The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Hyperbaric Oxygen Therapy for Radionecrosis of the Jaw: A Randomized, Placebo-Controlled, Double-Blind Trial From the ORN96 Study Group
Abstract
Purpose: To determine the efficacy and safety of hyperbaric oxygen therapy (HBO) for overt mandibular osteoradionecrosis. Patients and Methods: This prospective, multicenter, randomized, double-blind, placebo-controlled trial was conducted at 12 university hospitals. Ambulatory adults with overt osteoradionecrosis of the mandible were assigned to receive 30 HBO exposures preoperatively at 2.4 absolute atmosphere for 90 minutes or a placebo, and 10 additional HBO dives postoperatively or a placebo. The main outcome measure was 1-year recovery rate from osteoradionecrosis. Secondary end points included time to treatment failure, time to pain relief, 1-year mortality rate, and treatment safety. Results: At the time of the second interim analysis, based on the triangular test, the study was stopped for potentially worse outcomes in the HBO arm. A total of 68 patients were enrolled and analyzed. At 1 year, six (19%) of 31 patients had recovered in the HBO arm and 12 (32%) of 37 in the placebo arm (relative risk = 0.60; 95% CI, 0.25 to 1.41; P = .23). Time to treatment failure (hazard ratio = 1.33; 95% CI, 0.68 to 2.60; P = .41) and time to pain relief (hazard ratio = 1.00; 95% CI, 0.52 to 1.89; P = .99) were similar between the two treatment arms. Conclusion: Patients with overt mandibular osteoradionecrosis did not benefit from hyperbaric oxygenation.
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“The primary outcome measure was the 1‐year recovery rate from osteoradionecrosis, but the results showed that patients with pronounced osteoradionecrosis of the mandible did not benefit from HBO. 373”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [373]
Citations
Cites
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1 of the 22 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Hart GB, Strauss MB. Hyperbaric oxygen in the management of radiation injury, In Schmutz J (ed): Stiftüng für Hyperbaric Medizin. Basel, Proceedings 1st Swiss Symposium on Hyperbaric Medicine, pp 31,1986-51
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Hyperbaric Oxygen: Its Mechanisms and Efficacy
Thom, S. R. (2011) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181fbe2bf · Cited by 614
Radiation therapy‐associated toxicity: Etiology, management, and prevention
Wang, K., & Tepper, J. E. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21689 · Cited by 473
Hyperbaric oxygen therapy for late radiation tissue injury
Bennett, M. H., Feldmeier, J., Hampson, N. B., Smee, R., & Milross, C. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005005.pub4 · Cited by 368
Oral complications of radiotherapy
Sciubba, J. J., & Goldenberg, D. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70580-0 · Cited by 358
Treatment of late sequelae after radiotherapy for head and neck cancer
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Metadata
- Authors
- Annane, D., Depondt, J., Aubert, P., Villart, M., Géhanno, P., Gajdos, P., & Chevret, S.
- Affiliations
- Hôpital Raymond-Poincaré (FR)
- Venue
- Journal of Clinical Oncology
- Published
- 2004-12-15
- Volume
- 22
- Issue
- 24
- Pages
- 4893-4900
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2166297968
- Cited by
- 357
- References
- 22
- Citations by year
- 2026: 6 · 2025: 21 · 2024: 21 · 2023: 12 · 2022: 12 · 2021: 25 · 2020: 14 · 2019: 18 · 2018: 12 · 2017: 15 · 2016: 21 · 2015: 19 · 2014: 19 · 2013: 11 · 2012: 24
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › General Dentistry › Oral health in cancer treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- hyperbaric oxygen therapy, osteoradionecrosis of the jaw, mandible, radiotherapy complications, treatment failure, analgesia, treatment safety
- MeSH terms
- Double-Blind Method, Female, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Male, Mandibular Diseases, Middle Aged, Osteoradionecrosis, Placebos, Treatment Outcome
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