The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study
Abstract
Purpose: The MOSAIC (Multicenter International Study of Oxaliplatin/Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer) study has demonstrated 3-year disease-free survival (DFS) and 6-year overall survival (OS) benefit of adjuvant oxaliplatin in stage II to III resected colon cancer. This update presents 10-year OS and OS and DFS by mismatch repair (MMR) status and BRAF mutation. Methods: Survival actualization after 10-year follow-up was performed in 2,246 patients with resected stage II to III colon cancer. We assessed MMR status and BRAF mutation in 1,008 formalin-fixed paraffin-embedded specimens. Results: After a median follow-up of 9.5 years, 10-year OS rates in the bolus/infusional fluorouracil plus leucovorin (LV5FU2) and LV5FU2 plus oxaliplatin (FOLFOX4) arms were 67.1% versus 71.7% (hazard ratio [HR], 0.85; P = .043) in the whole population, 79.5% versus 78.4% for stage II (HR, 1.00; P = .980), and 59.0% versus 67.1% for stage III (HR, 0.80; P = .016) disease. Ninety-five patients (9.4%) had MMR-deficient (dMMR) tumors, and 94 (10.4%) had BRAF mutation. BRAF mutation was not prognostic for OS (P = .965), but dMMR was an independent prognostic factor (HR, 2.02; 95% CI, 1.15 to 3.55; P = .014). HRs for DFS and OS benefit in the FOLFOX4 arm were 0.48 (95% CI, 0.20 to 1.12) and 0.41 (95% CI, 0.16 to 1.07), respectively, in patients with stage II to III dMMR and 0.50 (95% CI, 0.25 to 1.00) and 0.66 (95% CI, 0.31 to 1.42), respectively, in those with BRAF mutation. Conclusion: The OS benefit of oxaliplatin-based adjuvant chemotherapy, increasing over time and with the disease severity, was confirmed at 10 years in patients with stage II to III colon cancer. These updated results support the use of FOLFOX in patients with stage III disease, including those with dMMR or BRAF mutation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Current clinical data dictate that a portion of CRC patients with tumors where deficient mismatch repair or high microsatellite instability (dMMR/MSI-H) is identified, can benefit from the use of ICIs.”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [14]
In the citing paper
“This group is estimated to be around 15% of all CRC patients and 5% of those with metastatic CRC (mCRC) [13,14].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [14]
Citations
Cites
Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer
André, T., Boni, C., Mounedji-Boudiaf, L., Navarro, M., Tabernero, J. M., Hickish, T., Topham, C., Zaninelli, M., Clingan, P. R., Bridgewater, J. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032709 · Cited by 3,694
Self-citationA note on quantifying follow-up in studies of failure time
SCHEMPER, M., & Smith, T. L. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(96)00075-x · Cited by 2,592
André, T., Boni, C., Navarro, M., Tabernero, J. M., Hickish, T., Topham, C., Bonetti, A. V., Clingan, P. R., Bridgewater, J. A., Rivera, F., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.6771 · Cited by 2,276
Self-citationRibic, C. M., Sargent, D. J., Moore, M. J., Thibodeau, S. N., French, A. J., Goldberg, R. M., Hamilton, S. R., Laurent-Puig, P., Gryfe, R., Shepherd, L. E., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022289 · Cited by 2,160
Sargent, D. J., Marsoni, S., Monges, G., Thibodeau, S. N., Labianca, R., Hamilton, S. R., French, A. J., Kabat, B., Foster, N. R., Torri, V., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.1825 · Cited by 1,623
Benson, A. B., Schrag, D., Somerfield, M. R., Cohen, A. M., Figueredo, A. T., Flynn, P. J., Krzyzanowska, M. K., Maroun, J. A., McAllister, P. K., Cutsem, E. V., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.063 · Cited by 1,438
Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Labianca, R., Nordlinger, B., Beretta, G. D., Mosconi, S., Mandalà, M., Cervantes, A. M. R., & Arnold, D. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt354 · Cited by 1,436
Roth, A. D., Tejpar, S., Delorenzi, M., Yan, P., Fiocca, R., Klingbiel, D., Dietrich, D., Biesmans, B., Bodoky, G., Barone, C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.3452 · Cited by 1,178
Van Cutsem, E., Cervantes, A., Nordlinger, B., & Arnold, D. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu260 · Cited by 1,167
