Cited by 214Pancreatic and Hepatic Oncology ResearchCancer Genomics and DiagnosticsPancreatitis Pathology and Treatment

The DOI matches its Crossref record; 114 of the 116 references it cites were found in a registry or an index.

Molecular Markers of Early Pancreatic Cancer

Goggins, Michael·2005·Journal of Clinical Oncology

DOI 10.1200/jco.2005.19.711

Open this paper in CoChat — free account

Abstract

Pancreatic cancer is a deadly disease and the fourth most common cause of cancer death in the United States. Since chemotherapy and radiotherapy have thus far largely failed to significantly improve the survival of patients with pancreatic ductal adenocarcinoma, there is considerable interest in identifying better diagnostic markers of pancreatic neoplasia. Not only could better markers improve the early diagnosis of pancreatic cancer and allow more patients to undergo curative surgical resection, but also could potentially be used for patients at high risk of developing pancreatic cancer to identify precancerous lesions while they are amenable to cure. A wealth of information has recently become available about gene expression, DNA methylation, and proteomics alterations that occur in pancreatic cancers creating hope that better diagnostic markers of pancreatic cancer will be soon forthcoming.

Integrity signals

Registry

Crossref · 10.1200/jco.2005.19.711

Cites

114 of 114 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Cancer Statistics, 2005
Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R. C., Ghafoor, A., Feuer, E. J., & Thun, M. J. (2005) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.1.10 · Cited by 4,186
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753
Phases of Biomarker Development for Early Detection of Cancer
Pepe, M. S., Etzioni, R., Feng, Z., Potter, J. D., Thompson, M. L., Thornquist, M., Winget, M., & Yasui, Y. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.14.1054 · Cited by 1,686
Colorectal carcinoma antigens detected by hybridoma antibodies
Koprowski, H., Steplewski, Z., Mitchell, K. F., Herlyn, M., Herlyn, D., & Fuhrer, P. (1979) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01542654 · Cited by 1,360
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M. E. M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., & Kern, S. E. (1994) · Nature Genetics · doi:10.1038/ng0994-27 · Cited by 1,132
An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms
Hruban, R. H., Takaori, K., Klimstra, D. S., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Biankin, S. A., Compton, C., Fukushima, N., Furukawa, T., et al. (2004) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000126675.59108.80 · Cited by 1,091
Self-citation
Hereditary Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., DiMagno, E. P., Elitsur, Y., Gates, L. K., Perrault, J., Whitcomb, D. C., & International Hereditary Pancreatitis Study Group (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.6.442 · Cited by 988
Pancreaticoduodenectomy for Cancer of the Head of the Pancreas 201 Patients
Yeo, C. J., Cameron, J. L., Lillemoe, K. D., Sitzmann, J. V., Hruban, R. H., Goodman, S. N., Dooley, W. C., Coleman, J., & Pitt, H. A. (1995) · Annals of Surgery · doi:10.1097/00000658-199506000-00011 · Cited by 945

Show all 116 references

Research works printed but not linked: 4

10.1023/A:1008386130283 · DOI
10.1016/S0889-8588(01)00007-7 · DOI
10.7326/0003-4819-131-4-199908170-00003 · DOI · Paper page
10.4161/cbt.206 · DOI

