Effects of exercise on treatment-related adverse effects for patients with prostate cancer receiving androgen-deprivation therapy: a systematic review
Open accessAbstract
Purpose: Androgen-deprivation therapy is a commonly used treatment for men with prostate cancer; however, the adverse effects can be detrimental to patient health and quality of life. Exercise has been proposed as a strategy for ameliorating a range of these treatment-related adverse effects. We conducted a systematic review of the literature regarding the effects of exercise on treatment-related adverse effects in men receiving androgen-deprivation therapy for prostate cancer. Methods: An online electronic search of the Cochrane Library, EMBASE, MEDLINE, CINAHL, SPORTDiscus, and Health Source databases was performed to identify relevant peer-reviewed articles published between January 1980 and June 2013. Eligible study designs included randomized controlled trials as well as uncontrolled trials with pre- and postintervention data. Information was extracted regarding participant and exercise intervention characteristics as well as the effects of exercise on bone health, body composition, physical performance, cardiometabolic risk, fatigue, and quality of life. Results: Ten studies were included, with exercise interventions involving aerobic and/or resistance training. Exercise training demonstrated benefits in muscular strength, cardiorespiratory fitness, functional task performance, lean body mass, and fatigue, with inconsistent effects observed for adiposity. The impact of exercise on bone health, cardiometabolic risk markers, and quality of life are currently unclear. Conclusion: Among patients with prostate cancer treated with androgen-deprivation therapy, appropriately prescribed exercise is safe and may ameliorate a range of treatment-induced adverse effects. Ongoing research of high methodologic quality is required to consolidate and expand on current knowledge and to allow the development of specific evidence-based exercise prescription recommendations.
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Men on ADT may not build lean mass in response to resistance training, but several trials report small statistically significant improvements in lean body mass after 12-36 weeks.
“men on ADT may not be able to build lean mass in response to resistance training; however, several trials that have employed resistance training, or combined with aerobic training, have reported small, but statistically significant improvements in lean body mass after 12–36 weeks of training(96)”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [96]
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References 71 · Cited by 243
- Authors
- Gardner, J. R., Livingston, P. M., & Fraser, S. F.
- Affiliations
- Deakin University (AU)
- Venue
- Journal of Clinical Oncology
- Published
- 2014-02-01
- Volume
- 32
- Issue
- 4
- Pages
- 335-346
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2163135056
- Cited by
- 243
- References
- 71
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 13 · 2022: 23 · 2021: 19 · 2020: 20 · 2019: 20 · 2018: 29 · 2017: 29 · 2016: 24 · 2015: 29 · 2014: 18 · 2013: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- prostate cancer, androgen deprivation therapy, physical activity, treatment side effects, fatigue, bone health, body composition, lean body mass, cardiometabolic risk, quality of life, aerobic exercise, resistance training, exercise prescription
- MeSH terms
- Aged, Androgen Antagonists, Body Composition, Cardiovascular Diseases, Clinical Trials as Topic, Exercise Therapy, Fatigue, Humans, Male, Middle Aged, Physical Fitness, Prostatic Neoplasms, Psychomotor Performance, Quality of Life, Exercise, Bone Density, Treatment Outcome, Exercise Tolerance, Antineoplastic Agents, Hormonal, Metabolic Syndrome, Muscle Strength, Resistance Training
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