Amphiregulin and Epiregulin mRNA Expression in Primary Tumors Predicts Outcome in Metastatic Colorectal Cancer Treated With Cetuximab

Jacobs, Bart; De Roock, Wendy; Piessevaux, Hubert; Van Oirbeek, Robin; Biesmans, Bart; De Schutter, Jef; Fieuws, Steffen; Vandesompele, Jo; Peeters, Marc; Van Laethem, Jean-Luc; Humblet, Yves; Pénault-Llorca, Frederique; De Hertogh, Gert; Laurent-Puig, Pierre; Van Cutsem, Eric; Tejpar, Sabine

doi:10.1200/jco.2008.21.3744

Amphiregulin and Epiregulin mRNA Expression in Primary Tumors Predicts Outcome in Metastatic Colorectal Cancer Treated With Cetuximab

Purpose To study the power of the epidermal growth factor receptor (EGFR) epiregulin (EREG) and amphiregulin (AREG) ligands' expression in primary tumors to predict the outcome in patients with chemorefractory metastatic colorectal cancer (cmCRC) treated with the combination of cetuximab and irin…