Sorted by citations

Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer
Tan, B. H. L., Birdsell, L., Martin, L., Baracos, V. E., & Fearon, K. C. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1525 · Cited by 656
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
Gironella, M., Seux, M., Xie, M.-J., Cano, C. E., Tomasini, R., Gommeaux, J., Garcia, S., Nowak, J., Yeung, M. L., Jeang, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703942104 · Cited by 548
Early detection of pancreatic cancer
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., Li, D., Greenhalf, W., Jeon, C. Y., Koay, E. J., et al. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30416-9 · Cited by 482
Glycans as cancer biomarkers
Adamczyk, B., Tharmalingam, T., & Rudd, P. M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.12.001 · Cited by 481
Biological functions of fucose in mammals
Schneider, M., Al-Shareffi, E., & Haltiwanger, R. S. (2017) · Glycobiology · doi:10.1093/glycob/cwx034 · Cited by 432
Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report
Duffy, M. J., Sturgeon, C. M., Lamerz, R., Haglund, C. H., Holubec, V. L., Klapdor, R., Nicolini, A., Topolčan, O., & Heinemann, V. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp332 · Cited by 382
Pancreatic cancer: why is it so hard to treat?
Oberstein, P. E., & Olive, K. P. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13478680 · Cited by 334
Mucins in pancreatic cancer and its microenvironment
Kaur, S., Sushil Kumar, K., Momi, N., Sasson, A. R., & Batra, S. K. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.120 · Cited by 302
Molecular genetics of pancreatic intraepithelial neoplasia
Feldmann, G., Beaty, R., Hruban, R. H., & Maitra, A. (2007) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-006-1166-5 · Cited by 269
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma
Kelly, K. A., Bardeesy, N. M., Anbazhagan, R., Gurumurthy, S., Berger, J. H., Alencar, H., DePinho, R. A., Mahmood, U., & Weissleder, R. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050085 · Cited by 242
Early Diagnosis of Pancreatic Cancer: Challenges and New Developments
Kaur, S., Baine, M. J., Jain, M., Sasson, A. R., & Batra, S. K. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.69 · Cited by 221
DNA Methylation Alterations in the Pancreatic Juice of Patients with Suspected Pancreatic Disease
Matsubayashi, H., Canto, M. I., Sato, N., Klein, A. P., Abe, T., Yamashita, K., Yeo, C. J., Kalloo, A. N., Hruban, R. H., & Goggins, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2664 · Cited by 213
Self-citation
Serum Markers in Patients with Resectable Pancreatic Adenocarcinoma: Macrophage Inhibitory Cytokine 1 versus CA19-9
Koopmann, J., Rosenzweig, C. N., Zhang, Z., Canto, M. I., Brown, D. A., Hunter, M. I., Yeo, C. J., Chan, D. W., Breit, S. N., & Goggins, M. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0564 · Cited by 212
Self-citation
Is mda-7/IL-24 a “Magic Bullet” for Cancer?
Fisher, P. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3127 · Cited by 201
Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer
Yi, J. M., Guzzetta, A. A., Bailey, V. J., Downing, S. R., Neste, L. V., Chiappinelli, K. B., Keeley, B. P., Stark, A., Herrera, A., Wolfgang, C. L., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3224 · Cited by 188
Self-citation
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts
Bhagat, T. D., Ahrens, D. V., Dawlaty, M. M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., et al. (2019) · eLife · doi:10.7554/elife.50663 · Cited by 178
Self-citation
Prognostic and Therapeutic Significance of Carbohydrate Antigen 19-9 as Tumor Marker in Patients with Pancreatic Cancer
Boeck, S. H., Stieber, P., Holdenrieder, S., Wilkowski, R., & Heinemann, V. (2006) · Oncology · doi:10.1159/000094888 · Cited by 172
A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study
Kaur, S., Smith, L. M., Patel, A., Menning, M., Watley, D. C., Malik, S. S., Krishn, S. R., Mallya, K. B., Aithal, A., Sasson, A. R., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.482 · Cited by 157
