Cited by 294Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsOvarian cancer diagnosis and treatment

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Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.

Meyers, P A, Gorlick, R, Heller, G, Casper, E, Lane, J, Huvos, A G, Healey, J H·1998·Journal of Clinical Oncology

DOI 10.1200/jco.1998.16.7.2452

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Abstract

PURPOSE: It has been observed previously in osteosarcoma (OS) that the degree of necrosis of the resected primary tumor following a period of preoperative chemotherapy is predictive of subsequent event-free survival (EFS). The aim of this study was to determine if more intensive preoperative chemotherapy would increase the proportion of patients with a good histologic response and improve EFS. PATIENTS AND METHODS: Seventy-three patients with OS were treated at Memorial-Sloan Kettering Cancer Center (MSKCC) on the T12 protocol between 1986 and 1993. Patients were randomized between therapy based on the T10 protocol and therapy with more intensive preoperative chemotherapy. The more intensive preoperative regimen consisted of two courses of cisplatin (CDDP) and doxorubicin (DOX) in addition to the usual preoperative regimen of high-dose methotrexate (HD MTX) and bleomycin, cyclophosphamide, and dactinomycin (BCD). RESULTS: The regimen with more intensive preoperative chemotherapy achieved a modest increase in the proportion of patients with a good histologic response (44% with a grade III or IV histologic response v 37% in the control arm, 33% with grade IV histologic response v 13% in the control arm). EFS continued to correlate with histologic response. The actuarial 5-year EFS in patients with localized disease was 78% for the regimen with more intensive preoperative chemotherapy and 73% for the control arm. CONCLUSION: Despite modest increases in the proportion of patients with good histologic response with intensified preoperative chemotherapy, no improvement in EFS was observed.

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Authors: Meyers, P. A., Gorlick, R., Heller, G., Casper, E., Lane, J., Huvos, A. G., & Healey, J. H.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Meyers, P A
Gorlick, R
Heller, G
Lane, J
Healey, J H
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 1998-07
Volume: 16
Issue: 7
Pages: 2452-2458
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.1998.16.7.2452
OpenAlex: W1946181835
Cited by: 294
References: 18
Citations by year: 2025: 1 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 22 · 2013: 16 · 2012: 8
FWCI: 7.03
Type: journal article
Language: en
Open access: closed
Locations: Journal of Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: Memorial Sloan-Kettering Cancer Center
National Cancer Institute (CA-09512, T32CA009512)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
Keywords: osteosarcoma, neoadjuvant chemotherapy, chemotherapy intensification, cisplatin, doxorubicin, high-dose methotrexate, bleomycin, cyclophosphamide, actinomycin D, histological response, tumor necrosis, event-free survival
MeSH terms: Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Bleomycin, Bone Neoplasms, Child, Child, Preschool, Cisplatin, Cyclophosphamide, Dactinomycin, Doxorubicin, Female, Humans, Male, Methotrexate, Necrosis, Osteosarcoma, Time Factors, Treatment Outcome, Chemotherapy, Adjuvant, Disease-Free Survival

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Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.

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