The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Response of Retinoblastoma With Vitreous Tumor Seeding to Adenovirus-Mediated Delivery of Thymidine Kinase Followed by Ganciclovir
Abstract
Purpose: To evaluate the feasibility and safety of adenovirus-mediated gene therapy as a treatment for tumor seeds in the vitreous of children with retinoblastoma. Patients and Methods: An Institutional Biosafety Committee–, Institutional Review Board–, Recombinant DNA Advisory Committee–, and US Food and Drug Administration–approved phase I study used intrapatient dose escalation of adenoviral vector containing a herpes simplex thymidine kinase gene (AdV-TK) followed by systemic administration of ganciclovir to treat bilateral retinoblastoma with vitreous tumor seeding refractory to standard therapies. Vitreous tumor seeds were treated by intravitreous injection of AdV-TK adjacent to disease sites. Each injection was followed by ganciclovir delivered intravenously every 12 hours for 7 days. Results: Eight patients with vitreous tumor seeds were enrolled. One patient who was treated with 10 8 viral particles (vp) had resolution of the tumor seeds around the injection site. The seven patients who were treated with doses ≥ 10 10 vp had resolution of their vitreous tumor seeds documented by fundoscopy. Toxicity included mild inflammation at 10 10 vp and moderate inflammation, corneal edema, and increased intraocular pressure at 10 11 vp. One patient was free of active vitreous tumor seeds 38 months after therapy. There has been no evidence of extraocular spread of tumor along the needle tract in any patient. Conclusion: AdV-TK followed by ganciclovir can be administered safely to children with retinoblastoma. Suicide gene therapy may contribute to the treatment of children with retinoblastoma tumor seeds in the vitreous, a resistant complication of retinoblastoma.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The retinoblastoma cohort consisted of eight patients, five of whom developed ocular inflammation even though there was no measurable humoral or cellular immune response [65].”
From Immune responses to gene editing by viral and non-viral delivery vectors used in retinal gene therapy (2022) · cites this paper as [65]
Citations
Cites
Mutation and cancer: statistical study of retinoblastoma
Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612
Gene therapy restores vision in a canine model of childhood blindness
Acland, G. M., Aguirre, G. D., Ray, J., Zhang, Q., Aleman, T. S., Cideciyan, A. V., Pearce-Kelling, S. E., Anand, V., Zeng, Y., Maguire, A. M., et al. (2001) · Nature Genetics · doi:10.1038/ng0501-92 · Cited by 1,202
Chen, S. H., Shine, H. D., Goodman, J. C., Grossman, R. G., & Woo, S. L. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3054 · Cited by 476
Chemotherapy Plus Local Treatment in the Management of Intraocular Retinoblastoma
Murphree, A. L. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100140548005 · Cited by 471
Chemotherapy With Focal Therapy Can Cure Intraocular Retinoblastoma Without Radiotherapy
Gallie, B. L. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100140521001 · Cited by 412
Chemoreduction in the Initial Management of Intraocular Retinoblastoma
Shields, C. L. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100140530002 · Cited by 358
In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial
Herman, J. R., Adler, H. L., Aguilar-Córdova, E., Rojas‐Martínez, A., Woo, S. L. C., Timme, T. L., Wheeler, T. M., Thompson, T. C., & Scardino, P. T. (1999) · Human Gene Therapy · doi:10.1089/10430349950018229 · Cited by 301
Trask, T., Trask, R. P., Aguilar-Córdova, E., Shine, H. D., Wyde, P. R., Goodman, J. C., Hamilton, W. J., Rojas‐Martínez, A., Chen, S., Woo, S. L. C., et al. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0030 · Cited by 262
Aa, E., Saavedra, A., Zhang, H., Kucharczuk, J. C., Dc, S., Fishman, G. I., Km, A., Kaiser, L. R., & Albelda, S. (1996) · PubMed · Cited by 259
Incidence of Second Neoplasms in Patients with Bilateral Retinoblastoma
Roarty, J. D., McLean, I. W., & Zimmerman, L. E. (1988) · Ophthalmology · doi:10.1016/s0161-6420(88)32971-4 · Cited by 254
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–142 of 142
Gene Therapy for Ocular Diseases
Kim, B. J., & Waheed, N. K. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780195326147.003.0052 · Cited by 3
Intraocular seeds in retinoblastoma: A review of classification, management, and outcomes
Sen, M., Munier, F. L., & Honavar, S. G. (2025) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2025.08.008 · Cited by 2
[Gene therapy for hereditary ophthalmological diseases: Advances and future perspectives].