Differential and Epigenetic Gene Expression Profiling Identifies Frequent Disruption of the RELN Pathway in Pancreatic Cancers
Sato, N., Fukushima, N., Chang, R., Matsubayashi, H., & Goggins, M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.008 · Cited by 154
Self-citation
Glycosylation of liver acute‐phase proteins in pancreatic cancer and chronic pancreatitis
Sarrats, A., Saldova, R., Pla, E., Fort, E., Harvey, D. J., Struwe, W. B., Llorens, R., Rudd, P. M., & Peracaula, R. (2010) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900150 · Cited by 134
Biomarkers for early detection of breast cancer: What, when, and where?
LEVENSON, V (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.01.017 · Cited by 131
Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: a meta-analysis
Huang, Z., & Liu, F. (2014) · Tumor Biology · doi:10.1007/s13277-014-1995-9 · Cited by 130
Differential methylation of cell‐free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis
Liggett, T., Melnikov, A. A., Yi, Q., Replogle, C., Brand, R. E., Kaul, K. L., Talamonti, M. S., Abrams, R. A., & Levenson, V. (2010) · Cancer · doi:10.1002/cncr.24893 · Cited by 130
Therapeutic options for the management of pancreatic cancer
Rossi, M. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11142 · Cited by 130
Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E‐cadherin
Johnson, S., Ramani, V. C., Hennings, L. J., & Haun, R. S. (2007) · Cancer · doi:10.1002/cncr.22606 · Cited by 128
Novel Diagnostic and Predictive Biomarkers in Pancreatic Adenocarcinoma
Chang, J. C. S., & Kundranda, M. N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030667 · Cited by 127
Transcriptional Profiling of Peripheral Blood Mononuclear Cells in Pancreatic Cancer Patients Identifies Novel Genes with Potential Diagnostic Utility
Baine, M. J., Chakraborty, S., Smith, L. M., Mallya, K. B., Sasson, A. R., Brand, R. E., & Batra, S. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017014 · Cited by 122
Protein Alterations Associated with Pancreatic Cancer and Chronic Pancreatitis Found in Human Plasma using Global Quantitative Proteomics Profiling
Pan, S., Chen, R., Crispin, D. A., May, D., Stevens, T., McIntosh, M. W., Bronner, M. P., Ziogas, A., Anton‐Culver, H., & Brentnall, T. A. (2011) · Journal of Proteome Research · doi:10.1021/pr101148r · Cited by 118
Preoperative CEA and CA 19-9 are prognostic markers for survival after curative resection for ductal adenocarcinoma of the pancreas – A retrospective tumor marker prognostic study
Distler, M., Pilarsky, E., Kersting, S., & Grützmann, R. (2013) · International Journal of Surgery · doi:10.1016/j.ijsu.2013.10.005 · Cited by 117
Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
Haque, I., Mehta, S., Majumder, M., Dhar, K., De, A., McGregor, D., Van Veldhuizen, P. J., Banerjee, S. K., & Banerjee, S. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-8 · Cited by 113
Long-Term Outcome of High-Intensity Focused Ultrasound in Advanced Pancreatic Cancer
Sung, H. Y., Jung, S. E., Cho, S. H., Zhou, K., Han, J., Han, S. T., Kim, J. I., Kim, J. K., Choi, J. Y., Yoon, S. K., et al. (2011) · Pancreas · doi:10.1097/mpa.0b013e31821fde24 · Cited by 107
Serum Fatty Acid Synthase as a Marker of Pancreatic Neoplasia
Kim, W., Hong, S., Nyhan, S. M., Canto, M. I., Fedarko, N. S., Klein, A. P., Griffith, M., Omura, N., Medghalchi, S. M., Kuhajda, F., et al. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0144 · Cited by 103
Self-citation
Protein Profiling of Microdissected Pancreas Carcinoma and Identification of HSP27 as a Potential Serum Marker
Melle, C., Ernst, G., Escher, N., Hartmann, D., Schimmel, B., Bleul, A., Thieme, H., Kaufmann, R., Felix, K., Frieß, H., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.079194 · Cited by 97
K-ras Mutation and p16 and Preproenkephalin Promoter Hypermethylation in Plasma DNA of Pancreatic Cancer Patients
Jiao, L., Zhu, J., Hassan, M. M., Evans, D. B., Abbruzzese, J. L., & Li, D. (2006) · Pancreas · doi:10.1097/01.mpa.0000246665.68869.d4 · Cited by 96
Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer
Jimeno, A., & Hidalgo, M. M. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0005 · Cited by 92
Identification of a novel serum biomarker for pancreatic cancer, C4b-binding protein α-chain (C4BPA) by quantitative proteomic analysis using tandem mass tags
Sogawa, K., Takano, S., Iida, F., Satoh, M., Tsuchida, S., Kawashima, Y., Yoshitomi, H., Sanda, A., Kodera, Y., Takizawa, H., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.295 · Cited by 90
Single Extracellular VEsicle Nanoscopy
Saftics, A., Abuelreich, S., Romano, E., Ghaeli, I., Jiang, N., Spanos, M., Lennon, K. M., Singh, G. P., Das, S., Keuren‐Jensen, K. R. V., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12346 · Cited by 89
Role of endoscopic ultrasound in the diagnosis and staging of pancreatic cancer
Săftoiu, A., & Vilmann, P. (2008) · Journal of Clinical Ultrasound · doi:10.1002/jcu.20534 · Cited by 88
Circulating Tumor Cells in Pancreatic Cancer: Current Perspectives
Martini, V., Timme‐Bronsert, S., Fichtner‐Feigl, S., Hoeppner, J., & Kulemann, B. (2019) · Cancers · doi:10.3390/cancers11111659 · Cited by 83
Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies
Roy, R., Zurakowski, D., Wischhusen, J., Frauenhoffer, C., Hooshmand, S. M., Kulke, M. H., & Moses, M. A. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.462 · Cited by 82
Combined Serum CA19-9 and miR-27a-3p in Peripheral Blood Mononuclear Cells to Diagnose Pancreatic Cancer
Wang, W., Liu, L., Li, G., Chen, Y., Li, C., Jin, D., & Wang, X. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0307 · Cited by 84
Autoantibody Signature in Human Ductal Pancreatic Adenocarcinoma
Tomaino, B., Cappello, P., Capello, M., Fredolini, C., Ponzetto, A., Novarino, A., Ciuffreda, L., Bertetto, O., Angelis, C. D., Gaia, E., et al. (2007) · Journal of Proteome Research · doi:10.1021/pr070281a · Cited by 81
CA19-9 and CA242 as tumor markers for the diagnosis of pancreatic cancer: a meta-analysis
Gui, J., Yan, W., & Liu, X. (2013) · Clinical and Experimental Medicine · doi:10.1007/s10238-013-0234-9 · Cited by 81
Methylation profile of circulating plasma DNA in patients with pancreatic cancer
Melnikov, A. A., Scholtens, D. M., Talamonti, M., Bentrem, D. J., & Levenson, V. (2008) · Journal of Surgical Oncology · doi:10.1002/jso.21208 · Cited by 80
Survival and Prognostic Factors of Unresectable Pancreatic Cancer
Park, J. K., Yoon, Y. B., Kim, Y., Ryu, J. K., Yoon, W. J., & Lee, S. H. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000225657.30803.9d · Cited by 79
Circulating biomarkers for early diagnosis of pancreatic cancer: facts and hopes.
Zhang, X., Shi, S., Zhang, B., Ni, Q., Yu, X., & Xu, J. (2018) · PubMed Central · Cited by 78
Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancer
McCarroll, J. A., Teo, J., Boyer, C. A., Goldstein, D., Kavallaris, M., & Phillips, P. A. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00002 · Cited by 77
The Use of Biomarkers in Early Diagnostics of Pancreatic Cancer
Kunovský, L., Tesaříková, P., Kala, Z., Kroupa, R., Kysela, P., Dolina, J., & Trna, J. (2018) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2018/5389820 · Cited by 81
Epithelial-Mesenchymal Transition Markers in Pancreatic Ductal Adenocarcinoma
Cates, J., Byrd, R. H., Fohn, L. E., Tatsas, A. D., Washington, M. K., & Black, C. C. (2008) · Pancreas · doi:10.1097/mpa.0b013e3181878b7f · Cited by 76
Profile of exhaled-breath volatile organic compounds to diagnose pancreatic cancer
Markar, S. R., Brodie, B. C., Chin, S.-T., Romano, A., Spalding, D. R. C., & Hanna, G. B. (2018) · British journal of surgery · doi:10.1002/bjs.10909 · Cited by 74
NF-κB, inflammation and pancreatic carcinogenesis: NF-κB as a chemoprevention target (Review)
Zhang, Z., & Rigas, B. (2006) · International Journal of Oncology · doi:10.3892/ijo.29.1.185 · Cited by 73
DNA Methylation Alterations In Endoscopic Retrograde Cholangiopancreatography Brush Samples of Patients With Suspected Pancreaticobiliary Disease
