The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Predictors of Survival After Radiofrequency Thermal Ablation of Colorectal Cancer Metastases to the Liver: A Prospective Study
Open accessAbstract
Purpose: The aim of this study was to determine the predictors of survival at the time of radiofrequency thermal ablation (RFA) in patients with colorectal liver metastasis. Patients and Methods: One hundred thirty-five patients with colorectal liver metastases who were not candidates for resection underwent laparoscopic RFA. Results: The median Kaplan-Meier survival for all patients was 28.9 months after RFA treatment. Patients with a carcinoembryonic antigen (CEA) less than 200 ng/mL had improved survival compared with those with a CEA more than 200 (34 v 16 months; P = .01). Patients with the dominant lesion less than 3 cm in diameter had a median survival of 38 v 34 months for lesions 3 to 5 cm, and 21 months for lesions greater than 5 cm (P = .03). Survival approached significance for patients with one to three tumors versus more than three tumors (29 v 22 months; P = .09). The presence of extrahepatic disease did not affect survival. Only the largest liver tumor size more than 5 cm was found to be a significant predictor of mortality by Cox proportional hazards model, with a 2.5-fold increased risk of death versus the largest liver tumor size less than 3 cm (P = .05). Conclusion: This study determines which patients do best after RFA. Historical survival with chemotherapy alone is 11 to 14 months, suggesting RFA has a positive impact on overall survival. Limited amounts of extrahepatic disease do not appear to affect survival adversely. RFA is a useful adjunct to chemotherapy in those patients with liver-predominant disease.
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Cited by
Pulmonary Radiofrequency Ablation: Long-term Safety and Efficacy in 153 Patients
Simon, C. J., Dupuy, D. E., DiPetrillo, T. A., Safran, H. P., Grieco, C. A., Ng, T., & Mayo-Smith, W. W. (2007) · Radiology · doi:10.1148/radiol.2431060088 · Cited by 557
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Labianca, R., Beretta, G. D., Kildani, B., Milesi, L., Merlin, F., Mosconi, S., Pessi, M. A., Prochilo, T., Quadri, A., Gatta, G., et al. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.01.010 · Cited by 409
Dose-Escalation Study of Single-Fraction Stereotactic Body Radiotherapy for Liver Malignancies
Goodman, K. A., Wiegner, E. A., Maturen, K. E., Zhang, Z., Mo, Q., Yang, G., Gibbs, I. C., Fisher, G. A., & Koong, A. C. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.08.020 · Cited by 323
Metadata
- Authors
- Berber, E., Pelley, R., & Siperstein, A. E.
- Venue
- Journal of Clinical Oncology
- Published
- 2005-03-01
- Volume
- 23
- Issue
- 7
- Pages
- 1358-1364
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2121576843
- Cited by
- 264
- References
- 11
- FWCI
- 18.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Berber, E., Pelley, R., & Siperstein, A. E. (2005). Predictors of Survival After Radiofrequency Thermal Ablation of Colorectal Cancer Metastases to the Liver: A Prospective Study. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2005.12.039
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