Chacon-Camacho, O. F., Astorga-Carballo, A., & Zenteno, J. C. (2015) · PubMed · Cited by 2
Gene Therapy for Retinal Disease
Bennett, J., & Maguire, A. M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00034-5 · Cited by 2
Abramson, D. H. (2023) · Ophthalmic Genetics · doi:10.1080/13816810.2023.2189948 · Cited by 2
“066 cc), UBM is used to avoid injecting directly into a tumor mass, and cryo is applied to the needle before and when the needle is retracted to “seal” the hole when the needle is removed (Figure 2) (19).”
Multidisciplinary Management of Retinoblastoma: Diagnosis, Treatment, and Future Direction
Ghisoli, M. L., Zage, P. E., Herzog, C., Chevez-Barrios, P., Chintagumpala, M., Hurwitz, R. L., Mahajan, A., & Gombos, D. S. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0374-7_14 · Cited by 2
“Importantly, the intraocular injections did not result in the spread of the tumor through the needle track, suggesting that other therapies could be delivered by intraocular injection [51].”
BackgroundSelf-citationGehlbach, P. L., Chuck, R. S. H., Park, C., & Park, C. Y. (2012) · Molecular Imaging · doi:10.2310/7290.2011.00053 · Cited by 1
Treatment of Intraocular Retinoblastoma
Wilson, M. W. (2009) · Pediatric oncology · doi:10.1007/978-0-387-89072-2_7 · Cited by 1
Gene Therapy for the Treatment of Cancer: From Laboratory to Bedside
Ramos, C. A., Savoldo, B., & Dotti, G. (2015) · CRC Press eBooks · doi:10.1201/b18002-49 · Cited by 1
Gene therapy for Stargardt and other ABCA4-related diseases: lessons from RPE65-LCA trials
Silva, N. F. A. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1
Michalakis, S., Gerhardt, M.-J., Priglinger, C., & Priglinger, S. G. (2021) · Springer eBooks · doi:10.1007/978-3-319-90495-5_150-1 · Cited by 1
Intravitreal Chemotherapy for Retinoblastoma
Channa, R., Yohannan, J., & Aronow, M. E. (2016) · Advances in Ophthalmology and Optometry · doi:10.1016/j.yaoo.2016.03.010 · Cited by 1
An optimized gene transfection system in WERI-Rb1 cells
Liu, Y., Fan, Z., Li, K. V., Deng, F., Xiong, Y., Liang, M., & Ge, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3058 · Cited by 1
“A few types of transgene vectors have been randomly adopted for retinoblastoma gene transfection, including the adenoviral vector (6,7), the liposome (12), and some uncommon vectors such as the encephalomyocarditis virus (13).”
Liu, A. S., Ildefonso, C. J., Bond, W. S., Hurwitz, M. Y., & Hurwitz, R. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236175 · Cited by 1
“Gene therapy has proven to be particularly successful in the eye [1, 2].”
BackgroundSelf-citationMichalakis, S., Gerhardt, M.-J., Priglinger, C., & Priglinger, S. G. (2022) · Springer eBooks · doi:10.1007/978-3-030-42634-7_150 · Cited by 1
Tumor Models of Retinoblastoma: In Vivo, Ex Vivo, and In Vitro Models
Sen, R., Thathapudi, N. C., Sharma, D., Shome, I., Singh, S. P., Magisetty, O., & Jangamreddy, J. R. (2023) · Handbook of Animal Models and its Uses in Cancer Research · doi:10.1007/978-981-19-3824-5_30 · Cited by 1
PHYSIOCHEMICAL STABILITY AND MASS SPECTROMETRIC ANALYSIS OF GEMINI SURFACTANT-BASED LIPOPLEXES
Mohammed‐Saeid, W. (2012) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1
Angiogenic Gene Therapy for the Treatment of Retinopathies
Jones, J. M., McFarland, T. J., & Stout, J. T. (2010) · Springer eBooks · doi:10.1007/978-90-481-9495-7_3
“Years of study on the regulatory factors involved in this cascade have resulted in the generation of multiple potential targets for intervention ( Campochiaro 2007; Stout 2006).”
BackgroundNucleic acid delivery: reports from the search of the Magic Bullet
Viola, J. R. (2011) · Figshare
Martínez, J. M.-Q. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
A New Vision of Mesenchymal Stromal Cells
Hurwitz, R. L. (2012) · Molecular Therapy · doi:10.1038/mt.2012.221
Self-citationAdenovirus gene therapy for pediatric cancers: Shall we gather at the liver?