Parsi, M. A., Li, A., Li, C., & Goggins, M. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.07.007 · Cited by 71
Self-citation
Adiponectin as a Potential Differential Marker to Distinguish Pancreatic Cancer and Chronic Pancreatitis
Chang, M., Chang, Y., Su, T., Yang, W., Chen, C., Tien, Y., Liang, P., Wei, S., & Wong, J. (2007) · Pancreas · doi:10.1097/mpa.0b013e3180547709 · Cited by 69
Circulating tumor cells in the diagnosis and management of pancreatic cancer
Cen, P., Ni, X., Yang, J., Graham, D. Y., & Li, M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.05.007 · Cited by 65
Current Approaches to Pancreatic Cancer Screening
Chhoda, A., Lu, L., Clerkin, B. M., Risch, H. A., & Farrell, J. J. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.09.013 · Cited by 64
Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma
Klett, H., Füllgraf, H., Levit‐Zerdoun, E., Hussung, S., Kowar, S., Küsters, S., Bronsert, P., Werner, M., Wittel, U. A., Fritsch, R., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00108 · Cited by 62
Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis
Chang, S. T., Zahn, J. M., Horecka, J., Kunz, P. L., Ford, J. M., Fisher, G. A., Le, Q., Chang, D. T., Ji, H. P., & Koong, A. C. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-105 · Cited by 61
Molecular markers of pancreatic cancer: development and clinical relevance
Fry, L. C., Mönkemüller, K. E., & Malfertheiner, P. (2008) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-007-0276-0 · Cited by 59
Proteomics analysis of bodily fluids in pancreatic cancer
Pan, S., Brentnall, T. A., & Chen, R. (2015) · PROTEOMICS · doi:10.1002/pmic.201400476 · Cited by 58
Current Strategies and Future Perspectives for Precision Medicine in Pancreatic Cancer
Regel, I., Mayerle, J. V., & Mukund, M. U. (2020) · Cancers · doi:10.3390/cancers12041024 · Cited by 61
The Role of Quantitative NPTX2 Hypermethylation as a Novel Serum Diagnostic Marker in Pancreatic Cancer
Park, J. K., Ryu, J. K., Yoon, W. J., Lee, S. H., Lee, G. Y., Jeong, K.-S., Kim, Y., & Yoon, Y. B. (2011) · Pancreas · doi:10.1097/mpa.0b013e318221c903 · Cited by 55
Serum DJ‐1 as a diagnostic marker and prognostic factor for pancreatic cancer
He, X., Liu, B., Yao, W. Y., Xiao Jiao, Z. H. A. O., Zheng, Z., Li, J. F., Bei Qin, Y. U., & Yao Zong, Y. U. A. N. (2011) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2011.00488.x · Cited by 54
Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma
Sharma, G. G., Okada, Y., Hoff, D. D. V., & Goel, A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.10.001 · Cited by 54
Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head.
Liao, Q., Zhao, Y.-P., Yang, Y., Li, L., Long, X. R., & Han, S. (2007) · PubMed · Cited by 53
Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs
Rogers, C. D., Fukushima, N., Sato, N., Shi, C., Prasad, N. B., Hustinx, S. R., Matsubayashi, H., Canto, M. I., Eshleman, J. R., Hruban, R. H., et al. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.10.3323 · Cited by 53
Self-citation
Application of a Global Proteomic Approach to Archival Precursor Lesions: Deleted in Malignant Brain Tumors 1 and Tissue Transglutaminase 2 Are Upregulated in Pancreatic Cancer Precursors
Cheung, W. L., Darfler, M. M., Alvarez, H., Hood, B. L., Conrads, T. P., Habbe, N., Krizman, D. B., Mollenhauer, J., Feldmann, G., & Maitra, A. (2008) · Pancreatology · doi:10.1159/000161012 · Cited by 52
Early Diagnosis of Pancreatic Ductal Adenocarcinoma by Combining Relative Expression Orderings With Machine-Learning Method
Zhang, Z., Wang, J.-S., Zulfiqar, H., Lv, H., Dao, F., & Lin, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.582864 · Cited by 52
Comparison of Serum Tumor Associated Material (TAM) with Conventional Biomarkers in Cancer Patients
Shu, J. H., Li, C.-G., Liu, Y., Yan, X.-C., Xu, X., Huang, X., Cao, J., Li, Y., Lu, Y.-Y., Wu, X., et al. (2012) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2012.13.5.2399 · Cited by 51
Reduced Plasma Level of CXC Chemokine Ligand 7 in Patients with Pancreatic Cancer
