract: The effects of exogenous toxins (MPP+, rotenone) and potentially neurotoxic properties of levodopa (L‐DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP+‐toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q 10 (CoQ 10) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP+ is demonstrated.
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In vitro PD models confirmed protective effect of CoQ10, showing significantly reduced loss of dopaminergic cells.
“In vitro PD models confirmed the protective effect of CoQ10, showing significantly reduced loss of dopaminergic cells (Gille et al. 2004).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Gille et al. 2004
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References 18 · Cited by 53
- Authors
- GILLE, G., HUNG, S., REICHMANN, H., & RAUSCH, W.
- Affiliations
- University of Veterinary Medicine Vienna (AT)
- Technische Universität Dresden (DE)
- Corresponding author
- RAUSCH, W‐D
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2004-06
- Volume
- 1018
- Issue
- 1
- Pages
- 533-540
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2085425039
- Cited by
- 53
- References
- 18
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2017: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, dopaminergic neurons, oxidative stress, MPP+, rotenone, dopamine agonists, coenzyme Q10, tyrosine hydroxylase, respiratory chain complexes, hexokinase, neuroprotection
- MeSH terms
- Animals, Coenzymes, Disease Models, Animal, Dopamine, Mice, Inbred C57BL, Neurons, Neurotoxins, Parkinson Disease, Tyrosine 3-Monooxygenase, Ubiquinone, Oxidative Stress, Dopamine Agonists, Mice
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