The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Randomized, Dose-Escalation Study of SD/01 Compared With Daily Filgrastim in Patients Receiving Chemotherapy
Abstract
PURPOSE: To explore the use of SD/01 (a polyethylene glycol–conjugated filgrastim shown in preclinical studies to have a prolonged half-life) in patients with chemotherapy-induced neutropenia. PATIENTS AND METHODS: Thirteen patients with non–small-cell lung cancer were randomized to receive daily filgrastim (5 μg/kg/d) or a single injection of SD/01 (30, 100, or 300 μg/kg) 2 weeks before chemotherapy and again 24 hours after administration of carboplatin and paclitaxel. Pharmacodynamic, pharmacokinetic, and safety analyses were performed. RESULTS: Peak serum concentrations of SD/01 and the duration of increased serum concentrations were dependent on the SD/01 dose. SD/01 concentrations remained increased longer in patients with chemotherapy-induced neutropenia. Prechemotherapy median absolute neutrophil counts (ANCs) in patients receiving SD/01 were increased in a dose-dependent fashion, with the duration of this effect also being dose dependent. After chemotherapy, median ANC nadirs were similar in the filgrastim cohort and the cohort receiving SD/01 30 μg/kg, with higher nadirs seen in the cohorts receiving SD/01 100 or 300 μg/kg. Dose-limiting toxicities were not noted. CD34+ cells were mobilized in all cohorts. CONCLUSION: A single dose of SD/01 increases the serum concentration of SD/01 for several days in a dose-dependent fashion and is not associated with significant toxicity. The effects of SD/01 on ANC and CD34+ cell mobilization are comparable or greater than those achieved with daily filgrastim. The self-regulation of this molecule provides a potential therapeutic advantage in a variety of clinical settings associated with neutropenia.
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Crawford, J., Ozer, H., Stoller, R., Johnson, D., Lyman, G., Tabbara, I., Kris, M., Grous, J., Picozzi, V., Rausch, G., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107183250305 · Cited by 1,390
Self-citationFilgrastim (r-metHuG-CSF): the first 10 years
Welte, K., Gabrilove, J., Bronchud, M., Platzer, E., & Morstyn, G. (1996) · Blood · doi:10.1182/blood.v88.6.1907.bloodjournal8861907 · Cited by 599
Trillet-Lenoir, V., Green, J., Manegold, C., Von Pawel, J., Gatzemeier, U., Lebeau, B., Depierre, A., Johnson, P., Decoster, G., Tomita, D., et al. (1993) · European Journal of Cancer · doi:10.1016/0959-8049(93)90376-q · Cited by 543
Pettengell, R., Gurney, H., Radford, J., Deakin, D., James, R., Wilkinson, P., Kane, K., Bentley, J., & Crowther, D. (1992) · Blood · doi:10.1182/blood.v80.6.1430.1430 · Cited by 440
The uses and properties of PEG-linked proteins.
Delgado, C., Francis, G. E., & Fisher, D. (1992) · PubMed · Cited by 420
Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin
Massberg, S., Enders, G., Leiderer, R., Eisenmenger, S., Vestweber, D., Krombach, F., & Messmer, K. (1998) · Blood · doi:10.1182/blood.v92.2.507 · Cited by 393
Frei, E., ELIAS, A. D., Wheeler, C., et al. (1998) · PubMed · Cited by 105
Cited by
Green, M. D., Koelbl, H., Baselga, J., Galid, A., Guillem, V., Gascon, P., Siena, S., Lalisang, R. I., Samonigg, H., Clemens, M. R., et al. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg019 · Cited by 586
Holmes, F. A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.727 · Cited by 537
Mono-N-terminal poly(ethylene glycol)–protein conjugates
Kinstler, O., Molineux, G., Treuheit, M., Ladd, D., & Gegg, C. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00023-6 · Cited by 306
Filgrastim improves survival in lethally irradiated nonhuman primates
Farese, A. M., Cohen, M. V., Katz, B. P., Smith, C. P., Gibbs, A., Cohen, D. M., & MacVittie, T. J. (2013) · Radiation Research · doi:10.1667/rr3049.1 · Cited by 187
Pegfilgrastim improves survival of lethally irradiated nonhuman primates
Hankey, K. G., Farese, A. M., Blaauw, E. C., Gibbs, A. M., Smith, C. P., Katz, B. P., Tong, Y., Prado, K. L., & MacVittie, T. J. (2015) · Radiation Research · doi:10.1667/rr13940.1 · Cited by 129
Metadata
- Authors
- Johnston, E., Crawford, J., Blackwell, S., Bjurstrom, T., Lockbaum, P., Roskos, L., Yang, B.-B., Gardner, S., Miller-Messana, M. A., Shoemaker, D., Garst, J., & Schwab, G.
- Venue
- Journal of Clinical Oncology
- Published
- 2000-07-01
- Volume
- 18
- Issue
- 13
- Pages
- 2522-2528
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2269955197
- Cited by
- 264
- References
- 7
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Randomized, Dose-Escalation Study of SD/01 Compared With Daily Filgrastim in Patients Receiving Chemotherapy. https://app.cochat.ai/papers/10.1200/jco.2000.18.13.2522
- The paper
- Johnston, E., Crawford, J., Blackwell, S., Bjurstrom, T., Lockbaum, P., Roskos, L., Yang, B.-B., Gardner, S., Miller-Messana, M. A., Shoemaker, D., Garst, J., & Schwab, G. (2000). Randomized, Dose-Escalation Study of SD/01 Compared With Daily Filgrastim in Patients Receiving Chemotherapy. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2000.18.13.2522
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
