Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia

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Health Problems in Down Syndrome

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Methotrexate-Induced Neurotoxicity: An Uncommon Stroke Mimic

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Panda eye sign on diffusion weighted-MRI for the diagnosis of methotrexate-induced subacute leukoencephalopathy

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High-Dose Aminophylline for Methotrexate-Induced Neurotoxicity in a Patient With Brain Metastasis

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Emergent Radiotherapy for Leukemia-Induced Cranial Neuropathies Refractory to Intrathecal Therapy

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Chemotherapy-induced autoimmune-mediated encephalitis during germinoma treatment

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Methotrexate-induced toxic leukoencephalopathy: an uncommon stroke mimic

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Intrathecal chemotherapy neurotoxicity: unveiling the challenges of diagnosis, management, and prevention

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Interleukin-6–Mediated Inflammation May Cause Methotrexate-Induced Leukoencephalopathy

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Methotrexate-induced disruption of the serum-glucocorticoid inducible protein kinase 3 signaling pathway and its effects on brain development

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Metabolite Levels Measured Using Magnetic Resonance Spectroscopy in Pediatric Methotrexate‐Induced Leukoencephalopathy

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Leukoencephalopathy, a Frequent Complication After High‐Dose Methotrexate in Treatment of Osteosarcoma

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Case Report: Methrotexate Induced Neurotoxicity Mimicking Stroke, Following Leukoencephalopathy

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Autoimmune Ataxia During Maintenance Therapy for Acute Lymphoblastic Leukemia

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Successful therapeutic rechallenge after a severe episode of high dose methotrexate‑induced choreoathetosis: A case report

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Neurological Complications of Chemotherapy

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Imaging Findings in Children Presenting with CNS Nelarabine Toxicity

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Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance

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Acute Toxicity and Late Effects Related to Acute Lymphoblastic Leukemia Treatment

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Intrathecal treatment of Anti-N-Methyl-D-Aspartate receptor encephalitis: a promising approach for refractory cases

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The cognitive survivorship model: Bridging neuro-oncology and neurology

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A Stroke Mimic

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ALL relapse with multiple cranial nerve palsies and toxic leukoencephalopathy: treatment failure with treatment toxicity

Paul, B. S., Kaur, J., Singh, G., & Singh, G. (2018) · BMJ Case Reports · doi:10.1136/bcr-2018-224987 · Cited by 1

Clinical and electrophysiological characteristics of methotrexate encephalopathy in paediatric practice

Korshunova, E. A., Zakharova, A. Y., Тихомирова, Е. А., Khomyakova, S. P., Merishavyan, O. B., Masikhina, S. N., & Serkova, I. V. (2019) · Pediatric Hematology/Oncology and Immunopathology · doi:10.24287/1726-1708-2019-18-1-22-33 · Cited by 1

CNS relapse of childhood ALL: More than meets the eye

Roy, P. S., Banerjee, A., Tripathi, M., Suthar, R., & Trehan, A. (2021) · Pediatric Hematology Oncology Journal · doi:10.1016/j.phoj.2021.03.003 · Cited by 1

Encefalopatía subaguda reversible por metotrexato: notificación de un caso pediátrico

Marin, F., Astorquizaga, L., Font, D., Palmieri, F. I., & Cheistwer, A. (2021) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2021.e550 · Cited by 1

Neurologic complications in the treatment of childhood malignancies

Liou, A., Kline, C., & Mueller, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821976-8.00005-0 · Cited by 1

Methotrexate leukoencephalopathy

Thorat, J., Majumdar, S., & Goli, V. B. (2019) · Cancer Research Statistics and Treatment · doi:10.4103/crst.crst_73_19 · Cited by 1

Neurologic complications of oncologic therapy

Budhu, J. A., Wen, P. Y., & Lee, E. Q. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822835-7.00013-5 · Cited by 1

Acute and Long-term Neurological Complications of Acute Lymphoblastic Leukemia (ALL) Therapy in Latino Children

Brown, A. L., Raghubar, K. P., Scheurer, M. E., & Lupo, P. J. (2022) · Springer eBooks · doi:10.1007/978-3-031-14436-3_4 · Cited by 1

Clinical case of methotrexate overdose, the peculiarity of diagnostics in the conditions of the COVID-19 pandemic

Zaborskikh, I. V., Симоненко, В. Б., Сарманаев, С. Х., Tuktarova, R. R., & Yurina, Y. O. (2023) · Clinical Medicine (Russian Journal) · doi:10.30629/0023-2149-2023-101-4-5-241-246 · Cited by 1

Methotrexate-Induced Mucositis in a Patient With Angioimmunoblastic T-cell Lymphoma