Kuebler, J. P., Wieand, H. S., O’Connell, M. J., Smith, R. E., Colangelo, L. H., Yothers, G., Petrelli, N. J., Findlay, M. P. N., Seay, T. E., Atkins, J. N., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.2974 · Cited by 1,055
Cited by
Sorted by citations
Items 501–600 of 686
Predictors based on cuproptosis closely related to angiogenesis predict colorectal cancer recurrence
Li, H., Zhang, Y., Feng, Y., Hu, X., Bi, L., Zhu, H., & Wang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1322421 · Cited by 2
A Review on Emerging Techniques for Diagnosis of Colorectal Cancer
Ravichandran, S. N., Das, D., Dayananda, E. K., Dey, A., Banerjee, A., Sun-Zhang, A., Zhang, H., Sun, X., & Pathak, S. (2024) · Cancer Investigation · doi:10.1080/07357907.2024.2315443 · Cited by 2
Logeart, J., Samaille, T., Falcoz, A., Svrcek, M., Dubreuil, O., Vernerey, D., Cohen, R., Cervera, P., Valverde, A., Parc, Y. R., et al. (2024) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2024.05.005 · Cited by 2
Self-citationBektaş, A. B., Hakki, L., Khan, A., Widmar, M., Wei, I. H., Pappou, E. P., Smith, J. J., Nash, G. M., Paty, P. B., García‐Aguilar, J., et al. (2024) · JCO Clinical Cancer Informatics · doi:10.1200/cci.23.00233 · Cited by 2
Chemo- and Radiotherapy of Gastrointestinal Tumors during Pregnancy
Wirth, T. C., Saborowski, A. L., Kuehnle, E., Fischer, M., Bueltmann, E., von Kaisenberg, C., & Merten, R. (2024) · Visceral Medicine · doi:10.1159/000540428 · Cited by 2
Gastrointestinal Malignancy: Genetic Implications to Clinical Applications
Trembath, H. E., Yeh, J. J., & Lopez, N. (2024) · Cancer treatment and research · doi:10.1007/978-3-031-61238-1_15 · Cited by 3
Sugiura, K., Takebe, K., Aoyama, J., Oshima, G., Kikuchi, H., Okabayashi, K., Aiko, S., & Kitagawa, Y. (2024) · Surgery Today · doi:10.1007/s00595-024-02965-0 · Cited by 2
Franques, P., Moreau, P., Evrard, C., Chong‐Si‐Tsaon, A., Frouin, É., Auriault, M., Moulin, V., Junca, A., Godet, J., Lebeau, L., et al. (2025) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848251347375 · Cited by 2
Battaglin, F., O’Neil, B. H., Stintzing, S., Ou, F., Zemla, T., Niedzwiecki, D., Innocenti, F., Höchster, H. S., von Weikersthal, L. F., Decker, T. W., et al. (2025) · European Journal of Cancer · doi:10.1016/j.ejca.2025.115694 · Cited by 2
Rice, L., Ganeshan, B., Wan, S., Chen, S.-H., Lilburn, D. M. L., Rodriguez‐Justo, M., Taylor, S. A., Shortman, R. I., Endozo, R., Khan, S., et al. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07568-6 · Cited by 2
Kang, B. W., Baek, D. W., Chang, E., Kim, H. J., Park, S. Y., Park, J. S., Choi, G., Baek, J. H., & Kim, J. G. (2021) · Journal of Yeungnam Medical Science · doi:10.12701/yujm.2021.01571 · Cited by 2
Phenotype-Genotype Correlation in Colorectal Cancer: A Real-Life Study
Gomes, C. F., Sousa, A. C., Rolim, I., Henriques, A. R., Branco, F., Janeiro, A., Malveiro, S., Dário, A. R., Oliveira, M. H., Borralho, P., et al. (2021) · GE Portuguese Journal of Gastroenterology · doi:10.1159/000516009 · Cited by 2
Miyata, T., Tomita, Y., Sannomiya, Y., Nagayama, T., Kin, R., Nishiki, H., Hashimoto, A., Fujii, Y., Miura, S., Kaida, D., et al. (2022) · Cancer Diagnosis & Prognosis · doi:10.21873/cdp.10071 · Cited by 2
Vangala, D., & Nilius‐Eliliwi, V. (2023) · Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie · doi:10.1055/a-2012-4047 · Cited by 2
A novel outpatient regimen in management of fluoropyrimidine-induced cardiotoxicity
Kasi, A., Gaudel, P., Lekkala, M. R., Al-Rajabi, R. M. T., Saeed, A., Sun, W., & Porter, C. (2023) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552231161822 · Cited by 2
Endoplasmic Reticulum Stress and Emerging Therapeutic Targets in Cancer
Yeap, J. W., & Tan, M. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_271-1 · Cited by 2
Neoadjuvant chemotherapy for locally advanced colonic cancer is not ready to be the standard of care
Vimalachandran, D. (2023) · British journal of surgery · doi:10.1093/bjs/znad184 · Cited by 2
Value of Real-World Evidence for Treatment Selection: A Case Study in Colon Cancer
Shen, L., van Gestel, A. J., Prinsen, P., Vink, G. R., van Erning, F. N., Geleijnse, G., & Kaptein, M. C. (2024) · JCO Clinical Cancer Informatics · doi:10.1200/cci.23.00186 · Cited by 3
Shortening adjuvant chemotherapy in stage III colon cancer: are we ready for a change?
