The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma
Open accessAbstract
Purpose: To determine whether the clinical and molecular biologic characteristics of the alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) subtypes have relevance independent of the presence or absence of the PAX/FOXO1 fusion gene. Patients and Methods: The fusion gene status of 210 histopathologically reviewed, clinically annotated rhabdomyosarcoma samples was determined by reverse transcriptase polymerase chain reaction. Kaplan-Meier analysis was used to assess event-free survival and overall survival in fusion gene–negative ARMS (ARMSn; n = 39), fusion gene–positive ARMS (ARMSp; n = 94), and ERMS (n = 77). A total of 101 RMS samples were also profiled for whole-genome expression, and 128 were profiled for genomic copy number imbalances. Profiling data were analyzed by supervised and unsupervised methods to compare features related to histopathology and fusion gene status. Results were also projected by meta-analysis techniques across three separate publically available data sets. Results: Overall and event-free survival, frequency of metastases, and distribution of site at initial presentation were not significantly different between ARMSn and ERMS. Consistent with this, analysis of gene expression signatures could not reproducibly distinguish ARMSn from ERMS whereas fusion gene–positive cases were distinct. ARMSn and ERMS frequently show whole-chromosome copy number changes, notably gain of chromosome 8 with associated high levels of expression of genes from this chromosome. Conclusion: The clinical behavior and molecular characteristics of alveolar cases without a fusion gene are indistinguishable from embryonal cases and significantly different from fusion-positive alveolar cases. This implies that fusion gene status irrespective of histology is a critical factor in risk stratification of RMS.
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Pathology and genetics of tumours of soft tissue and bone
Fletcher, C. D. �., Unni, K., & Mertens, F. (2002) · Lund University Publications (Lund University) · Cited by 4,294
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Self-citationGene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.
Khan, J. I., Simon, R., Bittner, M. L., Chen, Y., Leighton, S. B., Pohida, T. J., Smith, P. D., Jiang, Y. Y., Gooden, G. C., Trent, J. M., et al. (1998) · PubMed · Cited by 437
Preprocessing of oligonucleotide array data
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Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma
Janoueix-Lerosey, I., Schleiermacher, G., Michels, E., Mosseri, V., Ribeiro, A., Lequin, D., Vermeulen, J., Couturier, J., Peuchmaur, M., Valent, A., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.16.0630 · Cited by 349
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Shern, J. F., Chen, L., Chmielecki, J., Wei, J. S., Patidar, R., Rosenberg, M., Ambrogio, L., Auclair, D., Wang, J., Song, Y. K., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0639 · Cited by 756
Ducimetière, F., Lurkin, A., Ranchère-Vince, D., Decouvelaere, A.-V., Péoc'h, M., Istier, L., Chalabreysse, P., Muller, C., Alberti, L., Bringuier, P.-P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020294 · Cited by 554
Malempati, S., & Hawkins, D. S. (2012) · Pediatric Blood & Cancer · doi:10.1002/pbc.24118 · Cited by 422
Skapek, S. X., Anderson, J., Barr, F. G., Bridge, J. A., Gastier-Foster, J. M., Parham, D. M., Rudzinski, E. R., Triche, T., & Hawkins, D. S. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24532 · Cited by 278
Tremblay, A. M., Missiaglia, E., Galli, G. G., Hettmer, S., Urcia, R., Carrara, M., Judson, R. N., Thway, K., Nadal, G., Selfe, J. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.029 · Cited by 178
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Metadata
- Authors
- Williamson, D., Missiaglia, E., de Reyniès, A., Pierron, G., Thuille, B., Palenzuela, G., Thway, K., Orbach, D., Laé, M., Fréneaux, P., Pritchard-Jones, K., Oberlin, O., Shipley, J., & Delattre, O.
- Venue
- Journal of Clinical Oncology
- Published
- 2010-05-01
- Volume
- 28
- Issue
- 13
- Pages
- 2151-2158
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2119501563
- Cited by
- 502
- References
- 23
- FWCI
- 28.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Williamson, D., Missiaglia, E., de Reyniès, A., Pierron, G., Thuille, B., Palenzuela, G., Thway, K., Orbach, D., Laé, M., Fréneaux, P., Pritchard-Jones, K., Oberlin, O., Shipley, J., & Delattre, O. (2010). Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2009.26.3814
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