Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies

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1. Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
   Rouzbeh Daylami, Diego J. Muilenburg, Subbulakshmi Virudachalam, Richard J. Bold · 2014 · Journal of Experimental & Clinical Cancer Research
2. Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin
   Niramol Savaraj, Chunjing Wu, Yingying Li, Medhi Wangpaichitr, Min You, John S. Bomalaski, Wei He, Macus Tien Kuo, Lynn G. Feun · 2015 · Oncotarget
3. Unlocking the Potential of Arginine Deprivation Therapy: Recent Breakthroughs and Promising Future for Cancer Treatment
   Yu‐De Chu, Ming‐Wei Lai, Chau‐Ting Yeh · 2023 · International Journal of Molecular Sciences
4. Phase 1 trial of ADI-PEG20 plus cisplatin in patients with pretreated metastatic melanoma or other advanced solid malignancies
   Shuyang Yao, Filip Jankú, Vivek Subbiah, John Stewart, Sapna Pradyuman Patel, Ahmed Omar Kaseb, Shannon Neville Westin, Aung Naing, Apostolia Maria Tsimberidou, David S. Hong et al. · 2021 · British Journal of Cancer
5. Arginine deprivation as a new treatment strategy for head and neck cancer
   Cheng‐Chih Huang, Sen‐Tien Tsai, Ching‐Chuan Kuo, Jeffrey Shu-Ming Chang, Ying‐Tai Jin, Jang‐Yang Chang, Jenn‐Ren Hsiao · 2012 · Oral Oncology
6. Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression
   Stephanie S. Kim, Shili Xu, Jing Cui, Soumya Poddar, Thuc M. Le, Hovhannes Hayrapetyan, Luyi Li, Nanping Wu, Alexandra M. Moore, Lei Zhou et al. · 2019 · Theranostics
7. PEGylation and pharmacological characterization of a potential anti-tumor drug, an engineered arginine deiminase originated from Pseudomonas plecoglossicida
   Long Zhang, Meng‐Han Liu, Serwanja Jamil, Ruizhi Han, Guochao Xu, Ye Ni · 2014 · Cancer Letters
8. Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20)
   Natalie Burrows, Gaëlle Cane, Mathew P. Robson, Edoardo Gaude, William Howat, Peter Wojciech Szlosarek, R. Barbara Pedley, Christian Frezza, Margaret A. Ashcroft, Patrick Henry Maxwell · 2016 · Scientific Reports
9. Recombinant Human Arginase Toxicity in Mice Is Reduced by Citrulline Supplementation
   Jeremy Mauldin, Ideen Zeinali, Keri Kleypas, Jung Hee Woo, Rebecca S. Blackwood, Chan-Hee Jo, Everett M Stone, George Georgiou, Arthur Edward Frankel · 2012 · Translational Oncology
10. Attenuation of Argininosuccinate Lyase Inhibits Cancer Growth via Cyclin A2 and Nitric Oxide
    Hau-Lun Huang, Hui‐Ping Hsu, Shu-Chu Shieh, Yung-Sheng Chang, Wei-Ching Chen, Chien-Yu Cho, Chiao‐Fang Teng, Ih‐Jen Su, Wen-Chun Hung, Ming-Derg Lai · 2013 · Molecular Cancer Therapeutics
11. Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts
    Lucy E. Métayer, Richard D. Brown, Saskia Carlebur, G.A. Amos Burke, Guy Charles Brown · 2018 · APOPTOSIS
12. Argininosuccinate synthase 1, arginine deprivation therapy and cancer management
    Naihui Sun, Xing Zhao · 2022 · Frontiers in Pharmacology
13. Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer
    Peter Edward Hall, Neal Ready, Amanda L. Johnston, John S. Bomalaski, Ralph Rudolph Venhaus, Michael T. Sheaff, Lee M. Krug, Peter Wojciech Szlosarek · 2020 · Clinical Lung Cancer
14. Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
    Lisha Bao, Tong Xu, Xixuan Lu, Ping Cheong Huang, Zongfu Pan, Minghua Ge · 2021 · Frontiers in Oncology
15. Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1
    Giulia Agnello, Susan E. Alters, Scott W. Rowlinson · 2019 · Translational research
16. Bench-to-Bedside Studies of Arginine Deprivation in Cancer
    George Field, Iuliia Pavlyk, Peter Wojciech Szlosarek · 2023 · Molecules
17. Cancer cell sensitivity to arginine deprivation in vitro is not determined by endogenous levels of arginine metabolic enzymes
    Yaroslav P. Bobak, Bozhena Vynnytska‐Myronovska, Yuliya V. Kurlishchuk, Andriy А. Sibirny, Oleh V. Stasyk · 2010 · Cell Biology International
18. Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells
    Vaidehi Agrawal, Jung Hee Woo, Jeremy Mauldin, Chan‐Hee Jo, Everett M Stone, George Georgiou, Arthur Edward Frankel · 2011 · Anti-Cancer Drugs
19. L-Canavanine potentiates the cytotoxicity of doxorubicin and cisplatin in arginine deprived human cancer cells
    Agustina DR Nurcahyanti, Michaël Wink · 2016 · PeerJ
20. A Potential Antitumor Drug (Arginine Deiminase) Reengineered for Efficient Operation under Physiological Conditions
    Leilei Zhu, Rajni Verma, Danilo Roccatano, Ye Ni, Zhihao Sun, Ulrich Schwaneberg · 2010 · ChemBioChem
21. Increased expression of argininosuccinate synthetase protein predicts poor prognosis in human gastric cancer
    Yan‐Shen Shan, Hui‐Ping Hsu, Ming-Derg Lai, Meng‐Chi Yen, YI-PEY LUO, Yi‐Ling Chen · 2014 · Oncology Reports
22. Analysis of Gene Expression Identifies Differentially Expressed Genes and Pathways Associated with Lymphatic Dissemination in Patients with Adenocarcinoma of the Esophagus
    Sjoerd M. Lagarde, P. E. Ver Loren van Themaat, Perry D. Moerland, Lisa A. Gilhuijs-Pederson, Fiebo J.W. ten Kate, Pieter H. Reitsma, Antoine H. C. van Kampen, Aeilko Having Zwinderman, Frank Baas, J. Jan B. van Lanschot · 2008 · Annals of Surgical Oncology
23. Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase–Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase
    Divya Sahu, Sounak Gupta, Andrew M. Hau, Kazufumi Nakashima, Mariah Zampieri Leivo, Stephen C. Searles, Paul J. Elson, John S. Bomalaski, Darren E. Casteel, Gerry R. Boss et al. · 2016 · American Journal Of Pathology
24. The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma
    Angkana Thongkum, Chunjing Wu, Ying-Ying Li, Medhi Wangpaichitr, Panida Navasumrit, Varabhorn Parnlob, Thaniya Sricharunrat, Vajarabhongsa Bhudhisawasdi, Mathuros Ruchirawat, Niramol Savaraj · 2017 · International Journal of Molecular Sciences
25. Targeted Arginine Metabolism Therapy: A Dilemma in Glioma Treatment
    Xiaoshuang Hou, Sui Chen, Po Zhang, Dongsheng Guo, Baofeng Wang · 2022 · Frontiers in Oncology
