The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Improving Survival Without Reducing Quality of Life in Small-Cell Lung Cancer Patients by Increasing the Dose-Intensity of Chemotherapy With Granulocyte Colony-Stimulating Factor Support: Results of a British Medical Research Council Multicenter Randomized Trial
Abstract
PURPOSE: The treatment of small-cell lung cancer patients with good performance status aims to improve survival. Dose-intensification could be a way to achieve improved survival but can be limited by neutropenia and thrombocytopenia. Preliminary, nonrandomized feasibility studies showed that doxorubicin, cyclophosphamide, and etoposide (ACE) could be given every 2 (instead of the usual 3) weeks with granulocyte colony-stimulating factor (G-CSF) (lenograstim; Chugai-Rhône-Poulenc, Tokyo, Japan) support. The present multicenter randomized trial was designed to examine whether such dose-intensification improves survival while maintaining acceptable toxicity levels. PATIENTS AND METHODS: All patients were randomized to receive six cycles of ACE either every 3 weeks (control [C] group) or every 2 weeks with G-CSF (G group). The standard dose-intensity of ACE was increased by 50% in group G. RESULTS: Four hundred and three patients (G group: n = 201; C group: n = 202) were randomized. The received dose-intensity was 34% higher in the G group than in the C group. Complete response rates were 40% for the G group and 28% for the C group (P = .02), and overall rates were 78% for the G group and 79% for the C group. Survival was longer in the G group (hazard ratio = 0.80; 95% confidence interval, 0.65 to 0.99; P = .04), survival rates for the G and C groups being 47% and 39% at 12 months and 13% and 8% at 24 months, respectively. Metastasis-free survival, nonhematologic toxicity, and quality of life were similar in the two groups. In the G group, there was less neutropenia but more thrombocytopenia and more frequent blood and platelet transfusions. CONCLUSION: Increasing the dose-intensity of ACE with G-CSF support improved survival while maintaining acceptable toxicity.
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on behalf of the Medical Research Council (MRC) Lung Cancer Working Party, Hopwood, P., & Stephens, R. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.124 · Cited by 192
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Cited by
Smith, T. J., Khatcheressian, J., Lyman, G. H., Ozer, H., Armitage, J. O., Balducci, L., Bennett, C. L., Cantor, S. B., Crawford, J., Cross, S. J., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.4451 · Cited by 1,636
van Meerbeeck, J. P., Fennell, D. A., & De Ruysscher, D. K. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60165-7 · Cited by 1,237
Ozer, H., Armitage, J. O., Bennett, C. L., Crawford, J., Demetri, G. D., Pizzo, P. A., Schiffer, C. A., Smith, T. J., Somlo, G., Wade, J. C., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.20.3558 · Cited by 1,044
Pedrazzoli, P., Ledermann, J. A., Lotz, J.-P., Leyvraz, S., Aglietta, M., Rosti, G., Champion, K. M., Secondino, S., Selle, F., Ketterer, N., et al. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl044 · Cited by 655
Holmes, F. A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.727 · Cited by 537
Metadata
- Authors
- Thatcher, N., Girling, D. J., Hopwood, P., Sambrook, R. J., Qian, W., Stephens, R. J., & for the Medical Research Council Lung Cancer Working Party
- Venue
- Journal of Clinical Oncology
- Published
- 2000-01-01
- Volume
- 18
- Issue
- 2
- Pages
- 395-395
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2173643829
- Cited by
- 224
- References
- 1
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Thatcher, N., Girling, D. J., Hopwood, P., Sambrook, R. J., Qian, W., Stephens, R. J., & for the Medical Research Council Lung Cancer Working Party. (2000). Improving Survival Without Reducing Quality of Life in Small-Cell Lung Cancer Patients by Increasing the Dose-Intensity of Chemotherapy With Granulocyte Colony-Stimulating Factor Support: Results of a British Medical Research Council Multicenter Randomized Trial. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2000.18.2.395
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
