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Contractility Patterns of Human Leg Lymphatics in Various Stages of Obstructive Lymphedema
Open accessAbstract
In healthy human leg, lymphatics contract spontaneously, rhythmically propelling lymph. The pressures generated by lymphatic contractions constitute the main force for lymph flow. This mechanism is of utmost importance during night rest, anesthesia, and immobilization, as well as in those with damaged peripheral motor neurons. Under physiological conditions, limb muscular activity and position only slightly change lymph flow. In obstructive lymphedema, lymphatic wall muscular fibers become damaged and the spontaneous contractility becomes ineffective in lymph transport because of low generated pressures and lymphatic valve insufficiency. The lymph‐propelling task is taken over by leg muscle contractions. Measuring intralymphatic pressures and flow gives some insight into the mechanism of lymph flow in healthy limbs and loss of this function in lymphedema. This knowledge will be useful in the derivation of rational treatments for lymphedema.
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Measurements in the legs of upright patients reveal intralymphatic pressures with substantially higher peak systolic values than in rodents and which are likely required to propel lymph against hydrostatic columns potentially as high as 100 cmH2O.
“Measurements in the legs of upright patients reveal intralymphatic pressures with substantially higher peak systolic values than in rodents and which are likely required to propel lymph against hydrostatic columns potentially as high as 100 cmH2O (48, 49).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [49]
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Experimental — accuracy not yet measuredCollecting LV contractile dysfunction has been well documented in lymphedema patients.
“Collecting LV contractile dysfunction has been well documented in lymphedema patients (49)”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [49]
Lymphedema can result from genetic mutations in critical genes controlling lymphatic vessel or valve development, surgical disruption of lymphatic networks, and/or impaired pumping of collecting lymphatic vessels.
“Lymphedema is the accumulation of excess interstitial fluid as a result of lymphatic dysfunction, and can result from genetic mutations in critical genes controlling lymphatic vessel or valve development (37), surgical disruption of lymphatic networks (131), and/or impaired pumping of collecting lymphatic vessels (49, 57).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [49]
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Research works printed but not linked: 9
- Olszewski W.L., 1980, Intrinsic contractility of prenodal lymph vessels and lymph flow in human leg, Am. J. Physiol., 239, H775
- Engeset A., 1973, Studies on human peripheral lymph. I. Sampling method, Lymphology, 6, 1
- Olszewski W.L., 1977, Collection and physiological measurements of lymph and interstitial fluid in man, Lymphology, 10, 137
- Sorensen O., 1982, High‐sensitivity optical flowmeter, Lymphology, 15, 29
- 10.1056/NEJM197902083000613 · DOI
- Olszewski W.L., 1979, Intrinsic contractility of leg lymphatics in man: preliminary communication, Lymphology, 12, 81
- 10.1152/ajpheart.01340.2006 · DOI
- Olszewski W.L., 1977, Lymphedema
- 10.1111/j.1749-6632.2002.tb04867.x · DOI
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Transport and Immune Functions of the Lymphatic System.
Davis, M. J., Zawieja, S. D., & King, P. D. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022724-104908 · Cited by 42
Metadata
- Authors
- Olszewski, W. L.
- Affiliations
- Central Clinical Hospital (PL)
- Corresponding author
- Olszewski, Waldemar L.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2008-05
- Volume
- 1131
- Issue
- 1
- Pages
- 110-118
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1995932465
- Cited by
- 86
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- lymphatic contractility, lymph flow, lymphatic pressure, muscle contraction, lymphatic transport
- MeSH terms
- Humans, Leg, Lymph, Lymphatic System, Lymphedema, Muscle Contraction
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