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Symptoms of Posttraumatic Stress in Young Adult Survivors of Childhood Cancer
Abstract
PURPOSE: This study assessed the prevalence of posttraumatic stress symptoms in young adult survivors of childhood cancer and the association of posttraumatic stress with anxiety, adjustment, perceptions of illness and treatment, and medical data extracted from oncology records. PATIENTS AND METHODS: Seventy-eight young adults (ages 18 to 40 years) who had been treated for childhood cancer completed questionnaires and psychiatric interviews assessing posttraumatic stress, anxiety, perceptions of their illness and treatment, and symptoms of psychologic distress. Data on treatment intensity and severity of medical late effects were collected via chart review. RESULTS: Of the patient sample, 20.5% met American Psychiatric Association Diagnostic and Statistical Manual criteria for posttraumatic stress disorder (PTSD) at some point since the end of their treatment. Clinically significant levels of intrusive (9%) and avoidant (16.7%) symptoms were reported. Participants also reported elevated state and trait anxiety. Participants with PTSD reported higher perceived current life threat, more intense treatment histories, and higher (and clinically significant) levels of psychologic distress than those who did not have PTSD. CONCLUSION: One-fifth of this sample of young adult survivors of childhood cancer met criteria for a diagnosis of PTSD, with clinically significant symptoms of intrusion and avoidance reported. As in other samples, PTSD in young adult survivors was associated with anxiety and other psychologic distress. Survivors’ perceptions of treatment and its effects were more highly associated with posttraumatic stress than were more objective medical data. The data suggest that cancer-related posttraumatic stress may emerge in young adulthood and may affect the achievement of developmental milestones and orientation toward health care.
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“Although the literature in this domain mostly stems from comparatively small-sized studies, results indeed highlighted that subjective appraisals regarding the cancer experience and its aftermath are stronger predictors of psychosocial functioning than objective medical data [10-12].”
From Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study (2024) · cites this paper as [10]
In the citing paper
“These results are in line with previous studies demonstrating the importance of subjective appraisals and social support in predicting CCS' psychosocial outcomes [10-13].”
From Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study (2024) · cites this paper as [10]
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Metadata
- Authors
- Hobbie, W. L., Stuber, M., Meeske, K., Wissler, K., Rourke, M. T., Ruccione, K., Hinkle, A., & Kazak, A. E.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Venue
- Journal of Clinical Oncology
- Published
- 2000-12-15
- Volume
- 18
- Issue
- 24
- Pages
- 4060-4066
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2098609244
- Cited by
- 357
- References
- 31
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 10 · 2017: 15 · 2016: 13 · 2015: 18 · 2014: 13 · 2013: 18 · 2012: 17
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- post-traumatic stress disorder, childhood cancer survivors, young adults, anxiety, psychological distress, intrusion symptoms, avoidance symptoms, perceived life threat, treatment intensity, late effects of cancer treatment, developmental milestones
- MeSH terms
- Adolescent, Adult, Female, Humans, Male, Manifest Anxiety Scale, Neoplasms, Psychological Tests, Stress Disorders, Post-Traumatic
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