The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Colorectal Cancer Prevention
Abstract
Colorectal cancer is the second leading cause of mortality in the United States. In the United States, the cumulative lifetime risk of developing colorectal cancer for both men and women is 6%. Despite advances in the management of this disease, the 5-year survival rate in the United States in only 62%. Because only 38% of patients are diagnosed when the cancers are localized to the bowel wall, it is likely that widespread implementation of screening could significantly improve the outcome. Colorectal cancer screening is cost effective, irrespective of the methods used. In addition to currently available methods (fecal occult blood, flexible sigmoidoscopy, colonoscopy, and double contrast barium enema), computed tomographic colonography (virtual colonoscopy) and stool-based molecular screening are under development. Four classes of chemopreventive compounds have demonstrated efficacy in reducing recurrent colorectal adenomas and/or cancer in randomized, controlled trials. They are selenium, calcium carbonate, hormone replacement therapy, and nonsteroidal anti-inflammatory drugs. The mechanisms of action of nonsteroidal anti-inflammatory drugs include inhibition of the cyclooxygenase system as well as cyclooxygenase-independent effects. Considerable effort is being expended to define chemopreventive activity, optimal dose, administration schedule, and toxicity for the coxibs in adenoma recurrence prevention trials. The threshold for tolerating toxicities is very low in asymptomatic individuals at minimally increased risk for colorectal neoplasia.
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Cites
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A genetic model for colorectal tumorigenesis
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Genetic Alterations during Colorectal-Tumor Development
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Prevention of Colorectal Cancer by Colonoscopic Polypectomy
Winawer, S. J., Zauber, A. G., Ho, M. N., O'Brien, M. J., Gottlieb, L. S., Sternberg, S. S., Waye, J. D., Schapiro, M., Bond, J. H., Panish, J. F., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292701 · Cited by 4,592
Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood
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Randomised controlled trial of faecal-occult-blood screening for colorectal cancer
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Cited by
Kamangar, F., Dores, G. M., & Anderson, W. F. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.2308 · Cited by 3,434
Molecular Genetics of Colorectal Cancer
Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805
Celecoxib for the Prevention of Sporadic Colorectal Adenomas
Bertagnolli, M. M., Eagle, C. J., Zauber, A. G., Redston, M., Solomon, S. D., Kim, K., Tang, J., Rosenstein, R. B., Wittes, J., Corle, D., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061355 · Cited by 1,048
Self-citationIdentifying viruses from metagenomic data using deep learning
Ren, J., Song, K., Deng, C., Ahlgren, N. A., Fuhrman, J. A., Li, Y., Xie, X., Poplin, R., & Sun, F. (2020) · Quantitative Biology · doi:10.1007/s40484-019-0187-4 · Cited by 659
Beydoun, H. A., & Beydoun, M. A. (2008) · Cancer Causes & Control · doi:10.1007/s10552-007-9100-y · Cited by 329
Metadata
- Authors
- Hawk, E. T., & Levin, B.
- Venue
- Journal of Clinical Oncology
- Published
- 2005-01-10
- Volume
- 23
- Issue
- 2
- Pages
- 378-391
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1977516311
- Cited by
- 278
- References
- 131
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hawk, E. T., & Levin, B. (2005). Colorectal Cancer Prevention. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2005.08.097
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