Roda, D., Ciardiello, F., & Cervantes, A. M. R. (2018) · ESMO Open · doi:10.1136/esmoopen-2018-000392 · Cited by 3
Adjuvant therapy for colorectal cancer in 2020: has anything changed this millennium?
Bridgewater, J. A. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.01.015 · Cited by 2
Perioperative Chemotherapy: Review of Randomized Trials and Recommended Approach
Pugh, S. A., & Primrose, J. N. (2022) · Springer eBooks · doi:10.1007/978-3-031-09323-4_22 · Cited by 1
Chemotherapeutic Protocols for the Treatment of Gastrointestinal Tract Cancer
Cavalcanti, I. D. L. (2022) · Springer eBooks · doi:10.1007/978-3-031-10839-6_5 · Cited by 1
Hsieh, C., Chan, Y., Wu, C., Yen, L.-Y., Chang, Y., & Wang, Y. (2023) · Japan Journal of Nursing Science · doi:10.1111/jjns.12531 · Cited by 1
Gładyś, A., Kozak, S., Owczarek, A. J., Cedrych, E., Niemir, Z. I., Łącki-Zynzeling, S., Chudek, A., Mrochen-Domin, I., Gisterek, I., & Chudek, J. T. (2025) · Current Oncology · doi:10.3390/curroncol32060351 · Cited by 1
Liersch, P. K., Dierks, S., Andag, R., Liersch, T., de Boer, C., Kreutzer, J., Hille, A., Sülberg, H., Leha, A., & Schanz, J. (2025) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-025-04787-4 · Cited by 2
Real-World Evidence on Adjuvant Chemotherapy After Resection of Left-Sided Obstructive Colon Cancer
Zamaray, B., de Groot, J. W. B., van Hooft, J. E., Kok, N. F. M., Siersema, P. D., Consten, E. C. J., Tanis, P. J., & van Westreenen, H. L. (2025) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2025.09.002 · Cited by 1
Aliyeva, T., Siddiqui, H., Natche, J., Al-Wraikat, Y. A., Hossain, F. M., & El-Amri, I. (2025) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2025.10.004 · Cited by 2
Xu, J., Zhen, C., Rahman, M. S. U., Chen, H., Ren, Z., Zebin, X., Jin, Y., Liang, R., & Xu, S. (2026) · RSC Advances · doi:10.1039/d5ra07276j · Cited by 1
Molecular analysis of tumor recurrence using established cancer stem cell-line and drug discovery
Nakano, K., Oki, E., Yamazaki, M., Suzuki, M., Kawai, S., Zaitsu, Y., Nishime, C., Ando, K., Nagae, G., Harimoto, N., et al. (2026) · International Journal of Clinical Oncology · doi:10.1007/s10147-025-02948-2 · Cited by 1
Dölvers, F., Wansch, K., Kuehn, A., Dragomir, M. P., Janik, T., Joosten, M., Hilfenhaus, G., Vecchione, L., Felsenstein, M., Ma, D., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-47856-1 · Cited by 1
KRAS and BRAF mutations modify adjuvant chemotherapy outcomes in early stage colorectal cancer
Wankhede, D., Urruchúa-Rodríguez, M. J., Edelmann, D., Kloor, M., Bläker, H., Brobeil, A., Roth, W., Brenner, H., & Hoffmeister, M. (2026) · npj Precision Oncology · doi:10.1038/s41698-026-01494-y · Cited by 1
Long-term Outcomes After Resection of Solitary Colorectal Liver Metastases
Liu, M., Seier, K., Gonen, M., Wei, A. C.-C., Drebin, J., Balachandran, V. P., Kingham, T. P., Soares, K., Jarnagin, W. R., & D’Angelica, M. (2026) · Annals of Surgical Oncology · doi:10.1245/s10434-026-19904-7 · Cited by 1
Blancard, L. R.-S., Pernot, S., Fonck, M., & Palmieri, L. (2026) · Therapeutic Advances in Drug Safety · doi:10.1177/20420986261467894 · Cited by 1
韩, 峥., Zhang, Y., Tian, Q., Zhu, H., Wang, H., & Li, C. (2026) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-026-01578-9 · Cited by 1
Loft, M., Ganeshanathan, V., Wong, R., Mendis, S. R., Croxford, M. A., Jones, I. T., Gard, G., McLachlan, S., Tie, J., Gately, L., et al. (2026) · International Journal of Cancer · doi:10.1002/ijc.70754 · Cited by 1