Geller, J. I., & Cripe, T. P. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22033
“Clinical trials have shown viruses can be given to pediatric patients safely [25], but there have only been faint hints of efficacy, as viral”
BackgroundA Review on Local Chemotherapy for Treatment of Retinoblastoma
Ghassemi, F., Abdehag, M., Roohipoor, R., Karkhaneh, R., & Ahmadabadi, M. N. (2011)
EUROPEAN SCHOOL OF MOLECULAR MEDICINE
Napoli, S. D. (2010)
Francis, J. H. (2015) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-3-319-19467-7_4
Correction of Pathological Morphofunctional Changes in the Mammalian Retina
Purnyn, H. E. (2015) · Neurophysiology · doi:10.1007/s11062-016-9549-y
Progress and Prospects in Ocular Gene Therapy
Liu, X., Rasmussen, C. A., Bennett, J., Brandt, C. R., Gabelt, B. T., & Kaufman, P. L. (2008) · Elsevier eBooks · doi:10.1016/b978-012370585-3.50020-0
Gene Transfer to the Skin by Physical Methods of Delivery
Donate, A., & Heller, R. F. (2017) · Springer eBooks · doi:10.1007/978-3-662-53273-7_29
Wylie, F. J. (2006) · Australian life scientist
Changing Trends in Retinoblastoma Management and What Is in Store for the Future
Berry, J. L. (2019) · Springer eBooks · doi:10.1007/978-981-15-0395-5_3
Dome, J. S., Galindo, C. R., Spunt, S. L., & Santana, V. M. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-2865-7.00095-3
Intravitreal injections in retinoblastoma treatment
Макаревич, О. О. (2020) · Vestnik of Vitebsk State Medical University · doi:10.22263/2312-4156.2020.3.7
Schepelmann, S., Niculescu‐Duvaz, I., & Springer, C. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-470-4_18
Kim, M. E., Xu, L., Prabakar, R. K., Shen, L., Peng, C., Kühn, P., Gai, X., Hicks, J. B., & Berry, J. L. (2021) · doi:10.3791/62939-v
Estlin, E. J., Doz, F., & Dyer, M. A. (2010) · Pediatric Hematology and Oncology · doi:10.1002/9781444315134.ch18
Mukai, S., Grabowski, E. F., Leiderman, Y. I., & Kiss, S. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3431-5.00016-9
Amendola, B. E. (2008) · Medical radiology · doi:10.1007/978-3-540-77385-6_40
Therapy for Vitreous Seeding Caused by Retinoblastoma. A Review
Lapka, M., & Straňák, Z. (2023) · Czech and Slovak Ophthalmology · doi:10.31348/2023/35
Trends in basic science research in interventional radiology
Lee, E. W., Xing, M., & Kee, S. T. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-1221-2.00015-5
Clinical Facts on Retinoblastoma
Muluh, T. A. (2024) · Clinical Cancer Drugs · doi:10.2174/012212697x305434240807182426
Needlefish-related orbital foreign body – two illustrative cases and literature review
Loveridge‐Easther, C., Henry, M., Mataka, D., Bhatia, K., Olsson, G., & Tumuluri, K. (2026) · Orbit · doi:10.1080/01676830.2026.2706069
Metadata
- Authors
- Chévez-Barrios, P., Chintagumpala, M., Mieler, W., Paysse, E., Boniuk, M., Kozinetz, C., Hurwitz, M. Y., & Hurwitz, R. L.
- Affiliations
- From the Departments of Pathology, Ophthalmology, and Pediatrics, Texas Children's Cancer Center; the Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital; and the Methodist Hospital, Houston, TX
- Houston Methodist (US)
- Venue
- Journal of Clinical Oncology
- Published
- 2005-11-01
- Volume
- 23
- Issue
- 31
- Pages
- 7927-7935
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2166510225
- Cited by
- 143
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 9 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 5 · 2012: 10
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R21CA097762, CA97762)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- retinoblastoma, adenoviral vector, herpes simplex thymidine kinase, ganciclovir, suicide gene therapy, gene therapy toxicity, pediatric retinoblastoma, intravitreal injection, dose escalation
- MeSH terms
- Adenoviruses, Human, Antiviral Agents, Child, Combined Modality Therapy, Feasibility Studies, Genetic Vectors, Humans, Neoplasm Recurrence, Local, Neoplasm Seeding, Retinoblastoma, Thymidine Kinase, Vitreous Body, Genetic Therapy, Ganciclovir, Gene Transfer Techniques, Retinal Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
