Central Nervous System Regulation of Energy Metabolism: Ghrelin versus Leptin
Open accessAbstract
In this brief review, we introduce some major themes in the regulation of energy, lipid, and glucose metabolism by the central nervous system (CNS). Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS.
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The nervous system coordinates whole-body metabolism by producing neurohormones that act locally and by direct innervation of target tissues.
“Alternatively, the nervous system coordinates whole‐body metabolism not only by the production of neurohormones that act locally, but also by direct innervation of the target tissues 2, 3, 4, 5.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [4]
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References 42 · Cited by 115
- Authors
- Nogueiras, R., Tschöp, M. H., & Zigman, J. M.
- Affiliations
- German Institute of Human Nutrition (DE)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Zigman, Jeffrey M.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2008-04
- Volume
- 1126
- Issue
- 1
- Pages
- 14-19
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- PMC
- PMC2814160
- OpenAlex
- W2047589919
- Cited by
- 115
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 11 · 2015: 9 · 2014: 4 · 2013: 13 · 2012: 14
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK068069)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- central nervous system, energy metabolism, lipid metabolism, glucose metabolism, ghrelin, leptin, neuroendocrine regulation, appetite regulation
- MeSH terms
- Aged, Appetite, Arcuate Nucleus of Hypothalamus, Body Weight, Central Nervous System, Diabetes Mellitus, Energy Metabolism, Glucose, Homeostasis, Humans, Hypothalamus, Obesity, Leptin, Ghrelin
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