Matsubara, J., Honda, K., Ono, M., Tanaka, Y., Kobayashi, M., Jung, G., Yanagisawa, K., Sakuma, T., Nakamori, S., Sata, N., et al. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0397 · Cited by 51
Curing pancreatic cancer
Traub, B., Link, K. H., & Kornmann, M. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.030 · Cited by 51
Chronic Pancreatitis and Pancreatic Cancer
Kong, X., Sun, T., Kong, F., Du, Y., & Li, Z. (2014) · Gastrointestinal Tumors · doi:10.1159/000365306 · Cited by 47
Serum Heat Shock Protein 27 Is Increased in Chronic Pancreatitis and Pancreatic Carcinoma
Liao, W., Wu, M., Wang, H., Tien, Y., & Lin, J. (2009) · Pancreas · doi:10.1097/mpa.0b013e318198281d · Cited by 47
Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers
Fukushige, S., & Horii, A. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.03.022 · Cited by 47
The inherited genetics of pancreatic cancer and prospects for secondary screening
Vitone, L. J., Greenhalf, W., McFaul, C., Ghaneh, P., & Neoptolemos, J. P. (2006) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.10.007 · Cited by 46
Epigenetic alterations in intraductal papillary mucinous neoplasms of the pancreas
Sato, N., & Goggins, M. (2006) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-005-1056-2 · Cited by 47
Self-citation
Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature
James, E. S., Waldron-Lynch, M., & Saif, M. W. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32832b511e · Cited by 46
The power of microRNAs as diagnostic and prognostic biomarkers in liquid biopsies
Quirico, L., & Orso, F. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2019.103 · Cited by 46
Ultra-Sensitive Automated Profiling of EpCAM Expression on Tumor-Derived Extracellular Vesicles
Amrollahi, P., Rodrigues, M., Lyon, C. J., Goel, A., Han, H., & Hu, Y. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01273 · Cited by 44
Evaluation of cell-free DNA as a biomarker for pancreatic malignancies
Sikora, K. O., Bedin, C., Vicentini, C., Malpeli, G., D’Angelo, E., Sperandio, N., Lawlor, R. T., Bassi, C., Tortora, G., Nitti, D., et al. (2014) · The International Journal of Biological Markers · doi:10.5301/jbm.5000088 · Cited by 42
Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier
Bhasin, M., Ndebele, K., Bucur, O., Yee, E. U., Otu, H. H., Plati, J., Bullock, A. J., Gu, X., Castan, E., Zhang, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8139 · Cited by 43
MicroRNAs in pancreatic ductal adenocarcinoma
Park, J. Y. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i7.817 · Cited by 41
Plant Lectins as Medical Tools against Digestive System Cancers
Estrada-Martínez, L. E., Moreno‐Celis, U., Cervantes-Jiménez, R., Ferriz‐Martínez, R. A., Blanco‐Labra, A., & García-Gasca, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071403 · Cited by 41
Molecular markers in pancreatic cancer diagnosis
Herreros‐Villanueva, M., Gironella, M., Castells, A., & Bujanda, L. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.12.025 · Cited by 41
Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development
Dutruel, C., Bergmann, F., Rooman, I., Zucknick, M., Weichenhan, D., Geiselhart, L., Kaffenberger, T. M., Rachakonda, P. S., Bauer, A. S., Giese, N., et al. (2013) · Oncogene · doi:10.1038/onc.2013.312 · Cited by 40
Cystic Neoplasms of the Pancreas: Differential Diagnosis and Radiology Correlation
Hu, F., Hu, Y., Wang, D., Ma, X., Yue, Y., Tang, W., Liu, W. C., Wu, P., Peng, W., & Tong, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.860740 · Cited by 38
Pancreatic cancer early detection: Expanding higher-risk group with clinical and metabolomics parameters
Urayama, S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i6.1707 · Cited by 36
Gemcitabine Chemotherapy Versus 5-fluorouracil-based Concurrent Chemoradiotherapy in Locally Advanced Unresectable Pancreatic Cancer
Park, J. K., Ryu, J. K., Lee, J. K., Yoon, W. J., Lee, S. H., Kim, Y., & Yoon, Y. B. (2006) · Pancreas · doi:10.1097/01.mpa.0000236725.26672.be · Cited by 34
Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer.