26. The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma.
    Niramol Savaraj, Chunjing Wu, Marcus Tien Kuo, Min You, Medhi Wangpaichitr, Carlos Robles, Seth A. Spector, Lynn G. Feun · 2007 · Europe PMC (PubMed Central)
27. Arginine deiminase originating fromLactococcus lactisssp.lactisAmerican Type Culture Collection (ATCC) 7962 induces G1-phase cell-cycle arrest and apoptosis in SNU-1 stomach adenocarcinoma cells
    Jong‐Eun Kim, Seoyoung C. Kim, Ki Won Lee, Hyong Joo Lee · 2009 · British Journal Of Nutrition
28. Update on therapy for melanoma: opportunities for patient selection and overcoming tumor resistance
    Henry B. Koon, Michael B. Atkins · 2006 · Expert Review of Anticancer Therapy
29. Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment
    Neha Kumari, Saurabh Bansal · 2021 · Cancer Chemotherapy and Pharmacology
30. A Phase 1 study of ADI‐PEG20 (pegargiminase) combined with cisplatin and pemetrexed in ASS1‐negative metastatic uveal melanoma
    Pui Ying Chan, Melissa M. Phillips, Stephen M. Ellis, Amanda L. Johnston, Xiaoxing Feng, Amit Arora, Gordon R. Hay, Victoria M.L. Cohen, Mandeep S. Sagoo, John S. Bomalaski et al. · 2022 · Pigment Cell & Melanoma Research
31. Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells
    Ziyu Wang, Xunlong Shi, Yubin Li, Xian Liang Zeng, Jiajun Fan, Yun Sun, Zongshu Xian, Guoping Zhang, Shaofei Wang, Haifeng Hu et al. · 2013 · Applied Microbiology and Biotechnology
32. Targeting methionine auxotrophy in cancer: discovery & exploration
    Vaidehi Agrawal, Sarah EJ Alpini, Everett M Stone, Eugene P. Frenkel, Arthur Edward Frankel · 2011 · Expert Opinion on Biological Therapy
33. The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
    Niramol Savaraj, Chunjing Wu, Marcus Tien Kuo, Min You, Medhi Wangpaichitr, Carlos Robles, Seth A. Spector, Lynn G. Feun · 2007 · Drug Target Insights
34. The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines
    Min You, Niramol Savaraj, Medhi Wangpaichitr, Chunjing Wu, M. Tien Kuo, Javier Varona-Santos, Dao M. Nguyen, Lynn G. Feun · 2010 · Biochemical and Biophysical Research Communications
35. Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy
    Everett M Stone, Lynne Chantranupong, Candice Gonzalez, Jamye F. O’Neal, Mridula Rani, Carla L. Van Den Berg, George Georgiou · 2011 · Journal of Controlled Release
36. [HuArgI (co)-PEG5000]-induced arginine deprivation leads to autophagy dependent cell death in pancreatic cancer cells
    Nathalie Khalil, Ralph Joseph Abi‐Habib · 2019 · Investigational New Drugs
37. Phase 1 trial of ADI‐PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors
    Shuyang Yao, Filip Jankú, Kimberly B. Koenig, Apostolia Maria Tsimberidou, Sarina Anne Piha-Paul, Nai Shi, John Stewart, Amanda L. Johnston, John S. Bomalaski, Funda Meric‐Bernstam et al. · 2021 · Cancer Medicine
38. A Prognostic Model for Colon Adenocarcinoma Patients Based on Ten Amino Acid Metabolism Related Genes
    Yangzi Ren, Shangwen He, Siyang Feng, Wei Yang · 2022 · Frontiers in Public Health
39. Reprogramming of urea cycle in cancer: Mechanism, regulation and prospective therapeutic scopes
    Noyel Ghosh, Sushweta Mahalanobish, Parames Chandra Sil · 2024 · Biochemical Pharmacology
40. Novel systemic therapy against malignant pleural mesothelioma
    Michael R. Mancuso, Joel W. Neal · 2017 · Translational Lung Cancer Research
41. An Engineered Arginase FC Protein Inhibits Tumor GrowthIn VitroandIn Vivo
