Ready, Set, Go: Setting Off on the Mission to Target KRAS in Colorectal Cancer
Abstract
Understanding the landscape of KRAS mutations in #CRC is crucial with over 2.8M annual diagnoses worldwide. Explore promising therapies and ongoing challenges in this comprehensive review. #CancerResearch #KRAS #ColorectalCancer
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The KRAS G12D mutation is seen in 12% of metastatic CRC and is the most common KRAS mutation in CRC.
“The KRAS G12D mutation is seen in 12% of metastatic CRC and is the most common KRAS mutation in CRC [95].”
From RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches (2025) · cites this paper as [95]
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References 21 · Cited by 14
- Authors
- Pellatt, A. J., Bhamidipati, D., & Subbiah, V.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Sarah Cannon (US)
- Venue
- JCO Oncology Practice
- Published
- 2024-10
- Volume
- 20
- Issue
- 10
- Pages
- 1289-1292
- ISSN
- 2688-1527 (ISSN-L)
- 2688-1535
- OpenAlex
- W4396873038
- Semantic Scholar
- 5e26954203a041f3d682a1527eb030d9e9e132ec
- Cited by
- 14
- References
- 21
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 2
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JCO Oncology Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- KRAS mutation, colorectal cancer, KRAS-targeted therapy, KRAS inhibitors
- MeSH terms
- Humans, Mutation, Colorectal Neoplasms, Proto-Oncogene Proteins p21(ras), Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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