Optimal number of lymph nodes to be examined in stage II colon cancer
Fedyanin, M. Y., Tryakin, A. A., Bulanov, A., Гордеев, С. С., Kuzmichev, D. V., Mamedli, Z. Z., Козлов, Н. А., & Tyulandin, S. A. (2019) · Surgery and Oncology · doi:10.17650/2220-3478-2019-9-1-42-50 · Cited by 1
Ramaswamy, A., Kothari, R. K., Desouza, A. L., Gupta, T., Bairwa, S. K., Kapoor, A., Kumar, A., Ventrapati, P., Ramadwar, M. S., Mandavkar, S., et al. (2019) · South Asian Journal of Cancer · doi:10.4103/sajc.sajc_176_18 · Cited by 1
Endoplasmic Reticulum Stress and Autophagy in Cancer
Tan, M., Tan, H. K., & Muhammad, T. S. T. (2020) · Springer eBooks · doi:10.1007/978-3-030-30845-2_18 · Cited by 1
To, Y. H., Degeling, K., McCoy, M. J., Wong, R., Jones, I. T., Dunn, C., Hong, W., Loft, M., Gibbs, P., & Tie, J. (2022) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13885 · Cited by 1
Determinantes de supervivencia en una cohorte de pacientes costarricenses con cáncer colorrectal
Ramos-Esquivel, A., Garita, E., & Masís-Marroquín, A. (2022) · Acta Médica Costarricense · doi:10.51481/amc.v64i2.1183 · Cited by 1
Immunotherapy-induced colitis in metastatic colorectal cancer: a systematic review and meta-analysis
Saowapa, S., Polpichai, N., Siladech, P., Wannaphut, C., Tanariyakul, M., Wattanachayakul, P., Bernal, D. A. O., Pleitez, H. J. G., & Tijani, L. (2024) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2024.2342723 · Cited by 1
State of the art: Targeting microsatellite instability in gastrointestinal cancers
Mencel, J., Alves, A., Angelis, V., Gerlinger, M., & Starling, N. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104387 · Cited by 1
Pappas, L., Quintanilha, J. C. F., Huang, R. S. P., & Parikh, A. R. (2024) · The Oncologist · doi:10.1093/oncolo/oyae269 · Cited by 1
Integrative Naturopathic Treatment Model for Colorectal Cancer: A Retrospective Study
Izadi‐Najafabadi, S., McQuarrie, L., Denotter, S., Elderfield, M., & Parmar, G. (2025) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130251326572 · Cited by 2
Advances in adjuvant therapy of colon cancer
Kumar, S., Noel, M. S., & Khorana, A. A. (2016) · Seminars in Colon and Rectal Surgery · doi:10.1053/j.scrs.2016.04.019 · Cited by 1
Adjuvant Systemic Therapy in Stage II and III Colon Cancer
Şen, F., & Pilancı, K. N. (2016) · InTech eBooks · doi:10.5772/63208 · Cited by 1
Translational Research in Familial Colorectal Cancer Syndromes
Ford, M. M. (2018) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0037-1602236 · Cited by 1
Kim, C., Ahmed, S., Ahmed, S., Brunet, B., Chalchal, H. I., Deobald, R. G., Döll, C., Dupre, M. P., Gordon, V., Lee‐Ying, R. M., et al. (2018) · Current Oncology · doi:10.3747/co.25.4109 · Cited by 1
Hereditary Gastrointestinal Cancers
Thirumurthi, S., Vilar, E., & Lynch, P. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-18890-0_33 · Cited by 1
Максимовна, П. Е., Fedyanin, M. Y., Boyarskikh, U. A., Андреевич, К. А., Анатольевна, М. Е., Polyakov, A. N., Кудашкин, Н. Е., Викторович, П. Д., Khrapov, E. A., Oskorobin, I. P., et al. (2022) · Surgery and Oncology · doi:10.17650/2686-9594-2022-12-1-27-34 · Cited by 1
Copy‐number intratumor heterogeneity as high‐risk feature of stage II colon cancer†
van den Bosch, T., Miedema, D. M., & Vermeulen, L. (2022) · The Journal of Pathology · doi:10.1002/path.5919 · Cited by 1
Thinking Too Fast About Chemotherapy for Resectable Colorectal Cancer Liver Metastases?
