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Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors.
Abstract
Concomitant chemoradiotherapy can be used in order to increase both the local and systemic control of solid tumors. The rationale for its use and experimental data for selected chemotherapy drugs are reviewed. Clinical trials have focused on increasing complete response (CR) and survival rates; in addition, improved quality of life by decreasing the use of conventional surgical procedures is being pursued. Both of these goals may have been achieved for some tumors, most notably for anal cell carcinoma. Improved survival with concomitant chemoradiotherapy has also been shown for patients treated on randomized studies for pancreatic, colorectal, small-cell lung, head and neck, and cervical cancer. These results call for the continued investigation of this approach in the laboratory and in the clinic.
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Citations
Cited by
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Risk of Leukemia after Platinum-Based Chemotherapy for Ovarian Cancer
Travis, L. B., Holowaty, E. J., Bergfeldt, K., Lynch, C. F., Kohler, B. A., Wiklund, T., Curtis, R. E., Hall, P., Andersson, M., Pukkala, E., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902043400504 · Cited by 359
Choi, N. C., Carey, R. W., Daly, W., Mathisen, D., Wain, J., Wright, C., Lynch, T., Grossbard, M., & Grillo, H. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.2.712 · Cited by 271
Metadata
- Authors
- Vokes, E. E., & Weichselbaum, R. R.
- Venue
- Journal of Clinical Oncology
- Published
- 1990-05
- Volume
- 8
- Issue
- 5
- Pages
- 911-934
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2278556698
- Cited by
- 364
- References
- 0
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. https://app.cochat.ai/papers/10.1200/jco.1990.8.5.911
- The paper
- Vokes, E. E., & Weichselbaum, R. R. (1990). Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1990.8.5.911
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
