The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Bisphosphonates: An Update on Mechanisms of Action and How These Relate to Clinical Efficacy
Abstract
Abstract: The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. There is considerable new knowledge about how BPs work. Their classical pharmacological effects appear to result from two key properties: their affinity for bone mineral and their inhibitory effects on osteoclasts. Mineral binding affinities differ among the clinically used BPs and may influence their differential distribution within bone, their biological potency, and their duration of action. The inhibitory effects of the nitrogen‐containing BPs (including alendronate, risedronate, ibandronate, and zoledronate) on osteoclasts appear to result from their inhibition of farnesyl pyrophosphate synthase (FPPS), a key branch‐point enzyme in the mevalonate pathway. FPPS generates isoprenoid lipids used for the posttranslational modification of small GTP‐binding proteins essential for osteoclast function. Effects on other cellular pathways, such as preventing apoptosis in osteocytes, are emerging as other potentially important mechanisms of action. As a class, BPs share several common properties. However, as with other classes of drugs, there are obvious chemical, biochemical, and pharmacological differences among the various individual BPs. Each BP has a unique profile that may help to explain potential important clinical differences among the BPs, in terms of speed of onset of fracture reduction, antifracture efficacy at different skeletal sites, and the degree and duration of suppression of bone turnover. As we approach the 40th anniversary of the discovery of their biological effects, there remain further opportunities for using their properties for medical purposes.
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Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis
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Effect of Risedronate on the Risk of Hip Fracture in Elderly Women
McClung, M. R., Geusens, P., Miller, P. D., Zippel, H., Bensen, W. G., Roux, C., Adami, S., Fogelman, I., Diamond, T., Eastell, R., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440503 · Cited by 1,918
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Self-citationSeverely Suppressed Bone Turnover: A Potential Complication of Alendronate Therapy
Odvina, C. V., Zerwekh, J. E., Rao, D. S., Maalouf, N., Gottschalk, F. A., & Pak, C. Y. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0952 · Cited by 1,432
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Ten Years' Experience with Alendronate for Osteoporosis in Postmenopausal Women
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Cited by
Bauer, K. N., Tee, H. T., Velencoso, M. M., & Wurm, F. R. (2017) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.05.004 · Cited by 189
Sieber, P., Lardelli, P., Kraenzlin, C. A., Kraenzlin, M. E., & Meier, C. (2013) · Clinical Drug Investigation · doi:10.1007/s40261-012-0041-1 · Cited by 49
Unexpected Bone Formation Produced by RANKL Blockade
Portal-Núñez, S., Mediero, A., Esbrit, P., Sánchez-Pernaute, O., Largo, R., & Herrero-Beaumont, G. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.06.003 · Cited by 32
Ishii, T., Shimazu, Y., Nishiyama, I., Kikuta, J., & Ishii, M. (2011) · Molecules and Cells · doi:10.1007/s10059-011-1010-x · Cited by 32
Kast, R. E. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47030153 · Cited by 5
Metadata
- Authors
- RUSSELL, R. G. G., XIA, Z., DUNFORD, J. E., OPPERMANN, U., KWAASI, A., HULLEY, P. A., KAVANAGH, K. L., TRIFFITT, J. T., LUNDY, M. W., PHIPPS, R. J., BARNETT, B. L., COXON, F. P., ROGERS, M. J., WATTS, N. B., & EBETINO, F. H.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2007-11
- Volume
- 1117
- Issue
- 1
- Pages
- 209-257
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2029620076
- Cited by
- 391
- References
- 158
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- RUSSELL, R. G. G., XIA, Z., DUNFORD, J. E., OPPERMANN, U., KWAASI, A., HULLEY, P. A., KAVANAGH, K. L., TRIFFITT, J. T., LUNDY, M. W., PHIPPS, R. J., BARNETT, B. L., COXON, F. P., ROGERS, M. J., WATTS, N. B., & EBETINO, F. H. (2007). Bisphosphonates: An Update on Mechanisms of Action and How These Relate to Clinical Efficacy. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1402.089
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