Valenti, M. (2024) · Cutis · doi:10.12788/cutis.0956 · Cited by 1

Methotrexate for the neurologist

Jesuthasan, A., Baheerathan, A., Auger, S. D., Dorsey, R., Coker, R. K., Selvapatt, N., & Viegas, S. (2024) · Practical Neurology · doi:10.1136/pn-2024-004156 · Cited by 1

Drug‐Induced Cauda Equina Syndrome in an 8‐Year‐Old Boy With Acute Lymphoblastic Leukemia: An Uncommon Case Report

Babaee, M., Javadzadeh, M., & Hazeghi, A. (2025) · Clinical Case Reports · doi:10.1002/ccr3.70122 · Cited by 1

Methotrexate-induced neurotoxicity: Diagnostic challenges and the role of neurophysiological testing

D'hoore, P., & Terryn, J. (2025) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2025.06.004 · Cited by 1

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report

Makos, O. L., Shonka, N., Marth, K., Stricker, S. L., Keiper, M. D., & Schissel, M. E. (2025) · Journal of Medical Case Reports · doi:10.1186/s13256-025-05500-y · Cited by 1

[Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia].

Zou, D., Zeng, H., Yu, J. Z., Mai, H., Yuan, X., Wang, L., Liao, J.-X., & Wen, F. (2016) · PubMed Central · doi:10.7499/j.issn.1008-8830.2016.03.013 · Cited by 1

Neurological Complications of Chemotherapy

Carulli, A., King, M. K., & Estfan, B. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-67241-2.00007-0 · Cited by 1

Acute myelopathy during chemotherapy for childhood acute lymphoblastic leukemia

Matsumoto, K., Takeuchi, T., Sakaguchi, H., Yoshida, N., & Hama, A. (2021) · Pediatrics International · doi:10.1111/ped.14500 · Cited by 1

Clinical Reasoning: A 59-Year-Old Woman Presenting With Diplopia, Dysarthria, Right-Sided Weakness, and Encephalopathy

Manzano, G. S., Torre, M., Luskin, M. R., & Vaitkevicius, H. (2021) · Neurology · doi:10.1212/wnl.0000000000012151 · Cited by 1

Metotreksat kaynaklı beyin hasarına karşı bromelainin potansiyel faydalı etkilerinin araştırılması

Kaya, K., Gürel, A., & İPEK, V. (2021) · Pamukkale Medical Journal · doi:10.31362/patd.912469 · Cited by 1

Déficience intellectuelle et cancer chez l’enfant : analyse des pratiques concernant le choix du traitement

Dangles, M.-T., Davous, D., Vialle, G., Auvrignon, A., Angellier, É., & Bourdeaut, F. (2021) · Bulletin du Cancer · doi:10.1016/j.bulcan.2021.02.013 · Cited by 1

Methotrexate-Induced Septicemia With Severe Pancytopenia and Diffuse Cutaneous Ulcerative Lesions

Tiewsoh, I., Dey, B., Chhangte, M. Z., Lyngdoh, M., & Sathees, V. (2021) · Cureus · doi:10.7759/cureus.18069 · Cited by 1

Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia

Mateos, M. K., Marshall, G. M., Barbaro, P., Quinn, M. C. J., George, C., Mayoh, C., Sutton, R., Révész, T., Giles, J. E., Barbaric, D., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.268565 · Cited by 69

Clinico-radiological profile, management and follow-up of methotrexate induced neurotoxicity in children with acute lymphoblastic leukemia

Dhariwal, N., Moulik, N. R., Smriti, V., Dhamne, C. A., Chichra, A., Srinivasan, S., Narula, G., & Banavali, S. D. (2023) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2023.2245093 · Cited by 9

Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia.

Shuper, A., Stark, B., Kornreich, L., Cohen, I. J., Avrahami, G., & Yaniv, I. (2002) · PubMed · Cited by 66

Evaluation of Methotrexate Pharmacogenomic Variants to Predict Acute Neurotoxicity in Children with Acute Lymphoblastic Leukemia

Brown, A. L., Harris, R., Taylor, O. A., Zobeck, M. C., Bernhardt, M. B., Gramatges, M. M., Chavana, A. N., Morrison, A. C., Ludwig, K. F., Klesse, L. J., et al. (2024) · Blood · doi:10.1182/blood-2024-200891 · Cited by 3

Older age, CNS leukaemic involvement and induction tumour lysis increases the risk of methotrexate ( MTX )‐induced neurotoxicity in childhood acute lymphoblastic leukaemia/lymphoma: Experience from a tertiary care centre in South India

Rupakumar, T., Sankar, A., Vijayasekharan, K., Prasanth, V. R., Sojamani, G. C., Rajeswari, B., Nair, M., Anandarajan, R., Dennis, D., & Thankamony, P. (2024) · British Journal of Haematology · doi:10.1111/bjh.19559 · Cited by 7