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Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial
Open accessAbstract
Purpose: To evaluate the efficacy of long-term nontunneled silicone catheters impregnated with minocycline and rifampin (M-R) in reducing catheter-related bloodstream infections. Patients and Methods: This prospective, randomized, double-blind clinical trial was conducted at M.D. Anderson Cancer Center, a tertiary care hospital in Houston, TX. All patients in the trial had a malignancy. Results: Between September 1999 and May 2002, 356 assessable catheters were used: 182 M-R and 174 nonimpregnated. The patients' characteristics were comparable between the two study groups. The mean (± standard deviation) duration of catheterization with M-R catheters was comparable to that of nonimpregnated catheters (66.21 ± 30.88 v 63.01 ± 30.80 days). A total of 17 catheter-related bloodstream infections occurred during the course of the study. Three were associated with the use of M-R catheters and 14 were associated with the nonimpregnated catheters, with a rate of catheter-related bloodstream infection of 0.25 and 1.28/1,000 catheter-days, respectively (P = .003). Gram-positive cocci accounted for the majority of the organisms causing the infections. There were no allergic reactions associated with M-R catheters. Conclusion: Long-term nontunneled central venous catheters impregnated with minocycline and rifampin are efficacious and safe in reducing catheter-related bloodstream infections in cancer patients.
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Cited by
Guidelines for the Prevention of Intravascular Catheter-related Infections
O'Grady, N. P., Alexander, M., Burns, L. A., Dellinger, E. P., Garland, J., Heard, S. O., Lipsett, P. A., Masur, H., Mermel, L. A., Pearson, M. L., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir257 · Cited by 4,699
Self-citationA review of the biomaterials technologies for infection-resistant surfaces
Campoccia, D., Montanaro, L., & Arciola, C. R. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.089 · Cited by 1,358
Guidelines for the prevention of intravascular catheter-related infections
O'Grady, N. P., Alexander, M., Burns, L. A., Dellinger, E. P., Garland, J., Heard, S. O., Lipsett, P. A., Masur, H., Mermel, L. A., Pearson, M. L., et al. (2011) · American Journal of Infection Control · doi:10.1016/j.ajic.2011.01.003 · Cited by 1,066
Self-citationO'Grady, N. P., Alexander, M., Burns, L. A., Dellinger, E. P., Garland, J., Heard, S. O., Lipsett, P. A., Masur, H., Mermel, L. A., Pearson, M. L., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir138 · Cited by 560
Self-citationStrategies to Prevent Central Line–Associated Bloodstream Infections in Acute Care Hospitals
Marschall, J., Mermel, L. A., Classen, D., Arias, K. M., Podgorny, K., Anderson, D. J., Burstin, H., Calfee, D. P., Coffin, S. E., Dubberke, E. R., et al. (2008) · Infection Control & Hospital Epidemiology · doi:10.1086/591059 · Cited by 458
Metadata
- Authors
- Hanna, H., Benjamin, R., Chatzinikolaou, I., Alakech, B., Richardson, D., Mansfield, P., Dvorak, T., Munsell, M. F., Darouiche, R., Kantarjian, H., & Raad, I.
- Venue
- Journal of Clinical Oncology
- Published
- 2004-08-01
- Volume
- 22
- Issue
- 15
- Pages
- 3163-3171
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2127807727
- Cited by
- 191
- References
- 0
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial. https://app.cochat.ai/papers/10.1200/jco.2004.04.124
- The paper
- Hanna, H., Benjamin, R., Chatzinikolaou, I., Alakech, B., Richardson, D., Mansfield, P., Dvorak, T., Munsell, M. F., Darouiche, R., Kantarjian, H., & Raad, I. (2004). Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2004.04.124
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