Pereira, A. A. L., & Fernandes, G. D. S. (2022) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2022.04.003 · Cited by 1
Tie, J., Lo, S., Cohen, J. D., Wang, Y., Wong, R., Shapiro, J. D., Harris, S., Khattak, A., Burge, M., Vogelstein, B., et al. (2021) · medRxiv · doi:10.1101/2021.09.02.21262816 · Cited by 1
Neoadjuvant Therapy Options for Advanced Rectal Cancer
Zaborowski, A. M., Kelly, P., & Bird, B. (2021) · doi:10.1002/9781119518495.ch4 · Cited by 1
Davies, E. B. J., Meyer, J., Basiliya, K., Corbett, G., Bowden, D. J., Chan, D. K. H., O'Cathail, S. M., Krakowska, M., Jabbar, F., & Church, D. N. (2024) · Wiley eBooks · doi:10.1002/9781119756422.ch12 · Cited by 1
Teranishi, N., & Uetake, H. (2025) · Cancers · doi:10.3390/cancers17030518 · Cited by 1
Aliyeva, T., Siddiqui, H., Natche, J., Al-Wraikat, Y. A., El-Amri, I., & Hossain, F. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5364979 · Cited by 1
Kolonkarzinom: 10-Jahres-Daten für FOLFOX4
Berndt, C. (2016) · Im Focus Onkologie · doi:10.1007/s15015-016-2392-6
Stroma and vessel characteristics in cancer : impact on prognosis and response to treatment
Mezheyeuski, A. (2016) · Figshare
PROGNOSTIC BIOMARKERS OF GASTROINTESTINAL NEOPLASIA
Scherbak, S. G., Vologzhanin, D. A., Gladyshev, D. V., Glotov, O. S., Голота, А. С., Kamilova, Т. A., Lantukhov, D. V., Kovalenko, S. A., Лисовец, Д. Г., & Sarana, А. М. (2018) · Surgery and Oncology · doi:10.17650/2220-3478-2017-7-4-20-30
Adjuvant Therapy for Resected Renal Cell Carcinoma—Still Searching
Wood, L. A. (2018) · European Urology · doi:10.1016/j.eururo.2018.07.023
Cancer du côlon non métastatique : désescalade thérapeutique
Lapeyre-Prost, A., & Taı̈eb, J. (2018) · Côlon & Rectum · doi:10.3166/cer-2018-0025
Ishikawa, S., Sawayama, H., Matsuo, A., Uchino, R., Honda, S., Hirota, M., & Baba, H. (2018) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyy192
What Should We Do Better? Lessons from Negative Results of a Biomarker Validation Study
Battaglin, F., & Lenz, H. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy217
Geschlechtsspezifische Unterschiede beim Management des kolorektalen Karzinoms
Reinacher-Schick, A. C., Höffken, N., Flott-Rahmel, B., & Tannapfel, A. (2019) · Die Gastroenterologie · doi:10.1007/s11377-019-0324-7
Soveri, L. (2019) · Työväentutkimus Vuosikirja
“Real‐life” outcome of gastrointestinal tumor therapies: A single‐center comparative study
Buratti, T., Mair, M. J., Mühlberger, N., & Mitterer, M. (2019) · Cancer Reports · doi:10.1002/cnr2.1182
Landmark Trials in Selected Gastrointestinal Cancers
Yajnik, S. V. (2019) · Springer eBooks · doi:10.1007/978-3-030-14405-0_5
Duration of Adjuvant Chemotherapy in Colon Cancer: Current Standards and New Updates
Greally, M., & Ilson, D. H. (2019) · Current Colorectal Cancer Reports · doi:10.1007/s11888-019-00438-y
Improving Clinical Trial Design in Gastrointestinal Oncology
Atasoy, A., & Mauer, M. E. L. (2019) · Springer eBooks · doi:10.1007/978-3-030-18890-0_28
Prognostic Factors in Geriatric Patients with Metastatic Colon Cancer
Ina, K., Kabeya, M., Yuasa, S., Kato, Y., Kayukawa, S., Kataoka, T., & Furuta, R. (2019) · Journal of Cancer Therapy · doi:10.4236/jct.2019.1010065
Optionen der neoadjuvanten Therapie beim Rektumkarzinom