    Lihua Li, Yan Wang, Jun Chen, Bi Cheng, Jiehua Hu, Yuehua Zhou, Xin Gao, Liucun Gao, Xifan Mei, Meiyan Sun et al. · 2013 · Evidence-based Complementary and Alternative Medicine
42. Differential expression of argininosuccinate synthetase in serous and non‐serous ovarian carcinomas
    Dong‐Joo Cheon, Ann E. Walts, Jessica A. Beach, Jenny Lester, John S. Bomalaski, Christine Walsh, W. Ruprecht Wiedemeyer, Beth Y. Karlan, Sandra Oršulić · 2014 · The Journal of Pathology Clinical Research
43. Kinetic characterization of arginine deiminase and carbamate kinase from Streptococcus pyogenes M49
    Silvio Hering, Antje Sieg, Bernd Kreikemeyer, Tomas Fiedler · 2013 · Protein Expression and Purification
44. Protein Engineering of the Antitumor Enzyme PpADI for Improved Thermal Resistance
    Leilei Zhu, Feng Cheng, Victoria Piatkowski, Ulrich Schwaneberg · 2013 · ChemBioChem
45. Arginine Deiminase: Current Understanding and Applications
    Mahboubeh Zarei, Mohammad Reza Rahbar, Mohammad Hossein Morowvat, Navid Nezafat, Manica Negahdaripour, Aydin Berenjian, Younes Ghasemi · 2018 · Recent Patents on Biotechnology
46. Abnormal arginine metabolism is associated with prognosis in patients of gastric cancer
    Linyang Shi, Yuanyuan Wang, Yu Jing, Minghao Xu, Zhi‐Tu Zhu, Qingjun Wang · 2021 · Translational Cancer Research
47. Novel Mechanistic Insights into Arginine Deiminase Pharmacology Suggest 18F-FDG Is Not Suitable to Evaluate Clinical Response in Melanoma
    Lars Stelter, Michael J. Evans, Achim A. Jungbluth, PAT B. ZANZONICO, Gerd Ritter, Thomas W. Ku, Eric Rosenfeld, John S. Bomalaski, Lloyd J. Old, Steven M. Larson · 2012 · Journal of Nuclear Medicine
48. Arginine starvation in colorectal carcinoma cells: Sensing, impact on translation control and cell cycle distribution
    Bozhena Vynnytska‐Myronovska, Yuliya V. Kurlishchuk, Oleg Chen, Yaroslav P. Bobak, Claudia Dittfeld, Melanie Hüther, Leoni A. Kunz‐Schughart, Oleh V. Stasyk · 2016 · Experimental Cell Research
49. Three-dimensional environment renders cancer cells profoundly less susceptible to a single amino acid starvation
    Bozhena Vynnytska‐Myronovska, Yuliya V. Kurlishchuk, Yaroslav P. Bobak, Claudia Dittfeld, Leoni A. Kunz‐Schughart, Oleh V. Stasyk · 2013 · Amino Acids
50. A bioengineered arginine-depleting enzyme as a long-lasting therapeutic agent against cancer
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51. Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy
    Joséphine Carpentier, Iuliia Pavlyk, Uma Mukherjee, Peter Edward Hall, Peter Wojciech Szlosarek · 2022 · Lung Cancer Targets and Therapy
52. Enhancing Leukemia Treatment: The Role of Combined Therapies Based on Amino Acid Starvation
    Can Chen, Ji Zhang · 2024 · Cancers
53. NRF3 activates mTORC1 arginine-dependently for cancer cell viability
    Hirose, Shuuhei, Waku, Tsuyoshi, Tani, Misato, Masuda, Haruka, Endo, Keiko, Ashitani, Sanae, Aketa, Iori, Kitano, Hina, Nakada, Sota, Wada, Ayaka et al. · 2023 · iScience
54. Argininosuccinate Synthetase-1 (ASS1) Loss in High-Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20
    Sounak Gupta, Divya Sahu, John S. Bomalaski, Igor Frank, Stephen Anthony Boorjian, Prabin Bikram Thapa, John C. Cheville, Donna Elizabeth Hansel · 2018 · Endocrine Pathology
55. A metabolic perspective on nitric oxide function in melanoma
    John Jimenez, Parul Dubey, Bethany Carter, John M. Koomen, Joseph Markowitz · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
56. Imaging of tumor vascularization using fluorescence molecular tomography to monitor arginine deiminase treatment in melanoma.
