The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04
Abstract
Purpose: To compare the local recurrence (LR) rate between short-course (SC) and long-course (LC) neoadjuvant radiotherapy for rectal cancer. Patients and Methods: Eligible patients had ultrasound- or magnetic resonance imaging–staged T3N0-2M0 rectal adenocarcinoma within 12 cm from anal verge. SC consisted of pelvic radiotherapy 5 × 5 Gy in 1 week, early surgery, and six courses of adjuvant chemotherapy. LC was 50.4 Gy, 1.8 Gy/fraction, in 5.5 weeks, with continuous infusional fluorouracil 225 mg/m 2 per day, surgery in 4 to 6 weeks, and four courses of chemotherapy. Results: Three hundred twenty-six patients were randomly assigned; 163 patients to SC and 163 to LC. Median potential follow-up time was 5.9 years (range, 3.0 to 7.8 years). Three-year LR rates (cumulative incidence) were 7.5% for SC and 4.4% for LC (difference, 3.1%; 95% CI, −2.1 to 8.3; P = .24). For distal tumors (< 5 cm), six of 48 SC patients and one of 31 LC patients experienced local recurrence (P = .21). Five-year distant recurrence rates were 27% for SC and 30% for LC (log-rank P = 0.92; hazard ratio [HR] for LC:SC, 1.04; 95% CI, 0.69 to 1.56). Overall survival rates at 5 years were 74% for SC and 70% for LC (log-rank P = 0.62; HR, 1.12; 95% CI, 0.76 to 1.67). Late toxicity rates were not substantially different (Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer G3-4: SC, 5.8%; LC, 8.2%; P = .53). Conclusion: Three-year LR rates between SC and LC were not statistically significantly different; the CI for the difference is consistent with either no clinically important difference or differences in favor of LC. LC may be more effective in reducing LR for distal tumors. No differences in rates of distant recurrence, relapse-free survival, overall survival, or late toxicity were detected.
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Cites
Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer
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Cited by
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Japanese Society for Cancer of the Colon and Rectum, Watanabe, T., Muro, K., Ajioka, Y., Hashiguchi, Y., Ito, Y., Saito, Y., Hamaguchi, T., Ishida, H., Ishiguro, M., et al. (2018) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1101-6 · Cited by 2,467
Hashiguchi, Y., Muro, K., Saito, Y., Ito, Y., Ajioka, Y., Hamaguchi, T., Hasegawa, K., Hotta, K., Ishida, H., Ishiguro, M., et al. (2020) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01485-z · Cited by 1,922
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The multidisciplinary management of rectal cancer
Keller, D. S., Berho, M., Perez, R. O., Wexner, S. D., & Chand, M. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0275-y · Cited by 359
Metadata
- Authors
- Ngan, S. Y., Burmeister, B., Fisher, R. J., Solomon, M., Goldstein, D., Joseph, D., Ackland, S. P., Schache, D., McClure, B., McLachlan, S.-A., McKendrick, J., Leong, T., Hartopeanu, C., Zalcberg, J., & Mackay, J.
- Venue
- Journal of Clinical Oncology
- Published
- 2012-11-01
- Volume
- 30
- Issue
- 31
- Pages
- 3827-3833
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2138728054
- Cited by
- 921
- References
- 8
- FWCI
- 23.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04. https://app.cochat.ai/papers/10.1200/jco.2012.42.9597
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- Ngan, S. Y., Burmeister, B., Fisher, R. J., Solomon, M., Goldstein, D., Joseph, D., Ackland, S. P., Schache, D., McClure, B., McLachlan, S.-A., McKendrick, J., Leong, T., Hartopeanu, C., Zalcberg, J., & Mackay, J. (2012). Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2012.42.9597
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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