Busse, A. (2020) · Springer eBooks · doi:10.1007/978-3-662-58159-9_7
Adjuvante Therapie des kolorektalen Karzinoms
Kraeft, A., Reinacher-Schick, A. C., & Folprecht, G. (2020) · Die Gastroenterologie · doi:10.1007/s11377-020-00453-8
Akabane, S., Hinoi, T., Akagi, K., Yamamoto, H., Sada, H., Shimizu, Y., Shimizu, W., Sudo, T., Onoe, T., Ishiyama, K., et al. (2020) · BMC Medical Genetics · doi:10.1186/s12881-020-01079-x
Adjuvant Therapies in Colon Cancer
Prasanna, T., & Yip, D. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93874
TOSCA—a delicious Swedish almond cake, an Italian opera and an Italian trial with important new data
Glimelius, B. L. G. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.10.598
Systemıc Chemotherapy in Colorectal Cancer
Ünal, O. Ü., Keser, M., & Akagündüz, B. (2020) · Springer eBooks · doi:10.1007/978-3-030-57273-0_34
Adjuvant Therapy in Patients with Colorectal Cancer
Qvortrup, C., & Pfeiffer, P. (2020) · Springer eBooks · doi:10.1007/978-3-030-58846-5_19
(Neo)adjuvante Behandlung beim frühen Kolonkarzinom
Kraeft, A., Stein, A., Modest, D. P., Fichtner‐Feigl, S., Tannapfel, A., & Reinacher‐Schick, A. (2020) · Der Onkologe · doi:10.1007/s00761-020-00876-6
Recurrence risk factors in elderly patients with stage II colorectal cancer
Higuchi, A., Aoyama, T., Takahashi, Y., Akimoto, N., Tsuchiya, K., Kurihara, M., Atsumi, Y., Kazama, K., Kato, A., Kawabe, T., et al. (2021) · Annals of Cancer Research and Therapy · doi:10.4993/acrt.29.5
Chemotherapie und andere adjuvante Maßnahmen nach kurativer Intervention beim Kolonkarzinom
Nöpel‐Dünnebacke, S., & Reinacher‐Schick, A. (2021) · Springer eBooks · doi:10.1007/978-3-662-60453-3_30
Adjuvant Therapy for Colorectal Cancer
Boland, P. M., Gong, J., & Fakih, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-18890-0_7
Moharana, L., Dasappa, L., Babu, M., Lokesh, K. N., Rudresha, A. H., Rajeev, L. K., Saldanha, S., & Jacob, L. A. (2021) · Oncology Journal of India · doi:10.4103/oji.oji_4_21
Colorectal cancer—moving forward one step at a time
Body, A. L., Chouhan, H. S., & Segelov, E. (2021) · Digestive Medicine Research · doi:10.21037/dmr-21-42
Implications thérapeutiques des mutations B-RAF dans le cancer colo-rectal
Lebrun, H., Turpin, A., & Zerbib, P. (2021) · Journal de Chirurgie Viscérale · doi:10.1016/j.jchirv.2021.02.010
Alhumaid, M., Sait, S., Fallatah, E. I. Y., AlSayegh, N. Y. N., Farsi, A., Nassif, M. O., Farsi, N. J., Akeel, N. Y., Samkari, A., Shabkah, A. A., et al. (2021) · Cureus · doi:10.7759/cureus.18670
Shang, A., Zhao, Z., Wang, Z., Li, D., Guo, Y. L., Qi, R., Yang, Y., & Wang, M. (2021) · Research Square · doi:10.21203/rs.3.rs-1033588/v1
Shang, A., Zhao, Z., Wang, Z., Li, D., Guo, Y. L., Qi, R., Yang, Y., & Wang, M. (2021) · Research Square · doi:10.21203/rs.3.rs-1076440/v1
Atci, M. M., Akagündüz, B., Demir, M., Arikan, R., Ay, S., Özer, M., Ayhan, M., Çil, İ., Demir, N., Özyurt, N., et al. (2022) · Journal of Chemotherapy · doi:10.1080/1120009x.2022.2040770
Systemic treatment of localized colorectal cancer
Hans, D., Vandamme, T., Teuwen, L.-A. M. N., Laura, W., Prenen, H., ten Tije, Jan, A., & Marc, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824297-1.00017-8
Adjuvant chemotherapy for stage II colon cancer: Whom to treat?