Šálek, C., Mináriková, P., Benešová, L., Nosek, V., Strnad, R., Zavoral, M., & Minárik, M. (2009) · PubMed · Cited by 33
Towards pancreatic cancer diagnosis using EIS biochips
Chiriacò, M. S., Primiceri, E., Monteduro, A. G., Bove, A., Leporatti, S., Capello, M., Borgogno, S. F., Rinaldi, R., Novelli, F., & Maruccio, G. (2012) · Lab on a Chip · doi:10.1039/c2lc41127j · Cited by 32
Evaluation of circulating ADH and MIC-1 as diagnostic markers in Egyptian patients with pancreatic cancer
Mohamed, A. A., Soliman, H. H., Ismail, M. S., Ziada, D. H., Farid, T. M., Aref, A., Aldaly, M., & Elmageed, Z. Y. A. (2014) · Pancreatology · doi:10.1016/j.pan.2014.10.008 · Cited by 31
Macrophage inhibitory cytokine-1 versus carbohydrate antigen 19–9 as a biomarker for diagnosis of pancreatic cancer
Yang, Y., Yan, S., Tian, H., & Bao, Y. (2018) · Medicine · doi:10.1097/md.0000000000009994 · Cited by 31
Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer
Baine, M. J., Menning, M., Smith, L. M., Mallya, K. B., Kaur, S., Rachagani, S., Chakraborty, S., Sasson, A. R., Brand, R. E., & Batra, S. K. (2012) · Cancer Biomarkers · doi:10.3233/cbm-2012-0260 · Cited by 30
Tolerance and efficacy of palliative radiotherapy for advanced pancreatic cancer: A retrospective analysis of single-institutional experiences
Wolny-Rokicka, E. I., Sutkowski, K., Grządziel, A., Kaniszewska-Dorsz, Ż., Tukiendorf, A., Lipiński, J., & Wydmański, J. (2016) · Molecular and Clinical Oncology · doi:10.3892/mco.2016.851 · Cited by 29
A multiplexed bead assay for profiling glycosylation patterns on serum protein biomarkers of pancreatic cancer
Li, C., Zolotarevsky, E., Thompson, I. M., Anderson, M. A., Simeone, D. M., Casper, J. M., Mullenix, M. C., & Lubman, D. M. (2011) · Electrophoresis · doi:10.1002/elps.201000693 · Cited by 28
Prognostic and diagnostic significance of galectins in pancreatic cancer: a systematic review and meta-analysis
Sun, Q., Zhang, Y., Liu, M., Zeng, Y., Yu, X., Xu, X., & Qin, Y. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1025-5 · Cited by 29
Stool testing for the early detection of pancreatic cancer: rationale and current evidence
Haug, U., Wente, M. N., Seiler, C. M., Jesnowski, R., & Brenner, H. (2008) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.8.6.753 · Cited by 28
Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer
Nagaraju, G. P., Wu, C. S.-Y., Merchant, N., Chen, Z., Lesinski, G. B., & El‐Rayes, B. F. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.05.021 · Cited by 28
Molecular and Genetic Bases of Pancreatic Cancer
Vaccaro, V., Gelibter, A. J., Bria, E., Iapicca, P., Cappello, P., Modugno, F. D., Pino, M. S., Nuzzo, C. M. A., Cognetti, F., Novelli, F., et al. (2012) · Current Drug Targets · doi:10.2174/138945012800564077 · Cited by 27
The molecular biology of pancreatic cancer.
Abramson, M. A., Jazag, A., van der Zee, J. A., & Whang, E. E. (2007) · PubMed Central · Cited by 27
Molecular and Clinical Markers of Pancreas Cancer
Buxbaum, J. L., & Eloubeidi, M. A. (2015) · PubMed · doi:10.6092/1590-8577/3395 · Cited by 26

Authors: Goggins, M.
Affiliations: Johns Hopkins University (US)
Corresponding author: Goggins, Michael
ORCID: Goggins, Michael
Venue: Journal of Clinical Oncology
Publisher: American Society of Clinical Oncology (ASCO)
Published: 2005-07-10
Volume: 23
Issue: 20
Pages: 4524-4531
ISSN: 0732-183X (ISSN-L)
1527-7755
DOI: 10.1200/jco.2005.19.711
OpenAlex: W2127793931
Cited by: 214
References: 116
Citations by year: 2026: 4 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 13
FWCI: 1.65
Type: journal article
Language: en
Open access: closed
Locations: Journal of Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: pancreatic cancer, early diagnosis, diagnostic biomarkers, pancreatic ductal adenocarcinoma, gene expression changes, DNA methylation, proteomics, precancerous lesions, high-risk patients
MeSH terms: Genetic Markers, Humans, Pancreatic Neoplasms, Biomarkers, Tumor, Carcinoma, Pancreatic Ductal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular Markers of Early Pancreatic Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks