The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Longitudinal Trajectory and Characterization of Cancer-Related Cognitive Impairment in a Nationwide Cohort Study
Open accessAbstract
Purpose: Cancer-related cognitive impairment (CRCI) is an important clinical problem in patients with breast cancer receiving chemotherapy. Nationwide longitudinal studies are needed to understand the trajectory and severity of CRCI in specific cognitive domains. Patients and Methods: The overall objective of this nationwide, prospective, observational study conducted within the National Cancer Institute Community Clinical Oncology Research Program was to assess trajectories in specific cognitive domains in patients with breast cancer (stage I-IIIC) receiving chemotherapy, from pre- (A1) to postchemotherapy (A2) and from prechemotherapy to 6 months postchemotherapy (A3); controls were assessed at the same time-equivalent points. The primary aim assessed visual memory using the Cambridge Neuropsychological Test Automated Battery Delayed Match to Sample test by longitudinal mixed models including A1, A2, and A3 and adjusting for age, education, race, cognitive reserve score, and baseline anxiety and depressive symptoms. We also assessed trajectories of CRCI in other aspects of memory as well as in attention and executive function with computerized, paper-based, and telephone-based cognitive tests. Results: In total, 580 patients with breast cancer (mean age, 53.4 years) and 363 controls (mean age, 52.6 years) were assessed. On the Delayed Match to Sample test, the longitudinal mixed model results revealed a significant group-by-time effect ( P < .005); patients declined over time from prechemotherapy (A1) to 6 months postchemotherapy (A3; P = .005), but controls did not change ( P = .426). The group difference between patients and controls was also significant, revealing declines in patients but not controls ( P = .017). Several other models of computerized, standard, and telephone tests indicated significantly worse performance by patients compared with controls from pre- to postchemotherapy and from prechemotherapy to 6 months postchemotherapy. Conclusion: This nationwide study showed CRCI in patients with breast cancer affects multiple cognitive domains for at least 6 months postchemotherapy.
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Statistical Analysis with Missing Data
Little, R. J. A., & Rubin, D. B. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/9781119013563 · Cited by 8,473
Small sample inference for fixed effects from restricted maximum likelihood
Kenward, M. G., & Roger, J. H. (1997) · Biometrics · doi:10.2307/2533558 · Cited by 4,552 · cited 2×
“Estimation was performed using the restricted maximum likelihood method, and inferences were performed using the KenwardRoger procedure.(53) Marginal adjusted means were used to quantify the changes from A1 to A2 and A1 to A3 (in addition to means for each time) by group.”
MethodTun, P. A., & Lachman, M. E. (2006) · Age and Ageing · doi:10.1093/ageing/afl095 · Cited by 249
Robbins, T. W., Semple, J., Kumar, R., Truman, M. I., Shorter, J., Ferraro, A., Fox, B., McKay, G., & Matthews, K. (1997) · Psychopharmacology · doi:10.1007/s002130050430 · Cited by 138
Cited by
Garland, S. N., Tulk, J., Savard, J., Rash, J. A., Browne, S., Urquhart, R., Seal, M., Thoms, J., & Laing, K. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.23.02330 · Cited by 29
Metadata
- Authors
- Janelsins, M. C., Heckler, C. E., Peppone, L. J., Ahles, T. A., Mohile, S. G., Mustian, K. M., Palesh, O., O’Mara, A. M., Minasian, L. M., Williams, A. M., Magnuson, A., Geer, J., Dakhil, S. R., Hopkins, J. O., & Morrow, G. R.
- Venue
- Journal of Clinical Oncology
- Published
- 2018-11-10
- Volume
- 36
- Issue
- 32
- Pages
- 3231-3239
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2889808313
- Cited by
- 160
- References
- 4
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Janelsins, M. C., Heckler, C. E., Peppone, L. J., Ahles, T. A., Mohile, S. G., Mustian, K. M., Palesh, O., O’Mara, A. M., Minasian, L. M., Williams, A. M., Magnuson, A., Geer, J., Dakhil, S. R., Hopkins, J. O., & Morrow, G. R. (2018). Longitudinal Trajectory and Characterization of Cancer-Related Cognitive Impairment in a Nationwide Cohort Study. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2018.78.6624
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