    Lars Stelter, Michael J. Evans, Achim A. Jungbluth, Valerie A. Longo, PAT B. ZANZONICO, Gerd Ritter, John S. Bomalaski, Lloyd J. Old, Steven M. Larson · 2013 · PubMed
57. Amino Acid Uptake Measured by [18F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas
    Bethany Cheree Prudner, Fangdi Sun, Jeff C. Kremer, Jinbin Xu, Chaofeng Huang, Kiran Kumar Solingapuram Sai, Zachary Morgan, Hayden Leeds, Jonathan McConathy, Brian Andrew Van Tine · 2018 · Theranostics
58. Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability
    Yuliya V. Kurlishchuk, Bozhena Vynnytska‐Myronovska, Philipp Grosse‐Gehling, Yaroslav P. Bobak, Friederike Manig, Oleg Chen, Sebastian R. Merker, Thomas Henle, Steffen Löck, Daniel E. Stange et al. · 2016 · Oncotarget
59. Arginine deprivation as a treatment approach targeting cancer cell metabolism and survival: A review of the literature
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60. Peptide and Protein Bioconjugation
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61. Evaluation of Arginine Deiminase Treatment in Melanoma Xenografts Using 18F-FLT PET
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62. Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models
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63. Enhancing the Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Signaling and Arginine Deprivation in Melanoma
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64. Argininosuccinate synthetase (ASS) deficiency in high-grade pulmonary neuroendocrine carcinoma: an opportunity for personalized targeted therapy
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65. Arginine enzymatic deprivation and diet restriction for cancer treatment
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66. The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge
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67. Reduced expression of ASS is closely related to clinicopathological features and post-resectional survival of hepatocellular carcinoma
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68. Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy
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69. In-silico studies to recognize repurposing therapeutics toward arginase-I inhibitors as a potential onco-immunomodulators
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70. The emerging roles of the urea cycle in tumor microenvironment and therapies
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71. Genetics and Molecular Biology of Mesothelioma
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72. RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells
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73. Indospicine combined with arginine deprivation triggers cancer cell death via caspase‐dependent apoptosis
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74. Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis
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75. Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy
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76. Arginase: Mechanisms and Clinical Application in Hematologic Malignancy
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77. The exploitation of enzyme-based cancer immunotherapy
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78. Nitric oxide donor augments antineoplastic effects of arginine deprivation in human melanoma cells
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79. Immobilization of engineered arginase on gold-carbon nanotubes
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80. The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C
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81. Cancer therapies based on enzymatic amino acid depletion
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82. Exploring Metabolic Approaches for Epithelial Ovarian Cancer Therapy
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83. Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo
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84. Therapeutic interventions to disrupt the protein synthetic machinery in melanoma
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85. Parallel Expression of Enzyme Inhibitors of CD8T Cell Activity in Tumor Microenvironments and Secretory Endometrium
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86. Guanidine-Modifying Enzymes in the Pentein Superfamily
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87. Colorectal cancer cell-derived exosomes induce metabolic reprogramming of cancer-associated fibroblasts to promote colorectal cancer growth
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88. PEG: a useful technology in anticancer therapy
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89. Reduced Expression of Argininosuccinate Lyase is Closely Associated With Postresectional Survival in Hepatocellular Carcinoma
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90. Poly(ethylene glycol)-Protein, Peptide, and Enzyme Conjugates
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91. Microbial-Based Therapy of Cancer
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92. Combination of Arginine Depletion and Chemotherapy in Thoracic Malignancies
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93. Tumor starvation by L-arginine deprivation
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94. Development of Cultivation Technology for the Escherichia coli Recombinant Strain Producing Arginine Deiminase of Mycoplasma hominis
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95. The differential regulation of the urea cycle in tumors goes awry
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96. Recent Advances in Drug Development Targeting Cancer Metabolism
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97. In-vivo evaluation of human recombinant Co-arginase against A375 melanoma xenografts
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98. Enzymes in oncohematology: relevant directions of experimental studies and prospects of clinical use
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99. The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
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100. l-Arginine-Incorporated Albumin Mesospheres: A Drug Delivery System for Cancer Therapy
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