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Meta-Analysis of Psychosocial Interventions to Reduce Pain in Patients With Cancer
Open accessAbstract
Purpose: Pain is one of the most common, burdensome, and feared symptoms experienced by patients with cancer. American Pain Society standards for pain management in cancer recommend both pharmacologic and psychosocial approaches. To obtain a current, stable, and comprehensive estimate of the effect of psychosocial interventions on pain—an important clinical topic—we conducted a meta-analysis of randomized controlled studies among adult patients with cancer published between 1966 and 2010. Methods: Three pairs of raters independently reviewed 1,681 abstracts, with a systematic process for reconciling disagreement, yielding 42 papers, of which 37 had sufficient data for meta-analysis. Studies were assessed for quality using a modified seven-item Physiotherapy Evidence Database (PEDro) coding scheme. Pain severity and interference were primary outcome measures. Results: Study participants (N = 4,199) were primarily women (66%) and white (72%). The weighted averaged effect size across studies for pain severity (38 comparisons) was 0.34 (95% CI, 0.23 to 0.46; P < .001), and the effect size for pain interference (four comparisons) was 0.40 (95% CI, 0.21 to 0.60; P < .001). Studies that monitored whether treatment was delivered as intended had larger effects than those that did not (P = .04). Conclusion: Psychosocial interventions had medium-size effects on both pain severity and interference. These robust findings support the systematic implementation of quality-controlled psychosocial interventions as part of a multimodal approach to the management of pain in patients with cancer.
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“Existing behavioral symptom management interventions for cancer survivors have been primarily developed and tested among older cancer survivors (aged > 40) [27–32].”
From Improving symptom management for survivors of young adult cancer: rationale and study protocol for a pilot randomized controlled trial (2024) · cites this paper as [31]
In the citing paper
“Cancer affects the quality of life from its starting stage of diagnosis, progression, adverse effects of its treatment and diagnostic procedures by affecting the physical, physiological and emotional problems of patients [48-56] .”
From Alternative Medicine: New Ways to Treat Diseases and Therapies (2021) · cites this paper as [55]
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Metadata
- Authors
- Sheinfeld Gorin, S., Krebs, P., Badr, H., Janke, E. A., Jim, H. S. L., Spring, B., Mohr, D. C., Berendsen, M. A., & Jacobsen, P. B.
- Affiliations
- Sherri Sheinfeld Gorin, Herbert Irving Comprehensive Cancer Center, Columbia University; Paul Krebs, New York University School of Medicine; Hoda Badr, Mount Sinai School of Medicine, New York, NY; Elizabeth Amy Janke, University of the Sciences, Philadelphia, PA; Heather S.L. Jim and Paul B. Jacobsen, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL; Bonnie Spring and Mark A. Berendsen, Northwestern University; and David C. Mohr, Northwestern University, Feinberg School of Medicine, Chicago,...
- University of the Sciences (US)
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2012-02-10
- Volume
- 30
- Issue
- 5
- Pages
- 539-547
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC6815997
- OpenAlex
- W2130414707
- Cited by
- 292
- References
- 65
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 26 · 2021: 30 · 2020: 23 · 2019: 24 · 2018: 28 · 2017: 24 · 2016: 16 · 2015: 18 · 2014: 19 · 2013: 13 · 2012: 8
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (RC1DK087126)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Keywords
- cancer pain, psychosocial interventions, pain intensity, pain interference, pain management, multimodal pain management, intervention fidelity, quality of evidence
- MeSH terms
- Adaptation, Psychological, Adult, Aged, Biofeedback, Psychology, Female, Humans, Hypnosis, Male, Middle Aged, Neoplasms, Pain, Pain Measurement, Patient Education as Topic, Relaxation Therapy, Severity of Illness Index, Social Support, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Treatment Outcome, Pain Management
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