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Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation.
Abstract
PURPOSE: To determine if fluorouracil (FUra) has different mechanisms of action as a function of the dose schedule used. DESIGN: The preclinical and clinical literature relating toxicity and antitumor effects of FUra as a function of its dose schedule, with and without modulating agents, was reviewed. RESULTS: The data support the hypothesis that FUra may be considered to be two different drugs, depending on its dose schedule (bolus v continuous infusion [CI]). CONCLUSION: These results suggest that additional therapeutic benefit may be obtained from FUra regimens by (1) appropriate schedule-dependent modulation, (2) the sequential or alternating use of cycles of bolus followed by cycles of CI FUra appropriately modulated, or (3) hybrid regimens, ie, those that contain both pulse and CI schedules.
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Rougier, P., Van Cutsem, E., Bajetta, E., Niederle, N., Possinger, K., Labianca, R., Navarro, M., Morant, R., Bleiberg, H., Wils, J., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03085-2 · Cited by 992
Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): A review
Malet-Martino, M., & Martino, R. (2002) · The Oncologist · doi:10.1634/theoncologist.7-4-288 · Cited by 382
Noordhuis, P., Holwerda, U., Van der Wilt, C. L., Van Groeningen, C. J., Smid, K., Meijer, S., Pinedo, H. M., & Peters, G. J. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh264 · Cited by 264
(2001) · PubMed · Cited by 194
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance
Humeniuk, R., Menon, L. G., Mishra, P. J., Gorlick, R., Sowers, R., Rode, W., Pizzorno, G., Cheng, Y.-C., Kemeny, N., Bertino, J. R., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0716 · Cited by 50
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Metadata
- Authors
- Sobrero, A. F., Aschele, C., & Bertino, J. R.
- Venue
- Journal of Clinical Oncology
- Published
- 1997-01
- Volume
- 15
- Issue
- 1
- Pages
- 368-381
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1811602282
- Cited by
- 336
- References
- 0
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation. https://app.cochat.ai/papers/10.1200/jco.1997.15.1.368
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- Sobrero, A. F., Aschele, C., & Bertino, J. R. (1997). Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1997.15.1.368
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
