The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Response, Survival, and Long-Term Toxicity After Therapy With the Radiolabeled Somatostatin Analogue [90Y-DOTA]-TOC in Metastasized Neuroendocrine Cancers
Abstract
Purpose: To investigate response, survival, and safety profile of the somatostatin-based radiopeptide 90 yttrium-labeled tetraazacyclododecane-tetraacetic acid modified Tyr-octreotide ([90 Y-DOTA]-TOC) in neuroendocrine cancers. Patients and Methods: In a clinical phase II single-center open-label trial, patients with neuroendocrine cancers were treated with repeated cycles of [90 Y-DOTA]-TOC. Each cycle consisted of a single intravenous injection of 3.7GBq/m 2 body-surface [90 Y-DOTA]-TOC. Additional cycles were withheld in case of tumor progression and/or permanent toxicity. Results: Overall, 1,109 patients received 2,472 cycles of [90 Y-DOTA]-TOC (median, two; range, one to 10 cycles per patient). Of the 1,109 patients, 378 (34.1%) experienced morphologic response; 172 (15.5%), biochemical response; and 329 (29.7%), clinical response. During a median follow-up of 23 months, 491 patients (44.3%) died. Longer survival was correlated with each: morphologic (hazard ratio [HR], 0.46; 95% CI, 0.38 to 0.56; median survival, 44.7 v 18.3 months; P < .001), biochemical (HR, 0.75; 95% CI, 0.59 to 0.96; 35.3 v 25.7 months; P = .023), and clinical response (HR, 0.68; 95% CI, 0.56 to 0.82; 36.8 v 23.5 months; P < .001). Overall, 142 patients (12.8%) developed grade 3 to 4 transient hematologic toxicities, and 103 patients (9.2%) experienced grade 4 to 5 permanent renal toxicity. Multivariable regression revealed that tumoral uptake in the initial imaging study was predictive for overall survival (HR, 0.45; 95% CI, 0.29 to 0.69; P < .001), whereas the initial kidney uptake was predictive for severe renal toxicity (HR, 1.59; 95% CI, 1.17 to 2.17; P = .003). Conclusion: This study documents the long-term outcome of [90 Y-DOTA]-TOC treatment in a large cohort. Response to [90 Y-DOTA]-TOC is associated with longer survival. Somatostatin receptor imaging is predictive for both survival after [90 Y-DOTA]-TOC treatment and occurrence of renal toxicity.
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Phase 3 Trial of 177 Lu-Dotatate for Midgut Neuroendocrine Tumors
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Hicks, R. J., Kwekkeboom, D. J., Krenning, E., Bodei, L., Grozinsky-Glasberg, S., Arnold, R., Borbath, I., Cwikla, J., Toumpanakis, C., Kaltsas, G., et al. (2017) · Neuroendocrinology · doi:10.1159/000475526 · Cited by 336
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Baum, R. P., Kulkarni, H. R., Singh, A., Kaemmerer, D., Mueller, D., Prasad, V., Hommann, M., Robiller, F. C., Niepsch, K., Franz, H., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24524 · Cited by 141
Metadata
- Authors
- Imhof, A., Brunner, P., Marincek, N., Briel, M., Schindler, C., Rasch, H., Mäcke, H. R., Rochlitz, C., Müller-Brand, J., & Walter, M. A.
- Venue
- Journal of Clinical Oncology
- Published
- 2011-06-10
- Volume
- 29
- Issue
- 17
- Pages
- 2416-2423
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2009629472
- Cited by
- 641
- References
- 6
- FWCI
- 31.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Response, Survival, and Long-Term Toxicity After Therapy With the Radiolabeled Somatostatin Analogue [90Y-DOTA]-TOC in Metastasized Neuroendocrine Cancers. https://app.cochat.ai/papers/10.1200/jco.2010.33.7873
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- Imhof, A., Brunner, P., Marincek, N., Briel, M., Schindler, C., Rasch, H., Mäcke, H. R., Rochlitz, C., Müller-Brand, J., & Walter, M. A. (2011). Response, Survival, and Long-Term Toxicity After Therapy With the Radiolabeled Somatostatin Analogue [90Y-DOTA]-TOC in Metastasized Neuroendocrine Cancers. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2010.33.7873
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