Quality of Life in Patients With Advanced Cancer: Differential Association With Performance Status and Systemic Inflammatory Response
Open accessAbstract
Purpose: Quality of life is a key component of cancer care; however, the factors that determine quality of life are not well understood. The aim of this study was to examine the relationship between quality of life parameters, performance status (PS), and the systemic inflammatory response in patients with advanced cancer. Methods: An international biobank of patients with advanced cancer was analyzed. Quality of life was assessed at a single time point by using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C-30 (EORTC QLQ-C30). PS was assessed by using the Eastern Cooperative Oncology Group (ECOG) classification. Systemic inflammation was assessed by using the modified Glasgow Prognostic Score (mGPS), which combines C-reactive protein and albumin. The relationship between quality of life parameters, ECOG PS, and the mGPS was examined. Results: Data were available for 2,520 patients, and the most common cancers were GI (585 patients [22.2%]) and pulmonary (443 patients [17.6%]). The median survival was 4.25 months (interquartile range, 1.36 to 12.9 months). Increasing mGPS (systemic inflammation) and deteriorating PS were associated with deterioration in quality-of-life parameters (P < .001). Increasing systemic inflammation was associated with deterioration in quality-of-life parameters independent of PS. Conclusion: Systemic inflammation was associated with quality-of-life parameters independent of PS in patients with advanced cancer. Further investigation of these relationships in longitudinal studies and investigations of possible effects of attenuating systemic inflammation are now warranted.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The systemic inflammatory response reflects tumor immune cytokine activity and decreased nutritional status, such as appetite loss or fatigue.
“Furthermore, the systemic inflammatory response reflects tumor immune cytokine activity and decreased nutritional status, such as appetite loss or fatigue(28,29).”
From Clinical impact of inflammatory and nutrition index based on metabolic tumor activity in non‑small cell lung cancer treated with immunotherapy. (2024) · cites this paper as [29]
The available study summary (section and page not supplied) says systemic inflammation was assessed using C-reactive protein and albumin and was associated with quality-of-life measures in patients with advanced cancer. It does not say that the inflammatory response reflects tumor immune cytokine activity or decreased nutritional status, appetite loss, or fatigue. Searches for cytokines, nutritional status, appetite, and fatigue found no passage addressing those parts of the claim. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 27 · Cited by 162
- Authors
- Laird, B. J. A., Fallon, M., Hjermstad, M. J., Tuck, S., Kaasa, S., Klepstad, P., & McMillan, D. C.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Laird, Barry J.A.
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2016-08-10
- Volume
- 34
- Issue
- 23
- Pages
- 2769-2775
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC5019748
- OpenAlex
- W2466228288
- Cited by
- 162
- References
- 27
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 12 · 2023: 19 · 2022: 20 · 2021: 17 · 2020: 20 · 2019: 14 · 2018: 16 · 2017: 16 · 2016: 3
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, other-oa)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- European Commission
- Norges Forskningsråd
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- quality of life, advanced cancer, performance status, systemic inflammation, modified Glasgow Prognostic Score, C-reactive protein, albumin, ECOG performance status, EORTC QLQ-C30, gastrointestinal cancer, lung cancer, biobanks
- MeSH terms
- Patient Reported Outcome Measures, Aged, Appetite, C-Reactive Protein, Constipation, Diarrhea, Dyspnea, Fatigue, Female, Humans, Male, Middle Aged, Nausea, Neoplasms, Pain, Quality of Life, Severity of Illness Index, Sleep, Systemic Inflammatory Response Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
