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Cited by 451

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer

Tukenova, Markhaba, Guibout, Catherine, Oberlin, Odile, Doyon, Françoise, Mousannif, Abdeddahir, Haddy, Nadia, Guérin, Sylvie, Pacquement, Hélène, Aouba, Albertine, Hawkins, Mike, Winter, Dave, Bourhis, Jean, Lefkopoulos, Dimitri, Diallo, Ibrahima, de Vathaire, Florent·2010·Journal of Clinical Oncology
DOI 10.1200/jco.2008.20.2267
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Abstract

Purpose: The purpose of this study was to assess the role of treatment in long-term overall and cardiovascular mortality after childhood cancer. Patients and Methods: We studied 4,122 5-year survivors of a childhood cancer diagnosed before 1986 in France and the United Kingdom. Information on chemotherapy was collected, and the radiation dose delivered to the heart was estimated for 2,870 patients who had received radiotherapy. Results: After 86,453 person-years of follow-up (average, 27 years), 603 deaths had occurred. The overall standardized mortality ratio (SMR) was 8.3-fold higher (95% CI, 7.6-fold to 9.0-fold higher) in relation to the general populations in France and the United Kingdom. Thirty-two patients had died as a result of cardiovascular diseases (ie, 5.0-fold [95% CI, 3.3-fold to 6.7-fold] more than expected). The risk of dying as a result of cardiac diseases (n = 21) was significantly higher in individuals who had received a cumulative anthracycline dose greater than 360 mg/m 2 (relative risk [RR], 4.4; 95% CI, 1.3 to 15.3) and in individuals who received an average radiation dose that exceeded 5 Gy (RR, 12.5 and 25.1 for 5 to 14.9 Gy and > 15 Gy, respectively) to the heart. A linear relationship was found between the average dose of radiation to the heart and the risk of cardiac mortality (estimated excess RR at 1 Gy, 60%). Conclusion: This study is the first, to our knowledge, to establish a relationship between the radiation dose received by the heart during radiotherapy for a childhood cancer and long-term cardiac mortality. This study also confirms a significant excess risk of cardiac mortality associated with a high cumulative dose of anthracyclines.

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Metadata

Authors
Tukenova, M., Guibout, C., Oberlin, O., Doyon, F., Mousannif, A., Haddy, N., Guérin, S., Pacquement, H., Aouba, A., Hawkins, M., Winter, D., Bourhis, J., Lefkopoulos, D., Diallo, I., & de Vathaire, F.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2010-03-10
Volume
28
Issue
8
Pages
1308-1315
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2008.20.2267
OpenAlex
W2136546051
Cited by
451
References
33
FWCI
27.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer. https://app.cochat.ai/papers/10.1200/jco.2008.20.2267
The paper
Tukenova, M., Guibout, C., Oberlin, O., Doyon, F., Mousannif, A., Haddy, N., Guérin, S., Pacquement, H., Aouba, A., Hawkins, M., Winter, D., Bourhis, J., Lefkopoulos, D., Diallo, I., & de Vathaire, F. (2010). Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2008.20.2267

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.