The DOI matches its Crossref record.
Surgery for lung metastases from colorectal cancer: analysis of prognostic factors.
Abstract
PURPOSE: To identify prognostic factors of improved survival after resection of isolated pulmonary metastases (PM) from colorectal cancer. PATIENTS AND METHODS: A retrospective analysis of the records of all patients with PM from colorectal cancer who underwent thoracic surgery with curative intent before December 1992 at a single surgical center was performed. Univariate (log-rank) and multivariate (Cox's model) analyses of survival were used to identify significant prognostic factors. RESULTS: Eighty-six patients with PM from colon (n = 49) or rectal (n = 37) cancer underwent 102 thoracic operations, which included 21 bilateral and 10 incomplete resections. The 5- and 10-year probabilities of survival (Kaplan-Meier) after the first thoracic operation were 24% (95% confidence interval [CI], 15% to 35%) and 20% (95% CI, 13% to 31%), respectively. Sex, age, site of the primary tumor (colon or rectum), disease-free interval (DFI), and previous resection of hepatic metastases were found not to be statistically significant prognostic factors. Complete resection, a limited number ( < two) of PM, and a normal prethoracotomy serum carcinoembryonic antigen (CEA) level were predictors of a longer survival duration by univariate analysis, but only complete resection (P = .024) and preoperative CEA level (P = .001) were identified as independent prognostic factors by multivariate analysis. The estimated 5-year survival rate of patients with a normal prethoracotomy CEA level was 60%, as compared with 4% in cases with elevated ( > 5 ng/mL) CEA level. CONCLUSION: Besides resectability, the prethoracotomy serum CEA level appears the most reliable predictor of survival in patients with isolated PM from colorectal cancer.
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Cited by
Long-term results of lung metastasectomy: Prognostic analyses based on 5206 cases
Pastorino, U., Buyse, M., Friedel, G., Ginsberg, R. J., Girard, P., Goldstraw, P., Johnston, M., McCormack, P., Pass, H., & Putnam, J. B. (1997) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(97)70397-0 · Cited by 1,529
Self-citationLabianca, R., Beretta, G. D., Kildani, B., Milesi, L., Merlin, F., Mosconi, S., Pessi, M. A., Prochilo, T., Quadri, A., Gatta, G., et al. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.01.010 · Cited by 409
Surgical treatment of hepatic and pulmonary metastases from colorectal cancers
Regnard, J.-F., Grunenwald, D., Spaggiari, L., Girard, P., Elias, D., Ducreux, M., Baldeyrou, P., & Levasseur, P. (1998) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(98)00269-0 · Cited by 180
Self-citationIs resection of pulmonary and hepatic metastases warranted in patients with colorectal cancer?
Robinson, B. J., Rice, T. W., Strong, S. A., Rybicki, L. A., & Blackstone, E. H. (1999) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(99)70470-8 · Cited by 111
Metadata
- Authors
- Girard, P., Ducreux, M., Baldeyrou, P., Rougier, P., Le Chevalier, T., Bougaran, J., Lasser, P., Gayet, B., Ruffié, P., & Grunenwald, D.
- Venue
- Journal of Clinical Oncology
- Published
- 1996-07
- Volume
- 14
- Issue
- 7
- Pages
- 2047-2053
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2108973323
- Cited by
- 187
- References
- 0
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Girard, P., Ducreux, M., Baldeyrou, P., Rougier, P., Le Chevalier, T., Bougaran, J., Lasser, P., Gayet, B., Ruffié, P., & Grunenwald, D. (1996). Surgery for lung metastases from colorectal cancer: analysis of prognostic factors. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1996.14.7.2047
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