The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Randomized Trial of Hyperthermia and Radiation for Superficial Tumors
Abstract
Purpose: Randomized clinical trials have demonstrated hyperthermia (HT) enhances radiation response. These trials, however, generally lacked rigorous thermal dose prescription and administration. We report the final results of a prospective randomized trial of superficial tumors (≤ 3 cm depth) comparing radiotherapy versus HT combined with radiotherapy, using the parameter describing the number of cumulative equivalent minutes at 43°C exceeded by 90% of monitored points within the tumor (CEM 43°C T 90) as a measure of thermal dose. Methods: This trial was designed to test whether a thermal dose of more than 10 CEM 43°C T 90 results in improved complete response and duration of local control compared with a thermal dose of ≤ 1 CEM 43°C T 90. Patients received a test dose of HT ≤ 1 CEM 43°C T 90 and tumors deemed heatable were randomly assigned to additional HT versus no additional HT. HT was given using microwave spiral strip applicators operating at 433 MHz. Results: One hundred twenty-two patients were enrolled; 109 (89%) were deemed heatable and were randomly assigned. The complete response rate was 66.1% in the HT arm and 42.3% in the no-HT arm. The odds ratio for complete response was 2.7 (95% CI, 1.2 to 5.8; P = .02). Previously irradiated patients had the greatest incremental gain in complete response: 23.5% in the no-HT arm versus 68.2% in the HT arm. No overall survival benefit was seen. Conclusion: Adjuvant hyperthermia with a thermal dose more than 10 CEM 43°C T 90 confers a significant local control benefit in patients with superficial tumors receiving radiation therapy.
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“complete response: 24%–31% in the no-hyperthermia arm versus 57%–68% in the hyperthermia arm) [72, 73].”
BackgroundJohannsen, M., Gneveckow, U., Thiesen, B., Taymoorian, K., Cho, C. H., Waldöfner, N., Scholz, R., Jordan, A., Loening, S. A., & Wust, P. (2007) · European Urology · doi:10.1016/j.eururo.2006.11.023 · Cited by 532
Metadata
- Authors
- Jones, E. L., Oleson, J. R., Prosnitz, L. R., Samulski, T. V., Vujaskovic, Z., Yu, D., Sanders, L. L., & Dewhirst, M. W.
- Venue
- Journal of Clinical Oncology
- Published
- 2005-05-01
- Volume
- 23
- Issue
- 13
- Pages
- 3079-3085
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2016204586
- Cited by
- 560
- References
- 16
- FWCI
- 16.86
- Type
- journal article
- Language
- en
- Open access
- closed
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