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Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement
Open accessAbstract
Purpose Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Patients and methods Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center or three related community hospice programs, 620 patients (42%) were recruited, which represented 170 families. Families were stratified by three levels of family dysfunction (low communicating, low involvement, and high conflict) and randomly assigned to one of three arms: standard care or 6 or 10 sessions of a manualized family intervention. Primary outcomes were the Complicated Grief Inventory-Abbreviated (CGI) and Beck Depression Inventory-II (BDI-II). Generalized estimating equations allowed for clustered data in an intention-to-treat analysis. Results On the CGI, a significant treatment effect (Wald χ(2) = 6.88; df = 2; P = .032) and treatment by family-type interaction was found (Wald χ(2) = 20.64; df = 4; P Conclusion Family-focused therapy delivered to high-risk families during palliative care and continued into bereavement reduced the severity of complicated grief and the development of prolonged grief disorder.
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Systemic family therapy has been reported to decrease the severity and development of prolonged grief disorder.
“This type of therapy has been reported to decrease the severity and development of prolonged grief disorder (Kissane et al., 2016).”
From Prolonged grief disorder treatment: An approach to COVID-19 grief (2023) · cites this paper as Kissane et al., 2016
Family therapy given to high-risk families during palliative care and continued through bereavement decreases the severity of complicated grief and the development of prolonged grief disorder.
“-Family therapy given to high-risk families during palliative care and continued through bereavement decreases the severity of complicated grief and the development of prolonged grief disorder (Kissane et al., 2016).”
From Prolonged grief disorder treatment: An approach to COVID-19 grief (2023) · cites this paper as Kissane et al., 2016
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Metadata
- Authors
- Kissane, D. W., Zaider, T. I., Li, Y., Hichenberg, S., Schuler, T., Lederberg, M., Lavelle, L., Loeb, R., & Del Gaudio, F.
- Affiliations
- Ackerman Institute for the Family (US)
- David W. Kissane, Talia I. Zaider, Yuelin Li, Shira Hichenberg, Tammy Schuler, Marguerite Lederberg, Rebecca Loeb, and Francesca Del Gaudio, Memorial Sloan Kettering Cancer Center; David W. Kissane, Talia I. Zaider, and Yuelin Li, Weill Medical College of Cornell University; Lisa Lavelle, Ackerman Institute for the Family, New York, NY; and David W. Kissane, Monash University, Victoria, Australia
- Corresponding author
- Kissane, David W.
- Venue
- Journal of Clinical Oncology
- Published
- 2016-06-01
- Volume
- 34
- Issue
- 16
- Pages
- 1921-1927
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC4966341
- OpenAlex
- W2341192963
- Cited by
- 89
- References
- 29
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 14 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 4
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA115329, P30CA008748)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Grief, Bereavement, and Mental Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Keywords
- family therapy, advanced cancer, bereavement, complicated grief, prolonged grief disorder, family dysfunction, palliative care, family communication, family conflict, depression
- MeSH terms
- Adult, Bereavement, Communication, Family Therapy, Female, Humans, Male, Middle Aged, Neoplasms
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