Significance of Proximal Tubular Metabolism of Advanced Glycation End Products in Kidney Diseases

A bstract : Advanced glycation end products (AGEs) are formed by the nonenzymatic Maillard reaction between sugars and proteins. Low‐molecular weight AGEs are filtered by renal glomeruli and then reabsorbed and metabolized by proximal tubule cells (PTCs). High‐molecular weight AGEs are also deliv…