Pruthi, D. S., Pandey, M., & Nagpal, P. (2021) · Journal of Current Oncology · doi:10.4103/jco.jco_20_21
Schwenk, W. (2022) · Elsevier eBooks · doi:10.1016/b978-3-437-24812-2.00015-9
Khorasani, S., Pooni, A., Hameed, U., Gryfe, R., Ashamalla, S., Quereshy, F. A., & Baxter, N. N. (2020) · Springer eBooks · doi:10.1007/978-3-030-48363-0_6
Nguyen, V. (2017) · The American Pharmacists Association eBooks · doi:10.21019/pharmacotherapyfirst.colon-cancer_overview
Ishikawa, T., & Uetake, H. (2018) · Springer eBooks · doi:10.1007/978-981-13-3050-6_8
Chen, R., Basu, S., Meyers, J. P., & Shi, Q. (2022) · Statistical Methods in Medical Research · doi:10.1177/09622802221102621
Weixler, B., & Zuber, M. (2021) · doi:10.47275/2332-4864-114
Use of Circulating Tumour DNA to Assess Minimal Residual Disease in Gastrointestinal Cancers
Mukherji, R., Alqahtani, A. J., Winters, H. D., & Weinberg, B. A. (2022) · touchREVIEWS in Oncology & Haematology · doi:10.17925/ohr.2022.18.1.26
Dülgar, Ö., Ay, S., & Yıldırım, A. N. T. (2022) · Turkish Journal of Clinics and Laboratory · doi:10.18663/tjcl.1158511
Metadata
- Authors
- André, T., de Gramont, A., Vernerey, D., Chibaudel, B., Bonnetain, F., Tijeras-Raballand, A., Scriva, A., Hickish, T., Tabernero, J., Van Laethem, J. L., Banzi, M., Maartense, E., Shmueli, E., Carlsson, G. U., Scheithauer, W., Papamichael, D., Möehler, M., Landolfi, S., Demetter, P., Colote, S., Tournigand, C., Louvet, C., Duval, A., Fléjou, J.-F., & de Gramont, A.
- Affiliations
- Inserm (FR)
- Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS...
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2015-12-10
- Volume
- 33
- Issue
- 35
- Pages
- 4176-4187
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1960485012
- Cited by
- 683
- References
- 32
- Citations by year
- 2026: 43 · 2025: 56 · 2024: 75 · 2023: 65 · 2022: 74 · 2021: 92 · 2020: 97 · 2019: 47 · 2018: 59 · 2017: 41 · 2016: 32
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- European Society for Medical Oncology
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colon cancer, adjuvant chemotherapy, oxaliplatin, FOLFOX4, 5-fluorouracil, leucovorin, BRAF mutation, mismatch repair deficiency, overall survival, disease-free survival, prognostic factors, stage II colon cancer, stage III colon cancer, mosaic studies, long-term follow-up, microsatellite instability, mismatch repair proteins
- MeSH terms
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Leucovorin, Colonic Neoplasms, Female, Fluorouracil, Follow-Up Studies, Humans, Infusions, Intravenous, Injections, Intravenous, Male, Middle Aged, Mutation, Neoplasm Staging, Organoplatinum Compounds, Prognosis, Valine, Odds Ratio, Treatment Outcome, Chemotherapy, Adjuvant, Disease-Free Survival, Glutamic Acid, Proto-Oncogene Proteins B-raf, Kaplan-Meier Estimate, DNA Mismatch Repair
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
