DNA Microarrays in Clinical Oncology
Abstract
ABSTRACT: Aberrant gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently, DNA microarrays have been used to obtain global views of human cancer gene expression and to identify genetic markers that might be important for diagnosis and therapy. We review clinical applications of these novel tools, discuss some important recent studies, identify promising avenues of research in this emerging field of study, and discuss the likely impact that expression profiling will have on clinical oncology.
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Multiple genetic alterations are involved in the development and progression of esophageal cancer.
“Multiple genetic alterations are involved in the development and progression of esophageal cancer”
From Prediction of the response to chemotherapy in advanced esophageal cancer by gene expression profiling of biopsy samples (2010) · cites this paper as [9]
These genetic aberrations may affect the expression of a large number of genes.
“these aberrations may affect the expression of large number of genes (8,9).”
From Prediction of the response to chemotherapy in advanced esophageal cancer by gene expression profiling of biopsy samples (2010) · cites this paper as [9]
Cites
ROWLEY, J. D. (1973) · Nature · doi:10.1038/243290a0 · Cited by 4,291 · see citing works
Khan, J., Wei, J. S., Ringnér, M., Saal, L. H., Ladanyi, M., Westermann, F., Berthold, F., Schwab, M., Antonescu, C. R., Peterson, C., et al. (2001) · Nature Medicine · doi:10.1038/89044 · Cited by 2,644 · see citing works
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Takemasa (2010) · International Journal of Oncology · doi:10.3892/ijo_00000763 · Cited by 31 · see citing works
Gene expression of colorectal cancer: Preoperative genetic diagnosis using endoscopic biopsies
Komori, T., Takemasa, I., Yamasaki, M., Motoori, M., Kato, T., Kikkawa, N., Kawaguchi, N., Ikeda, M., Yamamoto, H., Sekimoto, M., et al. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.2.367 · Cited by 16 · see citing works
- Authors
- Ramaswamy, S., & Golub, T. R.
- Affiliations
- Harvard University (US)
- ORCID
- Golub, Todd R.
- Venue
- Journal of Clinical Oncology
- Published
- 2002-04-01
- Volume
- 20
- Issue
- 7
- Pages
- 1932-1941
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2144894933
- Cited by
- 379
- References
- 2
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 3 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 10
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- DNA microarrays, gene expression profiling, cancer gene expression, aberrant gene expression, tumor initiation and progression, genetic markers, cancer diagnosis, cancer therapy, clinical oncology
- MeSH terms
- Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
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